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Cited by 143 publications
(142 citation statements)
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“…Challenge studies indicated a significant reduction of the virulence of the ibeA mutant. Based on prevalence studies and virulence attenuation of a mutant, conclusions have been drawn for several of the virulence genes identified to date for APEC strains (Blanco et al, 1997;Delicato et al, 2003;Dozois et al, 1992Dozois et al, , 2000Parreira & Gyles, 2003). It is therefore reasonable to assume that ibeA, when present, plays a role in the pathogenicity of APEC strains.…”
Section: Discussionmentioning
confidence: 99%
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“…Challenge studies indicated a significant reduction of the virulence of the ibeA mutant. Based on prevalence studies and virulence attenuation of a mutant, conclusions have been drawn for several of the virulence genes identified to date for APEC strains (Blanco et al, 1997;Delicato et al, 2003;Dozois et al, 1992Dozois et al, , 2000Parreira & Gyles, 2003). It is therefore reasonable to assume that ibeA, when present, plays a role in the pathogenicity of APEC strains.…”
Section: Discussionmentioning
confidence: 99%
“…Another gene whose precise function remains to be elucidated is the iss gene (Binns et al, 1979); this gene is presumed to play a role in serum resistance but, if so, its role seems to be minor (Mellata et al, 2003a). Different associations of virulence genes have been detected and could reflect the existence of different pathotypes (Delicato et al, 2003). Indeed, not a single virulence gene is found in any of the APEC strains that is absent from all non-pathogenic strains.…”
Section: Introductionmentioning
confidence: 99%
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“…Although Escherichia coli are likely widespread in the normal gastrointestinal flora and production environment of poultry, it is thought that only specific E. coli strains are endowed with virulence factors, enabling them to cause disease [8]. The disease they cause, avian colibacillosis, is extraintestinal in nature, manifesting in various ways, including as air sacculitis, cellulitis, and septicemia [2].…”
Section: Introductionmentioning
confidence: 99%
“…Although several virulence traits have been associated with the E. coli causing disease in birds [2], an avian pathogenic E. coli (APEC) pathotype remains ill-defined [8].…”
Section: Introductionmentioning
confidence: 99%