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“…Several classes of viruses have been shown naturally to induce myocarditis as a major feature of the pathologic response in diverse groups of wild, domesticated, and laboratory animals. Encephalomyocarditis virus (EMCV) 25,26 and Coxsackievirus 27 have been reported in baboons; however, antibodies to these viruses were not verified in any of these baboons with NLM.…”
Section: Discussionmentioning
“…Acute myocardial inflammation in non‐human primates can be precipitated by a variety of toxic and infectious agents [6, 14]. Generally cardiac involvement is secondary to a systemic process and is not often of clinical significance.…”
Section: Discussionmentioning
“…When given i.p. to susceptible mice, there is wide variation in the type of pathogenesis caused by serolo- gially indistinguishable variants of EMCV [Craighead and McLane, 1968;Burch and Rayburn, 1977;Gainer, 1974;Yoon et al, 1980;Giron and Patterson 1982;Miller et al, 1987;Cerutis et al, 19891. The B variant of EMCV does not produce overt signs of infection in mouse strains susceptible to the pathogenic effects of other variants of EMCV and is found in highest concentration in the heart and pancreas, with relatively low concentrations in the spleen and brain [Cerutis et al, 1989;Gould et al, 19841.…”
Section: Discussionmentioning
“…In fatal cases, the myocardium is infiltrated by mononuclear inflamma tory cells [68 ,70] . In laboratory animals, the coxsackie B viruses are extensively studied, due to their importance in viral myocarditis in children [71]. The viruses replicate in myocytes, causing myofiber necrosis and inflammation [71].…”
Section: Pseudorabies In Dogsmentioning
“…(a) A direct consideration of this research may lead to the fact that elevated environmental chemical levels do in fact aggravate or they may alleviate viral infections. (b) It is known that cigarette smoking aggravates influenzal infection in man (1), and many chemicals have been shown to increase viral infections experimentally (2). (c) Insofar as lead poisoning and viral infection is concerned, possible synergism between lead poisoning and eastern encephalitis viral (EEV) infection was observed "naturally" in a dead calf in Florida wherein EEV was isolated from the brain, the calf had a viral type of encephalitis histologically, and 20 ppm lead was present in the kidney of the calf.…”
Section: Introductionmentioning