Viral Load in Breast Milk Correlates with Transmission of Human Cytomegalovirus to Preterm Neonates, but Lactoferrin Concentrations Do Not

Strate, B. W. A. van der; Harmsen, M.; Schäfer, Peter; Swart, P.J.; Jahn, Gerhard; Speer, Christian P.; Meijer, Dirk K. F.; Hamprecht, Klaus

doi:10.1128/cdli.8.4.818-821.2001

Cited by 45 publications

(26 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dynamics of viral reactivation is similar in every lactating mother, irrespective of whether she acts as viral transmitter or non-transmitter. However, the maximum viral load as well as viral genome copy numbers are significantly different between maternal transmitters and non-transmitters (Hamprecht et al, 2003b;Van der Strate et al, 2001). The initial increase in viral load in breast milk during the first 3 weeks postpartum differs also interindividually, but no difference between maternal transmitters and non-transmitters could be found.…”

Section: Unimodal Kinetics Of Hcmv Reactivationmentioning

confidence: 83%

Cytomegalovirus transmission to preterm infants during lactation

Hamprecht

Maschmann

Jahn

et al. 2008

Journal of Clinical Virology

154

114

View full text Add to dashboard Cite

Section: Unimodal Kinetics Of Hcmv Reactivationmentioning

confidence: 83%

Cytomegalovirus transmission to preterm infants during lactation

Hamprecht

Maschmann

Jahn

et al. 2008

Journal of Clinical Virology

154

114

View full text Add to dashboard Cite

“…In other studies, risk factors for transmission were early onset of CMV DNAlactia and virolactia, 8 prolonged viral excretion in breast milk, 14 and higher milk whey viral loads. 14,41 These may suggest that treating breast milk from CMV-seropositive mothers would be necessary only until the infant reaches a certain age or birth weight, after which the risk of symptomatic disease decreases. A better understanding of risk factors for CMV-SLS in VLBW and premature infants may help refining guidelines for feeding breast milk from CMV-seropositive mothers to these infants.…”

Section: Figurementioning

confidence: 99%

Breast Milk–Acquired Cytomegalovirus Infection and Disease in VLBW and Premature Infants

et al. 2013

View full text Add to dashboard Cite

BACKGROUND: Very low birth weight (VLBW) and premature infants are at risk for developing postnatal cytomegalovirus (CMV) disease, including CMV-related sepsis-like syndrome (CMV-SLS) for which in the United States are lacking. METHODS: We performed a systematic review and meta-analysis to estimate the pooled proportions (and 95% confidence intervals) of VLBW and premature infants born to CMV-seropositive women with breast milk–acquired CMV infection and CMV-SLS. We combined these proportions with population-based rates of CMV seropositivity, breast milk feeding, VLBW, and prematurity to estimate annual rates of breast milk–acquired CMV infection and CMV-SLS in the United States. RESULTS: In our meta-analysis, among 299 infants fed untreated breast milk, we estimated 19% (11%–32%) acquired CMV infection and 4% (2%–7%) developed CMV-SLS. Assuming these proportions, we estimated a rate of breast milk–acquired CMV infection among VLBW and premature infants in the United States of 6.5% (3.7%–10.9%) and 1.4% (0.7%–2.4%) of CMV-SLS, corresponding to 600 infants with CMV-SLS in 2008. Among 212 infants fed frozen breast milk, our meta-analysis proportions were 13% (7%–24%) for infection and 5% (2%–12%) for CMV-SLS, yielding slightly lower rates of breast milk–acquired CMV infection (4.4%; 2.4%–8.2%) but similar rates of CMV-SLS (1.7%; 0.7%–4.1%). CONCLUSIONS: Breast milk–acquired CMV infection presenting with CMV-SLS is relatively rare. Prospective studies to better define the burden of disease are needed to refine guidelines for feeding breast milk from CMV-seropositive mothers to VLBW and premature infants.

show abstract

“…As already noted, studies in term newborns revealed that HCMV transmission occurred in spite of the presence of maternally derived neutralising antibodies to HCMV, and that there were no differences noted amongst transmitters and nontransmitters with respect to age, race, duration of lactation, duration of HCMV excretion in milk, presence of HCMV-specific IgA antibody, or infectivity titres of virus in milk, as noted by viral culture [14]. However, a more recent examination of the correlation between viral load in breast milk (using quantitative PCR) and transmission to the neonate did reveal a correlation between HCMV viral load and infection of the infant [27]. Interestingly, this study did not identify a relationship between breast milk levels of lactoferrin, an endogenous antimicrobial constituent of breast milk, and prevention of HCMV transmission.…”

Section: Viral/host Factors Modulating Transmission Of Hcmv From Breamentioning

confidence: 67%

Acquisition of human cytomegalovirus infection in infants via breast milk: natural immunization or cause for concern?

Schleiss

2005

Reviews in Medical Virology

View full text Add to dashboard Cite

Since the recognition in the 1960s that human cytomegalovirus (HCMV) infections could be transmitted by breast milk, there has been relatively little attention paid to the potential medical consequences of such infections. Indeed, since HCMV infections acquired by healthy newborn infants appear to be largely asymptomatic in nature, there has been no real incentive to develop or implement strategies to prevent transmission by this route. However, recent studies have identified a significant risk for low-birth weight, premature infants for the development of HCMV disease following acquisition of infection via breast milk. Such infections may cause considerable short-term morbidity and, in some cases, severe, life-threatening illness. There is little consensus amongst neonatologists on the approach to prevention and management of such infections. This review summarises the epidemiology and natural history of HCMV infections acquired via breast milk, and outlines available strategies for prevention and management of such infections, as well as opportunities for future clinical research on this understudied topic.

show abstract

Viral Load in Breast Milk Correlates with Transmission of Human Cytomegalovirus to Preterm Neonates, but Lactoferrin Concentrations Do Not

Cited by 45 publications

References 23 publications

Cytomegalovirus transmission to preterm infants during lactation

Cytomegalovirus transmission to preterm infants during lactation

Breast Milk–Acquired Cytomegalovirus Infection and Disease in VLBW and Premature Infants

Acquisition of human cytomegalovirus infection in infants via breast milk: natural immunization or cause for concern?

Contact Info

Product

Resources

About