VioBio lab adaptive optics: technology and applications by women vision scientists

Abstract

Purpose Adaptive Optics allows measurement and manipulation of the optical aberrations of the eye. We review two Adaptive Optics set‐ups implemented at the Visual Optics and Biophotonics Laboratory, and present examples of their use in better understanding of the role of optical aberrations on visual perception, in normal and treated eyes. Recent findings Two systems (AOI and AOII) are described that measure ocular aberrations with a Hartmann‐Shack wavefront sensor, which operates in closed‐loop with an electromagnetic deformable mirror, and visual stimuli are projected in a visual display for psychophysical measurements. AOI operates in infrared radiation (IR) light. AOII is provided with a supercontiniuum laser source (IR and visible wavelengths), additional elements for simulation (spatial light modulator, temporal multiplexing with optotunable lenses, phase plates, cuvette for intraocular lenses‐IOLs), and a double‐pass retinal camera. We review several studies undertaken with these AO systems, including the evaluation of the visual benefits of AO correction, vision with simulated multifocal IOLs (MIOLs), optical aberrations in pseudophakic eyes, chromatic aberrations and their visual impact, and neural adaptation to ocular aberrations. Summary Monochromatic and chromatic aberrations have been measured in normal and treated eyes. AO systems have allowed understanding the visual benefit of correcting aberrations in normal eyes and the adaptation of the visual system to the eye's native aberrations. Ocular corrections such as intraocular and contact lenses modify the wave aberrations. AO systems allow simulating vision with these corrections before they are implanted/fitted in the eye, or even before they are manufactured, revealing great potential for industry and the clinical practice. This review paper is part of a special issue of Ophthalmic & Physiological Optics on women in visual optics, and is co‐authored by all women scientists of the research team.

A Novel Intraocular Lens Simulator that Allows Patients to Experience the World Through Multifocal Intraocular Lenses Before Surgeries

“…Another method using a tunable lens for simulation, 26 – 33 the SimVis (2EYEVISION, Madrid, Spain), simulates a multifocal IOL using a tunable lens but does not insert a real IOL into the device. 26 , 28 , 29 , 31 The tunable lens changes its power periodically; for example, 0 D and +3.25 D. The subjects can see the world through the lens. At this time, the characteristics of specific multifocal IOLs were reflected by adjusting the power of the two diopters and the time proportion of the two diopters.…”

Matching convolved images to optically blurred images on the retina

“…A custom-developed polychromatic AO system at the Visual Optics and Biophotonics Lab (Institute of Optics, Spanish National Research Council, IO-CSIC, Madrid, Spain) was used in this study to correct the subject's aberrations and to induce aberrations in on-bench control experiments. The system and all its channels have been described in detail in previous publications ( Vinas et al, 2015 ; Marcos et al, 2017 ; Vinas, Aissati, et al, 2019 ; Vinas, Benedi-Garcia, et al, 2019 ; Aissati et al, 2020 ; Marcos et al, 2020 ; Vinas et al, 2020 ). The main channels used in this study of the system are as follows: The illumination channel, composed of a Supercontinuum Laser Source (SCLS, SC400 femtopower 1060 supercontinuum laser; Fianium Ltd, Southampton, United Kingdom, UK), in combination with an acusto-optic tunable filter (AOTF) module (FYLA LASER S.L, Valencia, Spain), which is controlled by radiofrequency drivers and selects the appropriate wavelength in visible light automatically (450–700 nm).…”

Adaptive optics visual simulators: a review of recent optical designs and applications [Invited]

“…The first Adaptive Optics Visual Simulator developed by Marcos et al was published in 2008 [ 7 ], and subsequent versions (VioBio polychromatic AO II) in 2015-2021 [ 19 – 24 ], revised in part in a recent review article [ 25 ]. An upgraded version has now started operation at the Marcos Lab in the Center for Visual Science at the University of Rochester [ 26 ].…”