Vincristine-Induced Unilateral Ptosis in a Child

Vincristine‐induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: Frequent autonomic and more severe cranial nerve involvement

“…On literature review, bilateral ptosis was the most common feature of VCR‐induced cranial neuropathy and unilateral ptosis has also been reported …”

“…On literature review, bilateral ptosis was the most common feature of VCR-induced cranial neuropathy 1,17,21 and unilateral ptosis has also been reported. 22,23 Vocal cord paralysis can be life threatening and requires active airway management. Several authors reported many cases of vocal cord paralysis, the youngest being 5-month-old.…”

Effectiveness of Pyridoxine and Pyridostigmine in the Treatment of Vincristine-Induced Bilateral Ptosis and External Ophthalmoplegia: A Case Report

“…There are three methods for treating vincristine-related neuropathy: reduction of vincristine dose; discontinuation of vincristine; and/or treatment with pyridoxine and pyridostigmine. Orhan et al 8 reported complete recovery from mild unilateral ptosis six weeks after discontinuation of vincristine. Batta et al 9 showed that reducing the dose of vincristine by one third resulted in the resolution of unilateral ptosis in 78 days.…”

Cranial Neuropathy, Induced by Vincristine Administration at a Child Suffering With Ewing,s Sarcoma

“…Нейропатия, связанная с поражением вегетативных сплетений, проявляется арефлексией детрузора мочевого пузыря, коликами и болями в животе, запором, ортостатической гипотен-зией [2,3,7]. КН встречается более редко и в большин-стве случаев считается тяжелым проявлением ВНК-нейротоксичности [1,3].…”

“…Механизм действия сводится к денатурации тубулина -белка в составе микротрубочек митотического веретена и ряда поверх-ностных антигенов лимфоцитов [1]. Наряду с проти-воопухолевым действием нейротоксичность -хорошо известный побочный эффект ВНК, впервые описан-ный в 1967 г.…”