Vincent's Angina

Williams, George A.

doi:10.1001/archderm.1929.01440030048006

Arch Derm Syphilol

1929

DOI: 10.1001/archderm.1929.01440030048006

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Vincent's Angina

George A. Williams¹

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1931

1943

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Cited by 6 publications

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“…Local applications of arsphenamine alone gave no relief, though the condition subsequently healed satisfactorily. Williams (1929) described the case of another woman who developed Vincent's angina for the first time while undergoing antisyphilitic treatment with intravenous neoarsphenamine. Local treatment with sodium biborate was followed by rapid clinical recovery and disappearance of organisms.…”

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Misuse of Intravenous N.A.B. for Vincent's Infection

Jewesbury¹

1943

BMJ

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confidence: 99%

Misuse of Intravenous N.A.B. for Vincent's Infection

Jewesbury¹

1943

BMJ

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Should Fusospirochetal Infections Be Treated With Arsenicals? Report of Cases

Smith¹

1933

Archives of Otolaryngology - Head and Neck Surgery

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In a recent article in The Journal of the American Medical Association, Lichtenberg, Werner and Lueck1 questioned both the pathogenicity of the fusospirochetal organisms and the success of treatment with the arsenicals. After a number of years of experience with the disease in the laboratory and in the clinic, I have arrived at the conclusion diametrically opposed to that of Lichtenberg and his associates, that this group of anaerobic organisms has under certain conditions a primary pathogenicity, and that arsenical therapy is usually the most efficient treatment. In view of this difference of opinion, it seems advisable to review the evidence in favor of the pathogenicity of this group of organisms and to report some cases which illustrate the indications, dangers and limitations of arsenical therapy in fusospirochetal infections.In 1894, Veillon2 observed in necrotic, foul lesions of the throat the following mixture of organisms: cocci, Leptotriches vibriones, Spirochaeta denticola and fusiform bacilli. In December of the same year, Plaut3 described Spirochaeta dentium and Miller's bacillus in pseudodiphtheritic angina. Following Vincent's4 observations in 1896 and 1899, this type of infection was accepted as a clinical entity. The gradual development of knowledge of the disease has been reviewed in a recent monograph.5

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The Pathogenicity of the Fusiform Bacillus and Spirillum of Plaut-Vincent

Lichtenberg¹,

Werner²,

Lueck³

1933

JAMA

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It has been quite generally accepted that the Pl aut\x=req-\ Vincent organisms have a pathogenic relationship to a variety of clinical entities. Unexceptionable proof of such relationship is wanting. The purpose of this report is to record clinical and experimental observations bearing on this subject. This study was undertaken at the suggestion of Dr. Joseph Brennemann.In the course of a study of a large series of diphtheria patients Plaut,1 in 1894, came on five cases of non\x=req-\ diphtheritic membranous angina, at first taken for diphtheria, in which fusiform bacilli and spirochetes were found. Plaut called these "Miller's organisms," since these had been described in 1883 by an American dentist, Willoughby D. Miller, who stated that pathogenic properties had already been ascribed to these organisms by Verneuil and Clado, who had found them in abscesses of the sublingual salivary gland, in submaxillary adenitis and in an abscess of a finger due to a human bite. Although the organisms were found beneath the gum margins in almost every mouth, and their numbers were greatly increased in gingivitis, Plaut believed them to be the causative agent in the anginas because the organisms were present in such great num¬ bers, in two instances in pure culture.In 1896, and more fully in 1899, Vincent2 described two diseases of the mucous membrane of the mouth and pharynx which he ascribed to the fusospirochetal organisms. The first was a mild stomatitis with super¬ ficial ulcérations, with a subfebrile course lasting two or three days. The ulcérations were covered with membranes, which came off easily but reformed to a less degree and gradually disappeared. In the second form a deep ulcer, which bled easily, lay beneath the membrane ; the fever was high, and a marked adenitis and a reddened edematous pharynx were present. The disease ran a protracted course, in one patient for two months. In the first form he found only the fusiform bacillus, while in the severer, ulceromembranous form From the Otho S. A. Sprague Memorial Institute Laboratory and the Children's Memorial Hospital. 1. Plaut, H. C.: Studien zur bacteriellen Diagnose der Diphtherie und den Anginen, Deutsche med. Wchnschr. 20: 920, 1894. 2. Vincent, M. H.: Recherches bact\l=e'\riologiquessur l'angine \l =a`\bacillus fusiformis, Ann. l'Inst. Pasteur 13: 609, 1899.the bacillus was associated with a spirillum in fifteen out of eighteen cases. Vincent was unable to reproduce the disease in the mouth or vagina of animals, and subcutaneous injections of the mixed organisms resulted in abscesses in which only pus organisms were found*. He was unable to cultivate the organisms and satisfac¬ torily attest their pathogenicity.Weaver and Tunnicliff3 in 1905 described the presence of the fusiform bacillus and spirillum in ulcerative stomatitis and succeeded in cultivating the bacillus anaerobically. These investigators were unable to produce any disease in rabbits with pure cultures. When mixed cultures were injected into the ears of rabbits, gangrene of the skin and deat...

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Vincent's Angina

Cited by 6 publications

References 0 publications

Misuse of Intravenous N.A.B. for Vincent's Infection

Misuse of Intravenous N.A.B. for Vincent's Infection

Should Fusospirochetal Infections Be Treated With Arsenicals? Report of Cases

The Pathogenicity of the Fusiform Bacillus and Spirillum of Plaut-Vincent

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