Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization

Liphardt, Anna‐Maria; Mündermann, Annegret; Koo, Seungbum; Bäcker, N.; Andriacchi, Thomas P.; Zange, Jochen; Mester, Joachim; Heer, Martina

doi:10.1016/j.joca.2009.07.007

Cited by 68 publications

(82 citation statements)

References 37 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, our results are in agreement with previous studies that reported a decrease in serum COMP concentration during rest, while in these studies the activity prior to the first blood sample was monitored (Andersson et al 2006;Mundermann et al 2005Mundermann et al , 2009. Second, the absolute COMP levels in our study are comparable to baseline levels in other studies after 15 min rest (Mundermann et al 2005) or unloading (Liphardt et al 2009). Third, the significant reduction in COMP levels persisted even over the following 7 h analysed in our study.…”

Section: Discussionsupporting

confidence: 92%

“…Both moderate walking (Mundermann et al 2005) and extensive running exercise (Kim et al 2009;Neidhart et al 2000) elevated the serum COMP concentration in healthy subjects. Moreover, in a bed rest study serum COMP concentration decreased after 24 h of immobilisation but returned to baseline levels after the subjects were mobile again (Liphardt et al 2009). The increase in serum COMP concentration was immediately after an exercise protocol and the return to the baseline level took 30 min after 30 min of walking (Andersson et al 2006;Mundermann et al 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans

et al. 2010

View full text Add to dashboard Cite

The purpose of the study was to investigate whether a relationship between the loading mode of physical activity and serum cartilage oligomeric matrix protein (COMP) concentration exists and whether the lymphatic system contributes to COMP release into the serum. Serum COMP levels were determined in healthy male subjects before, after and at 18 further time points within 7 h at four separate experimental days with four different loading interventions. The loading intervention included high impact running exercise, slow but deep knee bends, and lymphatic drainage of 30 min duration, respectively, and a resting protocol. The serum COMP levels were measured using a commercially available quantitative enzyme-linked immunosorbent assay. An increase (p < 0.001) in serum COMP concentration was detected immediately after 30 min running exercise. Slow but deep knee bends did not cause any significant changes in serum COMP levels. Lymphatic drainage also had no effect on the serum COMP concentration. After 30 min of complete rest the serum COMP level was significantly (p = 0.008) reduced. The elevation of COMP serum concentration seems to depend on the loading mode of the physical activity and to reflect the extrusion of COMP fragments from the impact loaded articular cartilage or synovial fluid.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Researchers have started to explore the possibility that WBV combined with exercise and physical therapies may offer benefits to patients with KOA, including muscle strength [8], balance control [9], and decreased self-perception of pain [9]. Additionally, previous studies found that mechanical stimulation not only increased matrix accumulation and decreased matrix metalloproteinase production in osteoarthritic chondrocytes [10], but also enhanced collagen and chondrogenic marker expression in normal cartilage [11]. …”

Section: Introductionmentioning

confidence: 99%

Effect of low-magnitude different-frequency whole-body vibration on subchondral trabecular bone microarchitecture, cartilage degradation, bone/cartilage turnover, and joint pain in rabbits with knee osteoarthritis

Wang

Liu

Chen³

et al. 2017

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroudWhole-body vibration(WBV) has been suggested for the prevention of subchondral bone loss of knee osteoarthritis (OA) . This study examined the effects of different frequency of whole-body vibration on subchondral trabecular bone microarchitecture, cartilage degradation and metabolism of the tibia and femoral condyle bone, and joint pain in an anterior cruciate ligament transection (ACLT)–induced knee osteoarthritisrabbit model.MethodNinety adult rabbits were divided into six groups: all groups received unilateral ACLT; Group 1, ACLT only; Group 2, 5 Hz WBV; Group 3, 10 Hz WBV; Group 4, 20 Hz WBV; Group 5, 30 Hz WBV; and Group 6, 40 Hz WBV. Pain was tested via weight-bearing asymmetry. Subchondral trabecular bone microarchitecture was examined using in vivo micro-computed tomography. Knee joint cartilage was evaluated by gross morphology, histology, and ECM gene expression level (aggrecan and type II collagen [CTX-II]). Serum bone-specific alkaline phosphatase, N-mid OC, cartilage oligometric protein, CPII, type I collagen, PIIANP, G1/G2 aggrecan levels, and urinary CTX-II were analyzed.ResultsAfter 8 weeks of low-magnitude WBV, the lower frequency (10 Hz and 20 Hz) WBV treatment decreased joint pain and cartilage resorption, accelerated cartilage formation, delayed cartilage degradation especially at the 20 Hz regimen. However, the higher frequencies (30 Hz and 40 Hz) had worse effects, with worse limb function and cartilage volume as well as higher histological scores and cartilage resorption. In contrast, both prevented loss of trabeculae and increased bone turnover. No significant change was observed in the 5 Hz WBV group.ConclusionOur data demonstrate that the lower frequencies (10 Hz and 20 Hz) of low-magnitude WBV increased bone turnover, delayed cartilage degeneration, and caused a significant functional change of the OA-affected limb in ACLT-induced OA rabbit model but did not reverse OA progression after 8 weeks of treatment.

show abstract

“…Three studies addressed the effects of immobilization and activity on biomarkers [9-11] and are remarkable for their novelty and rigor. The first, a crossover trial of 5 individuals, studied the effects of 14 days of enforced immobilization in a 6 degree “head-down-tilt-bed-rest’ position, with and without 2 brief treatments (5 minutes) of whole body vibration [9].…”

Section: Introductionmentioning

confidence: 99%

Osteoarthritis year 2010 in review: biochemical markers

Kraus

2011

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

At the 2010 OARSI congress in Brussels I was asked to present on “Biochemical Markers” in the “Year in Review” session. This provided an opportunity to summarize ongoing work and consensus building in the osteoarthritis research community related to osteoarthritis biomarkers, and second, and an opportunity to briefly overview a subset of studies from the previous 12 months related to soluble biomarkers that provided novel insights in the field. This review therefore briefly summarizes the progress in 2010 of the OARSI OA Biomarkers Global Initiative and the OARSI FDA Biomarkers Working Group, and provides a summary of selected osteoarthritis biomarker studies reported over the previous 12 months based on a review of articles from seven musculoskeletal journals and a PubMed search using the terms biomarkers and osteoarthritis.

show abstract

Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization

Cited by 68 publications

References 37 publications

Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans

Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans

Effect of low-magnitude different-frequency whole-body vibration on subchondral trabecular bone microarchitecture, cartilage degradation, bone/cartilage turnover, and joint pain in rabbits with knee osteoarthritis

Osteoarthritis year 2010 in review: biochemical markers

Contact Info

Product

Resources

About