Vestibular Disability/Handicap in Fibromyalgia: A Questionnaire Study

Mucci, Viviana; Demori, Ilaria; Rapallo, Fabio; Molinari, Elena; Losacco, Serena; Marinelli, Lucio; Browne, Cherylea J.; Burlando, Bruno

doi:10.3390/jcm11144017

Cited by 5 publications

(9 citation statements)

References 51 publications

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“…These pain conditions have been shown to affect disorders related to the vestibular aspect [46]. This further supports the need for the evaluation of the vestibular component in the pathophysiology of FMS [10].…”

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

“…The perception of chronic dizziness is one of the most reported complaints by patients with FMS, being manifested in about 64% of the cases [10]. Visually induced vertigo has been suggested to be one of the mechanisms responsible for the central dizziness disorder of FMS [10]. Instability or staggering, clumsiness while moving or carrying out activities of daily living, tinnitus, photosensitivity, "mental fog", migraine, as well as the vegetative courtship response such as nausea or stomach upset, are other complaints that are referred to frequently by those who have this disease [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Misperception of Visual Verticality Measured with a Virtual Reality Device in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study

Lomas-Vega,

Ogáyar-Anguita,

Segura-Sánchez

et al. 2023

Applied Sciences

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The objective of this study was to analyze the perception of visual verticality (VV) in subjects with Fibromyalgia Syndrome (FMS) and to correlate this with the symptoms of the disease and balance capacity. A cross-sectional study including 54 patients (51 female) was conducted. The evaluation of visual verticality was carried out with a virtual reality device by calculating the Mean Absolute Error (MAE) of degrees deviation in two tests: the Subjective Visual Vertical (SVV) test for the contribution of the vestibular system to the perception of verticality and the Rod and Frame test (RFT) for the contribution of the visual system. In total, 16 subjects (29.6%) presented good VV perception, 6 subjects (11.1%) presented an exclusive alteration of the SVV test, 19 subjects (35.2%) presented an exclusive alteration of the RFT and 13 subjects (24.1%) showed alteration in the two tests. The MAE in the SVV test showed medium correlations with several variables such as the Fibromyalgia Impact Questionnaire (FIQ) (Rho = 0.399, p = 0.003), the Pain Catastrophizing Scale (PCS) (Rho = 0.417, p = 0.002), the Dizziness Handicap Inventory (DHI) (Rho = 0.376, p = 0.005), and the Activities-Specific Balance Confidence Scale (ABC-16) (Rho = −0.367, p = 0.006). The MAE in the RFT showed medium correlations with the Instability Support Reduced (Rho = 0.327, p = 0.016) and Instability Gait Eyes Open (Rho = 0.312, p = 0.022) subscales of the JAEN (Joined Assessment of Equilibrium and Neuro-motor) Scale. Conclusions: Around 70% of the subjects with FMS showed some alteration in the perception of VV; 60% of these patients presented visual system dependence. The SVV test correlates with the impact and health status of FMS, and the RFT correlates with the alteration in the dynamic balance.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Misperception of Visual Verticality Measured with a Virtual Reality Device in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study

Lomas-Vega,

Ogáyar-Anguita,

Segura-Sánchez

et al. 2023

Applied Sciences

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“…Hearing and balance related symptoms were also identified by the SMP, whereas research in this area is also lacking. Preliminary data suggest a higher handicap relating to the presence of dizziness in patients with fibromyalgia compared to controls [49]. Furthermore, a recent, small-scale cross sectional study of the impact of tinnitus in fibromyalgia provides preliminary support for the link with central sensation as the severity of tinnitus was associated with severity of overall symptoms of fibromyalgia, and poorer quality of life [15].…”

Section: Discussionmentioning

confidence: 99%

Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Slater,

Schofield,

Wright

et al. 2023

Preprint

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BackgroundDeep phenotyping describes the use of formal and standardised terminologies to create comprehensive phenotypic descriptions of biomedical phenomena. While most often employed to describe patients, phenotype models may also be developed to characterise diseases. These characterisations facilitate secondary analysis, evidence synthesis, and practitioner awareness, thereby guiding patient care. The vast majority of this knowledge is derived from sources that describe an academic understanding of disease, including academic literature and experimental databases. Previous work has revealed a gulf between the priorities, perspectives, and perceptions held by healthcare researchers and providers and the users of clinical services. A comparison between canonical disease descriptions and phenotype models developed from public discussions of disease offers the prospect of discovery of new phenotypes, patient population stratification, and targeted mitigation of symptoms most damaging to patients quality of life.MethodsUsing a dataset representing disease and phenotype co-occurrence in social media text, we employ semantic techniques to identify phenotype associations for a set of common and rare diseases, constituting a phenotype model for those diseases that represents the public perspective. We create an integrated resource for biomedical database and literature-derived disease-phenotype associations by aligning data from several previous studies. We then explore differences between the disease-phenotype associations derived from writing in social media with those from the clinical literature and biomedical databases, with a focus on identification of differential themes and novel phenotypes. We also perform an evaluation of associations for several diseases, with specialist clinicians reviewing associations for validity, feasibility, and involvement in clinical care.FindingsWe identified 35,782 significant disease-phenotype associations from social media across 311 diseases, of which 304 could be linked to a combined resource of associations derived from academic sources. Social media-derived disease profiles recapitulated those from academic sources (AUC=0.874 (.95=0.858-0.891)). We further identified 26,081 novel phenotype associations that were not contained in the academic sources, of which 15,084 were considered significant. Constitutional symptoms, those holistic manifestations of disease affecting quality of life, were strongly over-represented in the social media phenotype, contributing more associations especially to endocrine, digestive, and reproductive diseases. An expert clinical review found that social media-derived associations were considered similarly well-established to those derived from literature, and were seen significantly more in patient clinical encounters.InterpretationThe phenotype model recovered from social media presents a significantly different perspective than existing resources derived from biomedical databases and literature, providing a large number of associations novel to the latter dataset. We propose that the integration and interrogation of these public perspectives on disease can inform clinical awareness, improve secondary analysis, and bridge understanding across healthcare stakeholders.

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“…Despite the prevalence of fibromyalgia ranging from 2% to 4% in epidemiological studies, accurate diagnosis remains challenging, potentially leading to the underestimation of its actual prevalence [ 2 ]. Fibromyalgia is often accompanied by comorbidities in various systems, including autoimmune diseases [ 3 , 4 ], psychiatric disorders [ 5 , 6 ], and central nervous system dysfunctions [ 7 , 8 ]. The issue of psychiatric comorbidity status in fibromyalgia has long been discussed since the onset of a psychiatric disorder could massively influence the patient quality of life, in turn worsening the prognosis of fibromyalgia [ 9 ].…”

mentioning

confidence: 99%

Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches

Gau

Hung

Chuang

et al. 2023

JCM

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Vestibular Disability/Handicap in Fibromyalgia: A Questionnaire Study

Cited by 5 publications

References 51 publications

Misperception of Visual Verticality Measured with a Virtual Reality Device in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study

Misperception of Visual Verticality Measured with a Virtual Reality Device in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study

Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches

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