2012
DOI: 10.1089/scd.2011.0311
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Abstract: Very small embryonic-like stem cells (VSELs) are possibly lost during cord blood banking and bone marrow (BM) processing for autologus stem cell therapy mainly because of their small size. The present study was conducted on human umbilical cord blood (UCB, n=6) and discarded red blood cells (RBC) fraction obtained after separation of mononuclear cells from human BM (n=6), to test this hypothesis. The results show that VSELs, which are pluripotent stem cells with maximum regenerative potential, settle along wit… Show more

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Cited by 105 publications
(100 citation statements)
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“…The Umbilical Cord Blood (UCB)-purified VSELs have also been reported to differentiate into neural cells [44] and after co-culture over OP-9 stroma cells were specified into HSCs similar to murine BM-derived VSELs [45]. Apart from umbilical cord blood and bone marrow, VSELs have also been reported in Wharton's jelly and gonadal tissue [46][47][48][49][50][51]. Their presence amongst the MSCs in the Wharton's jelly is in agreement with observations made by other groups that MSCs contain a sub-population of more primitive stem cells [52] or even as postulated by Taichman and group [53] that VSELs are precursors of MSCs.…”
Section: Developmental Origin Of Vselsmentioning
confidence: 99%
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“…The Umbilical Cord Blood (UCB)-purified VSELs have also been reported to differentiate into neural cells [44] and after co-culture over OP-9 stroma cells were specified into HSCs similar to murine BM-derived VSELs [45]. Apart from umbilical cord blood and bone marrow, VSELs have also been reported in Wharton's jelly and gonadal tissue [46][47][48][49][50][51]. Their presence amongst the MSCs in the Wharton's jelly is in agreement with observations made by other groups that MSCs contain a sub-population of more primitive stem cells [52] or even as postulated by Taichman and group [53] that VSELs are precursors of MSCs.…”
Section: Developmental Origin Of Vselsmentioning
confidence: 99%
“…We studied the VSELs in UCB and discarded fraction of BM [46]. Usually the 'buffy coat' obtained after Ficoll-Hypaque centrifugation is considered to be rich in stem cells and used for various studies over several decades.…”
Section: Our Studies On Vsels In Cord Blood and Bone Marrowmentioning
confidence: 99%
“…Stem cell therapy has emerged as a potential therapeutic option for cell deathrelated heart diseases [31,32]. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility, furthermore, the clinical efficacy of cell therapy remains to be proven [33].…”
Section: Introductionmentioning
confidence: 99%
“…Imaging allows for in vivo tracking of cells and can provide a better understanding in the evaluation of the functional effects of cell-based therapies [33,34]. Among these are direct labeling of cells with superparamagnetic agents, radionuclide, and the use of reporter genes for imaging of transplanted cells.…”
Section: Introductionmentioning
confidence: 99%
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