Very Mild Senile Dementia of the Alzheimer Type

Neuropsychological and Genetic Differences Between Age‐Associated Memory Impairment and Mild Cognitive Impairment Entities

“…These individuals perform poorly on memory tests and in other cognitive domains typically related to AD (e.g., language). These findings indicate that these subjects could be representing subclinical dementia or high‐dementia‐risk individuals, as previously reported in MCI studies 15,16,23–26 . Present data also reflect that the level of memory performance is related to the level of other cognitive functions, which are lower in the MCI group.…”

Neuropsychological and Genetic Differences Between Age‐Associated Memory Impairment and Mild Cognitive Impairment Entities

“…These individuals perform poorly on memory tests and in other cognitive domains typically related to AD (e.g., language). These findings indicate that these subjects could be representing subclinical dementia or high‐dementia‐risk individuals, as previously reported in MCI studies 15,16,23–26 . Present data also reflect that the level of memory performance is related to the level of other cognitive functions, which are lower in the MCI group.…”

Classification criteria for mild cognitive impairment

“…Within our cognitive complaint cohort followed over 3 years, the conversion rate to senile dementia (18% incidence over 3 years) is much higher than that observed in the general population. Our results are in agreement with previous clinical observations of subclinical cognitive deficit, [7][8][9][10]19 which report conversion rates of 15 to 53% over a similar time period. MCI criteria as currently defined have not, however, adequately captured this prodromal group in the general population.…”

Neuroleptics in the treatment of psychosis in late life: A rational approach

“…The presence of psychotic symptoms was associated with a significant increase in cortical degeneration and a relative preservation of the concentration of norepinephrine in both cortical and subcortical regions, but not with differences in the concen-trations of dopamine or its metabolites in any cortical or subcortical areas. This association between cortical degeneration and psychosis is consistent with several clinical reports that have associated psychosis among Alzheimer's disease patients with greater cognitive decline or severity of dementia (Cooper et al, 1990;Drevets and Rubin, 1989;Jeste et al, 1992;Lopez et al, 1991;Mayeux et al, 1985;Rosen and Zubenko, 1991;Rubin and Kinscherf, 1989;Stern et al, 1987). A similar excess in cognitive impairment and cortical changes on CT scan or MRI has been associated with functional psychoses both early (Rothschild et al, 1989) and late in life (Alexopoulos et al, 1988;Lesser et af., 1991;Miller et af., 1991;Rabins et al, 1984bRabins et al, , 1987.…”

Neuropsychological and Genetic Differences Between Age‐Associated Memory Impairment and Mild Cognitive Impairment Entities

“…These individuals perform poorly on memory tests and in other cognitive domains typically related to AD (e.g., language). These findings indicate that these subjects could be representing subclinical dementia or high‐dementia‐risk individuals, as previously reported in MCI studies 15,16,23–26 . Present data also reflect that the level of memory performance is related to the level of other cognitive functions, which are lower in the MCI group.…”

Classification criteria for mild cognitive impairment

“…Within our cognitive complaint cohort followed over 3 years, the conversion rate to senile dementia (18% incidence over 3 years) is much higher than that observed in the general population. Our results are in agreement with previous clinical observations of subclinical cognitive deficit, [7][8][9][10]19 which report conversion rates of 15 to 53% over a similar time period. MCI criteria as currently defined have not, however, adequately captured this prodromal group in the general population.…”

Neuroleptics in the treatment of psychosis in late life: A rational approach

“…The presence of psychotic symptoms was associated with a significant increase in cortical degeneration and a relative preservation of the concentration of norepinephrine in both cortical and subcortical regions, but not with differences in the concen-trations of dopamine or its metabolites in any cortical or subcortical areas. This association between cortical degeneration and psychosis is consistent with several clinical reports that have associated psychosis among Alzheimer's disease patients with greater cognitive decline or severity of dementia (Cooper et al, 1990;Drevets and Rubin, 1989;Jeste et al, 1992;Lopez et al, 1991;Mayeux et al, 1985;Rosen and Zubenko, 1991;Rubin and Kinscherf, 1989;Stern et al, 1987). A similar excess in cognitive impairment and cortical changes on CT scan or MRI has been associated with functional psychoses both early (Rothschild et al, 1989) and late in life (Alexopoulos et al, 1988;Lesser et af., 1991;Miller et af., 1991;Rabins et al, 1984bRabins et al, , 1987.…”

Neuropsychological and Genetic Differences Between Age‐Associated Memory Impairment and Mild Cognitive Impairment Entities

“…These individuals perform poorly on memory tests and in other cognitive domains typically related to AD (e.g., language). These findings indicate that these subjects could be representing subclinical dementia or high‐dementia‐risk individuals, as previously reported in MCI studies 15,16,23–26 . Present data also reflect that the level of memory performance is related to the level of other cognitive functions, which are lower in the MCI group.…”

Classification criteria for mild cognitive impairment

“…Within our cognitive complaint cohort followed over 3 years, the conversion rate to senile dementia (18% incidence over 3 years) is much higher than that observed in the general population. Our results are in agreement with previous clinical observations of subclinical cognitive deficit, [7][8][9][10]19 which report conversion rates of 15 to 53% over a similar time period. MCI criteria as currently defined have not, however, adequately captured this prodromal group in the general population.…”

Neuroleptics in the treatment of psychosis in late life: A rational approach

“…The presence of psychotic symptoms was associated with a significant increase in cortical degeneration and a relative preservation of the concentration of norepinephrine in both cortical and subcortical regions, but not with differences in the concen-trations of dopamine or its metabolites in any cortical or subcortical areas. This association between cortical degeneration and psychosis is consistent with several clinical reports that have associated psychosis among Alzheimer's disease patients with greater cognitive decline or severity of dementia (Cooper et al, 1990;Drevets and Rubin, 1989;Jeste et al, 1992;Lopez et al, 1991;Mayeux et al, 1985;Rosen and Zubenko, 1991;Rubin and Kinscherf, 1989;Stern et al, 1987). A similar excess in cognitive impairment and cortical changes on CT scan or MRI has been associated with functional psychoses both early (Rothschild et al, 1989) and late in life (Alexopoulos et al, 1988;Lesser et af., 1991;Miller et af., 1991;Rabins et al, 1984bRabins et al, , 1987.…”