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“…Although a small portion of patients experience long-term survival of more than 10 years, the 5-year overall survival rate is approximately 6% [5]. Thus, there is an urgent need to identify valuable biomarkers and promising therapeutic targets to improve the current diagnostic and treatment strategy for pancreatic cancer [6].…”
Section: Introductionmentioning
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“…Although a small portion of patients experience long-term survival of more than 10 years, the 5-year overall survival rate is approximately 6% [5]. Thus, there is an urgent need to identify valuable biomarkers and promising therapeutic targets to improve the current diagnostic and treatment strategy for pancreatic cancer [6].…”
Section: Introductionmentioning
“…One limitation in this study is the total sample size, which includes 23 STS samples and 13 VLTS samples. This problem is faced by other similar studies, especially in the context of VLTS samples, which are rare 5,10,13 . With this sample size constraint in mind, we sought to assess the robustness of our model through rigorous cross-validation and re-parameterization.…”
Section: Discussionmentioning
“…Further, several groups have identified a subset of very long time surviving (VLTS) patients, whose median survival is more than 10 years [5][6][7][8][9][10] .…”
Section: Introductionmentioning
“…Detailed individual-specific omics profiling may be required to provide novel insights into LT survival in pancreatic cancer disease 46 . DEGs alone are unlikely to fully characterize individual (LT) survival, as observed for other complex traits 22 .…”
Section: Discussionmentioning
“…Different transcription factors (GLI2 and GL3) were identified, linked to the KRAS mechanism of pancreatic tumorigenesis 58 . Identified Immunogenic gene (CDON) and regulatory gene (HDAC1) targets could play significant roles in the future immunotherapeutic strategies in long-term PDAC survivors 46 . CD8 revealed in our study is in line with recent studies in which CD8 expression profiling was linked to an immunologic subtype of PDAC with favorable survival 59 .…”
Section: Discussionmentioning