Vertical-Chamber Confinement of Juvenile-Age Rhesus Monkeys

Neural signaling mechanisms in depression: bridging classical monoamine hypotheses, animal models, and emerging antidepressant strategies

“…Building on this framework, McKinney and Harlow (1972) demonstrated that juvenile rhesus monkeys subjected to social isolation for 10 weeks exhibited increased clinging behavior—considered an index of anxiety—as well as reduced overall activity levels. These findings suggested that social isolation paradigms could be useful for modeling affective disturbances.…”

The Faster-Onset Antidepressant Effects of Hypidone Hydrochloride (YL-0919) in Monkeys Subjected to Chronic Unpredictable Stress

“…To record the behaviors of monkeys, two 5-min videos of each monkey were recorded at 9:30-11:30 AM and 1:00-3:00 PM. The present study employed four behavioral categories (see Table 2) defined by previous studies to assess the behaviors of monkeys (Harlow and Suomi, 1971;McKinney et al, 1972;Suomi and Harlow, 1972;Suomi et al, 1978). In the present study, huddling and self-clasping were categorized as negative behaviors, and locomotion and exploration were categorized as positive behaviors.…”

Animal Melancholy: Conceptualizing Depression in Psychiatric and Veterinary Contexts

“…В этом эксперименте к депрессивным макакам подсаживали особь, которую Харлов называл «обезьяна-психиатр» [Suomi, Harlow, McKinney 1972]. В качестве обезьян-психиатров выбирались макаки с нормальным социальным развитием, но моложе, чем животное с депрессией (им было примерно по три месяца).…”