Vertebral lesions associated with palmoplantar pustulosis

Abstract

Summary. Spinal lesions were reviewed in 9 pa

Syndromes with chronic non-bacterial osteomyelitis in the spine

“…In the literature the term is used mainly in older population. In some cases it is classified as a subtype of spondyloarthropathy due to sacroiliitis in some patients, as well as human leukocyte antigen B27 (HLA-B27) or human leukocyte antigen B8 (HLA-B8) were confirmed in limited cases [ 1 , 7 , 10 – 12 ]. Patients presenting SAPHO syndrome are usually adults in their 50-ties and 60-ties, or in some cases adolescents or children are included [ 1 , 2 , 7 , 13 ].…”

“…The histopathological examination of bone biopsy shows: specific granulation tissue with significant infiltration of, mostly lymphocytic, small round cells consistent with osteomyelitis, and plasmacytes, small round cell infiltrations, derangement of bony trabeculae and moderately increased osteoid, replacement of bone by fibrous tissue picture of chronic osteomyelitis with cellular infiltrate composed of lymphocytes and polymorphonuclear leucocytes, areas of microabscesses, no specific lesions or inflammatory cells, especially in the disk space [ 7 , 12 ]. In operative field spinal changes are fragile, resembling rheumatoid arthritis but including some sclerotic areas.…”

“…The spinal symptoms in SAPHO syndrome may be of great variety. The most common symptoms include low back pain and deep palpation tenderness, numbness and radial pain and sciatica, Lasègue's sign [ 2 , 7 , 12 ]. Sacroiliitis is observed in 13–52% of cases [ 7 ].…”

“…Spinal lesions in SAPHO syndrome are common with variable occurrence in different studies: 15.7%, 32% and 52% [ 7 , 9 , 43 ]. The mean age of the patients ranges from 47 to 51 years [ 12 , 42 ]. Observations of few cases of spinal manifestations showed the prevalence of females among patients: 66.6% and 92% [ 1 , 12 ].…”

“…The mean age of the patients ranges from 47 to 51 years [ 12 , 42 ]. Observations of few cases of spinal manifestations showed the prevalence of females among patients: 66.6% and 92% [ 1 , 12 ]. The interval between the initial symptoms and diagnosis is 6.4 years [ 1 ].…”