Vertebral Hemangiomas and Their Correlation With Other Pathologies

Slon, Viviane; Peled, Nir; Abbas, Janan; Stein, Dan J.; Cohen, Haim Y.; Hershkovitz, Israel

doi:10.1097/brs.0000000000001464

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…Localized trauma in humans has been associated with subsequent development of hemangiomas at various sites but is generally found to be subcutaneous or close to underlying bony structures. [24][25][26][27] Given the association between localized trauma and development of hemangiomas in humans, the same could be a potential concern in nonhuman primates. A positive correlation between increasing age and increasing neoplasia incidence in multiple species of primates including humans and macaques exists.…”

Section: Discussionmentioning

confidence: 99%

“…It is unusual that the hemangiomas in this animal occurred at this specific anatomic location. Localized trauma in humans has been associated with subsequent development of hemangiomas at various sites but is generally found to be subcutaneous or close to underlying bony structures . Given the association between localized trauma and development of hemangiomas in humans, the same could be a potential concern in nonhuman primates.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous pulmonary adenocarcinoma and subcutaneous cavernous hemangiomas arising in a squirrel monkey (Saimiri sciureus)

Salleng

Apple

et al. 2019

J of Medical Primatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spontaneous pulmonary adenocarcinoma and subcutaneous cavernous hemangiomas arising in a squirrel monkey (Saimiri sciureus)

Salleng

Apple

et al. 2019

J of Medical Primatology

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“…Assessment of reports of CCM is to some degree limited by the fact that, as radiologists and spinal clinicians are aware, intraosseous vascular malformations are common findings at routine CT and MRI of adults. An autopsy study [5] showed that intraosseous vascular malformations were present in 11% of bodies examined, and later CT and MRI studies of large numbers of adults showed the malformations present in approximately 26% of subjects [10,11]. Intraosseous vascular malformations are known to have an increasing prevalence with age [10].…”

mentioning

confidence: 99%

“…An autopsy study [5] showed that intraosseous vascular malformations were present in 11% of bodies examined, and later CT and MRI studies of large numbers of adults showed the malformations present in approximately 26% of subjects [10,11]. Intraosseous vascular malformations are known to have an increasing prevalence with age [10]. Most are clinically unimportant, although unusually large or fat-poor malformations are at greater risk of pathologic fracture [12][13][14].…”

mentioning

confidence: 99%

Vertebral Intraosseous Vascular Malformations in a Familial Cerebral Cavernous Malformation Population: Prevalence, Histologic Features, and Associations With CNS Disease

Tandberg

Bocklage

Bartlett

et al. 2020

American Journal of Roentgenology

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OBJECTIVE.-The purpose of this study was to investigate whether MRI-typical and MRIatypical intraosseous vascular malformations are associated with familial cerebral cavernous malformation (FCCM). MATERIALS AND METHODS.-In a retrospective matched case-control study, two radiologists reviewed the spinal imaging, both CT and MRI, of 22 patients with FCCM seen between 2006 and 2017 and of age-and sex-matched control subjects for MRI-typical and MRIatypical intraosseous vascular malformations. Quantitative analysis of lesions identified included vertebral level, size, and number of lesions. Pathologic samples from two lesions were analyzed for histologic and immunohistochemical features. Whether the presence of typical, atypical, and total intraosseous vascular malformations differed between patients and control subjects was tested. For patients with complete spinal imaging, whether intraosseous vascular malformations were associated with age, sex, brain lesion count, and spinal lesion count was also tested. RESULTS.-MRI-atypical intraosseous vertebral malformations were more commonly present in patients with FCCM (p = 0.003). Sixteen lesions were found in nine patients and none in the control group. The numbers of MRI-typical intraosseous vascular malformations were similar between patients and control subjects (p = 0.480). Age was associated with typical intraosseous vascular malformations (p = 0.027), though not with atypical malformations. MRI-atypical malformations were larger (mean diameter double) than MRI-typical malformations (p = 0.023). Histologic analysis of two lesions from different patients with pathologic collapse revealed the same histologic features consistent with combined capillary-venous malformations.

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“…Другие авторы [7], основываясь на результатах обследования 196 больных, пришли к выводу, что основной причиной развития ГП является нарушение микроциркуляции (с повреждением эндотелия микрососудов) внутри тела позвонка, приводящее в конечном итоге к гиперваскуляризации. ГП у наблюдаемых больных были связаны с поражениями дисков (р=0,004), травмами позвоночника в анамнезе (р=0,037), злокачественными новообразованиями (р=0,016), сахарным диабетом (р=0,023), сердечно-сосудистыми заболеваниями (р=0,003), но не с ожирением.…”

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Current view on vertebral hemangioma

Грушина¹,

Titov²

2020

Priorov J. of Traum. & Orthoped.

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An analytical review of publications devoted to various aspects of vertebral hemangioma was conducted from following electronic databases: Scopus, Web of Science, MedLine, The Cochrane Central Register of Controlled Trials, ScienceDirect, PubMed, and elibrary, CyberLeninka. The review contains actual data on the frequency of its occurrence, the possible causes of appearance and variants of development. The issues of diagnosis of vertebral hemangioma are considered in the historical context: clinical manifestations, objective modern sur- vey methods. Special attention is paid to the morphological and pathogenetic criteria for changes in the verte- bra. It is connected with the fact, that the diagnosis vertebra hemangioma prior to the morphological study is more a collective concept than a deﬁnitive diagnosis. It is noted that the modern concept of therapeutic tac- tics is based on the nature of course of vertebral hemangioma: aggressive and non-aggressive forms. The article presents the criteria for its aggressiveness according to domestic and foreign authors. The main methods of treating neoplasm are presented: radiation therapy, alcoholization, puncture embolization of tumor vessels, puncture vertebroplasty, stenthoplasty, open interventions. In the conclusion of the review, it is emphasized that if medical tactics in case of aggressive vertebral hemangiomas are actively developed by scientiﬁc researchers, today studies on suﬃcient clinical material with the long-term analysis of diﬀerentiated application of physio- therapeutic treatment of the patients with vertebral pain syndromes in combination with non-aggressive vertebral hemangioma do not exist.

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Vertebral Hemangiomas and Their Correlation With Other Pathologies

Abstract: 4.

Cited by 9 publications

References 44 publications

Spontaneous pulmonary adenocarcinoma and subcutaneous cavernous hemangiomas arising in a squirrel monkey (Saimiri sciureus)

Spontaneous pulmonary adenocarcinoma and subcutaneous cavernous hemangiomas arising in a squirrel monkey (Saimiri sciureus)

Vertebral Intraosseous Vascular Malformations in a Familial Cerebral Cavernous Malformation Population: Prevalence, Histologic Features, and Associations With CNS Disease

Current view on vertebral hemangioma

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