Vertebral bone destruction in sickle cell disease: infection, infarction or both

Abstract

Infectious and vaso-occlusive vertebral bone and joint destruction in two patients with sickle cell disease (SCD) are featured by H-shaped vertebrae, kyphotic angulation, osteolysis of endplates and collapse of intervertebral discs as shown by X-ray films and magnetic resonance imaging. Staphylococcal serology supported the diagnosis of staphylococcal osteomyelitis/spondylo-discitis in both SCD patients. The difficulties of establishing the causes and treatment of the osteoarthropathy in these particular cases are discussed in the light of the literature.

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

“…Nonetheless, the heterogenic clinical presentation is seldom limited to this population alone. The variation present in this study, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 consistent with overall spinal infection cases, urges additional research within other subsets to construct reliable diagnosis patterns. Because this is the first systematic review of PSI in a previously unexplored population, its purpose is to supplement the aforementioned goal of ultimately guiding clinical decision making for PSI patient populations.…”

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

“…Nonetheless, the heterogenic clinical presentation is seldom limited to this population alone. The variation present in this study, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 consistent with overall spinal infection cases, urges additional research within other subsets to construct reliable diagnosis patterns. Because this is the first systematic review of PSI in a previously unexplored population, its purpose is to supplement the aforementioned goal of ultimately guiding clinical decision making for PSI patient populations.…”

Salmonella Spondylodiscitis in a Patient with Sickle Cell Disease - Case Report and Literature Review

“…Chills, nausea and lower limbs pain are other less common clinical features. Vertebral infarction in SCD patients and osteomyelitis can present similarly with back pain, fever and raised inflammatory markers [5,21]. The current case presented typically with low back pain and fever proceeded by bactremia.…”

Osteomyelitis: A manifestation of sickle cell anemia

“…The most common casual organism is Salmonella (especially Salmonella enteritidis, Salmonella typhimurium, Salmonella paratyphi B, Salmonella choleraesuis and Salmonella aureus) followed by Staphylococcus aureus, which is seen in 10% of patients suffering from sickle cell-related osteomyelitis. Certain other causative bacterial species are Enterobacter spp., Haemophilus influenza, and Escherichia coli [1,21,22] (Table 1). Bacteremia caused due to the gram-negative microbes is believed to result from sickling within the mesenteric vessels and subsequent gastrointestinal infarction [23].…”

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

“…Nonetheless, the heterogenic clinical presentation is seldom limited to this population alone. The variation present in this study, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 consistent with overall spinal infection cases, urges additional research within other subsets to construct reliable diagnosis patterns. Because this is the first systematic review of PSI in a previously unexplored population, its purpose is to supplement the aforementioned goal of ultimately guiding clinical decision making for PSI patient populations.…”

Salmonella Spondylodiscitis in a Patient with Sickle Cell Disease - Case Report and Literature Review

“…Chills, nausea and lower limbs pain are other less common clinical features. Vertebral infarction in SCD patients and osteomyelitis can present similarly with back pain, fever and raised inflammatory markers [5,21]. The current case presented typically with low back pain and fever proceeded by bactremia.…”

Osteomyelitis: A manifestation of sickle cell anemia

“…The most common casual organism is Salmonella (especially Salmonella enteritidis, Salmonella typhimurium, Salmonella paratyphi B, Salmonella choleraesuis and Salmonella aureus) followed by Staphylococcus aureus, which is seen in 10% of patients suffering from sickle cell-related osteomyelitis. Certain other causative bacterial species are Enterobacter spp., Haemophilus influenza, and Escherichia coli [1,21,22] (Table 1). Bacteremia caused due to the gram-negative microbes is believed to result from sickling within the mesenteric vessels and subsequent gastrointestinal infarction [23].…”

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

“…Nonetheless, the heterogenic clinical presentation is seldom limited to this population alone. The variation present in this study, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 consistent with overall spinal infection cases, urges additional research within other subsets to construct reliable diagnosis patterns. Because this is the first systematic review of PSI in a previously unexplored population, its purpose is to supplement the aforementioned goal of ultimately guiding clinical decision making for PSI patient populations.…”

Salmonella Spondylodiscitis in a Patient with Sickle Cell Disease - Case Report and Literature Review

“…Chills, nausea and lower limbs pain are other less common clinical features. Vertebral infarction in SCD patients and osteomyelitis can present similarly with back pain, fever and raised inflammatory markers [5,21]. The current case presented typically with low back pain and fever proceeded by bactremia.…”

Osteomyelitis: A manifestation of sickle cell anemia

“…The most common casual organism is Salmonella (especially Salmonella enteritidis, Salmonella typhimurium, Salmonella paratyphi B, Salmonella choleraesuis and Salmonella aureus) followed by Staphylococcus aureus, which is seen in 10% of patients suffering from sickle cell-related osteomyelitis. Certain other causative bacterial species are Enterobacter spp., Haemophilus influenza, and Escherichia coli [1,21,22] (Table 1). Bacteremia caused due to the gram-negative microbes is believed to result from sickling within the mesenteric vessels and subsequent gastrointestinal infarction [23].…”