Versicoamides F–H, Prenylated Indole Alkaloids from <i>Aspergillus tennesseensis</i>

Liu, Li; Wang, Long; Li, Bao; Ren, Jinwei; Basnet, Buddha Bahadur; Liu, Ruixing; He, Liming; Han, Junjie; Yin, Wen‐Bing; Liu, Hongwei

doi:10.1021/acs.orglett.7b00145

Cited by 37 publications

(20 citation statements)

References 18 publications

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“…The cytotoxicities of compounds 1-19 were investigated with the Cell Counting Kit 8 (CCK8) cell viability assay [4,33]. K562, SW480, HEPG2 cells were purchased from National Infrastructure of Cell Line Resource.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

et al. 2019

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As part of our search for new cytotoxic and antimicrobial natural products from endolichenic fungi, 19 compounds including 1 new 10-member lactone (2), 1 new polyacetylene glycoside (3), 1 new brasilane-type sesquiterpenoid glycoside (4), and 2 isobenzofuran-1(3H)-one derivatives (5 and 6) were isolated from the solid culture of the endolichenic fungus Hypoxylon fuscum. Their structures were unambiguously elucidated by NMR spectroscopic data, MS, ECD (electronic circular dichroism) calculation, and chemical methods. The cytotoxic effects on K562, SW480, and HEPG2 cell lines and the antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were assessed. Compounds 1, 2, and 5 exhibited moderate cytotoxicity against K562, SW480, and HEPG2 cell lines while compounds 1, 9, and 11 displayed weak antibacterial activity against S. aureus.

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Section: Cytotoxicity Assaymentioning

confidence: 99%

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

et al. 2019

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“…Some species of this section produce kipukasins, nucleoside derivates, and the mycotoxin, sterigmatocystin [56][57][58]. A. tennesseensis has been reported to produce various compounds such as versicoamides F-H, prenylated indole alkaloids, diorcinol L, and (R)-diorcinol B [59,60]. In Korea, there are only six species reported to belong to the section Versicolores, including A. creber, A. jensenii, A. nidulans, A. sydowii, A. tabacinus, and A. versicolor.…”

Section: Discussionmentioning

confidence: 99%

Five New Records of the Family Aspergillaceae in Korea, Aspergillus europaeus, A. pragensis, A. tennesseensis, Penicillium fluviserpens, and P. scabrosum

et al. 2020

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During an investigation of the fungi from the Aspergillaceae family obtained from different environmental sources in Korea, we isolated six strains, including CNUFC WJC9-1, CNUFC BPM36-33, CNUFC MSW6, CNUFC ESW1, CNUFC TM6-2, and CNUFC WD17-1. The morphology and phylogeny of these isolates were analyzed based on their partial b-tubulin (BenA) and calmodulin (CaM) gene sequences. Based on the morphological characteristics and sequence analyses, the isolates CNUFC WJC9-1, CNUFC BPM36-33, CNUFC TM6-2, and CNUFC WD17-1 were identified as A. europaeus, A. pragensis, Penicillium fluviserpens, and P. scabrosum, respectively, and isolates CNUFC MSW6 and CNUFC ESW1 were identified as A. tennesseensis. To the best of our knowledge, the species A. europaeus, A. pragensis, A. tennesseensis, P. fluviserpens, and P. scabrosum have not been previously reported in Korea.

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“…The organic solvent was evaporated under reduced pressure to get a crude extract, which was then partitioned between MeOH and petroleum ether (PE). The MeOH fraction was evaporated to get the defatted extract (7.0 g), which was subjected to CC over ODS with a MeOH/H 2 Graphostromol G (7). Colorless oil.…”

Section: Extract and Isolationmentioning

confidence: 99%

“…Fungi are well‐known for their ability to produce a wide array of structurally diverse and biologically active secondary metabolites . In recent years, marine‐derived fungi have attracted considerable attention to natural product chemists and pharmacologist because many of their secondary metabolites are structurally novel and possess interesting biological and pharmacological properties .…”

Section: Introductionmentioning

confidence: 99%

Graphostromols A–K, Eleven New Chained Polyketides from the Deep‐Sea‐Derived Graphostroma sp

Niu

Xie

Xia

et al. 2019

Chemistry & Biodiversity

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Chromatographic separation of the AcOEt extract of the fermented cultures of the deep‐sea‐derived fungus Graphostroma sp. resulted in the isolation of 11 new chained polyketides, namely graphostromols A–K (1–11). The structures of the new compounds were established by the extensive analyses of their NMR and HR‐ESI‐MS data. The absolute configuration at C‐11 in 1 was determined on the basis of the modified Mosher's method. Compounds 1–5, bearing a 2,2,10,10‐tetramethyldodecane skeleton, were discovered for the first time from nature. All isolates were evaluated for their cytotoxicities against five different cancer cell lines (HeLa, Eca‐109, Biu‐87, Bel‐7402, and PANC‐1). However, none showed positive effects.

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Versicoamides F–H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

Cited by 37 publications

References 18 publications

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

Five New Records of the Family Aspergillaceae in Korea, Aspergillus europaeus, A. pragensis, A. tennesseensis, Penicillium fluviserpens, and P. scabrosum

Graphostromols A–K, Eleven New Chained Polyketides from the Deep‐Sea‐Derived Graphostroma sp

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