Versatile Triad Alliance: Bile Acid, Taurine and Microbiota

Duszka, Kalina

doi:10.3390/cells11152337

Cited by 25 publications

(24 citation statements)

References 428 publications

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“…[31] Studies show that taurine regulates the central nervous system function and modulates the intestinal micro-ecology. [32][33][34] Consistently, our study identified that taurine is abnormally accumulated in FS children, indicating its potential clinical value in FS treatment. Additionally, arginine has been documented to induce gut microbiota remodeling, which is closely related to brain development and function.…”

Section: Discussionsupporting

confidence: 82%

Changes of intestinal flora in children with febrile seizure

Yang

Tian

2023

Medicine

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Febrile seizure (FS) is a highly recurrent neuro-system disorder in children that affects their nervous system development and quality of life. However, the pathogenesis of febrile seizures remains unclear. Our study aims to investigate the potential differences in the intestinal flora and metabolomics between healthy children and those with FS. By examining the relationship between specific flora and different metabolites, we hope to shed light on the pathogenesis of FS. Fecal specimens were collected from healthy children (n = 15) and children with febrile seizures (n = 15), and 16S rDNA sequencing was conducted to characterize intestinal flora. Subsequently, fecal samples from healthy (n = 6) and febrile seizure children (n = 6) were used to characterize metabolomics using linear discriminant analysis of effect size, orthogonal partial least squares discriminant analysis, Kyoto Encyclopedia of Genes and Genomes (pathway enrichment analysis), and Kyoto encyclopedia of genes and genomes topology analysis. Liquid chromatography-mass spectrometry was used to identify metabolites in the fecal samples. The intestinal microbiome in the febrile seizure children significantly differed from that in the healthy children at the phylum level. Ten differentially accumulated metabolites (xanthosine, (S)-abscisic acid, N-palmitoylglycine, (+/−)-2-(5-methyl-5-vinyl-tetrahydrofuran-2-yl) propionaldehyde, (R)-3-hydroxybutyrylcarnitine, lauroylcarnitine, oleoylethanolamide, tetradecyl carnitine, taurine, and lysoPC [18:1 (9z)/0:0] were considered the potential febrile seizure markers. Three metabolic pathways (taurine metabolism; glycine, serine, and threonine metabolism; and arginine biosynthesis) were found essential in febrile seizure. Bacteroides were significantly correlated with the 4 differential metabolites. Adjusting the balance of intestinal flora may be an effective method for preventing and treating febrile seizures.Abbreviations: FS = febrile seizure, KEGG = Kyoto encyclopedia of genes and genomes, LC-MS = liquid chromatographymass spectrometry, LDA = linear discriminant analysis, LEfSe = linear discriminant analysis of effect size, NC = normal control, OPLS-DA = orthogonal partial least squares discriminant analysis, VIP = variable importance of the projection.

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Section: Discussionsupporting

confidence: 82%

Changes of intestinal flora in children with febrile seizure

Yang

Tian

2023

Medicine

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“…The major sources of taurine are endogenous synthesis and diet. The liver has been reported to be the main site of taurine biosynthesis, with two distinct pathways in which cysteine dioxygenase (CDO) and cysteine sulfate decarboxylase (CSAD) play important roles [ 2 , 3 ]. Since the vast majority of organisms have a low capacity for taurine biosynthesis, the level of taurine in the body is maintained by dietary intake and, consequently, the circulating level of taurine is significantly affected by diet [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Qian

et al. 2023

Biomedicines

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Taurine, an abundant free amino acid, plays multiple roles in the body, including bile acid conjugation, osmoregulation, oxidative stress, and inflammation prevention. Although the relationship between taurine and the gut has been briefly described, the effects of taurine on the reconstitution of intestinal flora homeostasis under conditions of gut dysbiosis and underlying mechanisms remain unclear. This study examined the effects of taurine on the intestinal flora and homeostasis of healthy mice and mice with dysbiosis caused by antibiotic treatment and pathogenic bacterial infections. The results showed that taurine supplementation could significantly regulate intestinal microflora, alter fecal bile acid composition, reverse the decrease in Lactobacillus abundance, boost intestinal immunity in response to antibiotic exposure, resist colonization by Citrobacter rodentium, and enhance the diversity of flora during infection. Our results indicate that taurine has the potential to shape the gut microbiota of mice and positively affect the restoration of intestinal homeostasis. Thus, taurine can be utilized as a targeted regulator to re-establish a normal microenvironment and to treat or prevent gut dysbiosis.

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“…In particular, taurine and indoleacetic acid showed downregulation outcomes when inulin was treated in this study. Taurine feeding has been reported to reduce fat accumulation and synthesis (Duszka, 2022; Lu et al., 2019), whereas indoleacetic acid is also related to lipid synthesis (Zhao et al., 2019). Taken together, these findings suggest that inulin may be involved in decreased energy metabolism in tapirs.…”

Section: Discussionmentioning

confidence: 99%

“…Prebiotic supplementation has shown to reduce waking cortisol and increase vigilance on emotional stimuli in human (Schmidt et al., 2015). Moreover, recent evidences have suggested that taurine also involved in the modulation of nerve system (Duszka, 2022). Overall, inulin as a potential key regulator of gut–brain pathway may affect the neuroendocrine metabolism in tapir.…”

Section: Discussionmentioning

confidence: 99%

Inulin supplementation increases the differential metabolites and metabolic pathway in Baird's tapirs (Tapirus bairdii)

Liu,

Hao

et al. 2023

Veterinary Medicine & Sci

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ObjectiveThe prevalence of prebiotic has increased substantially over the past decades. Little is known on its metabolic effects in zoo herbivores. We investigated the difference in faecal metabolites to characterize the composition and pathways involved after feeding inulin in zoo Baird's tapirs (Tapirus bairdii).MethodsFaecal samples were collected from before inulin treatment group and after treatment groups in six adult tapirs and analysed using untargeted liquid chromatography–mass spectrometry methods. The differential metabolites identified and metabolic pathways involved were analysed using KEGG annotation.ResultsThe results demonstrated significant alterations in faecal metabolites and metabolic pathways in comparison to the control group. The amounts of differential metabolites and metabolic pathways tended to enrich with time after the treatment. We found that tryptophan and purine metabolism were relevant to the important metabolic pathways of the metabolite differences.ConclusionsThe findings suggest that inulin may have potential applications in captive wildlife, which may provide insights into the effects of prebiotic supplementation on gut metabolites and highlights further research in this field.

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Versatile Triad Alliance: Bile Acid, Taurine and Microbiota

Cited by 25 publications

References 428 publications

Changes of intestinal flora in children with febrile seizure

Changes of intestinal flora in children with febrile seizure

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Inulin supplementation increases the differential metabolites and metabolic pathway in Baird's tapirs (Tapirus bairdii)

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