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“…1 A). In accord with previous studies (18), treatment with indomethacin tended to reduce the weight loss associated with LPS administration (Fig. 1 B, P ϭ 0.09 vs. vehicle/LPS at 1 day after treatment).…”
Section: Resultssupporting
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“…1 A). In accord with previous studies (18), treatment with indomethacin tended to reduce the weight loss associated with LPS administration (Fig. 1 B, P ϭ 0.09 vs. vehicle/LPS at 1 day after treatment).…”
Section: Resultssupporting
“…Unlike other agents that attenuate inflammation-induced anorexia, such as the phosphodiesterase inhibitor pentoxyphylline, calcium channel blockers, and glucocorticoids that block proximal events in the response to LPS (17,18,30), COX-2-selective drugs decrease anorexia without diminishing the cytokine response. Previous studies have demonstrated that NSAIDs may actually increase, rather than decrease, proximal events in the response during inflammation, such as induction of TNF-␣ (25), and our data extend this analysis by demonstrating no intermediate-to long-term reduction in IL-6 production.…”
Section: Discussionmentioning
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“…In our hands, nonselective pharmacological inhibition of COX by administration of indomethacin or paracetamol attenuated the pyretic and hypophagic effects of peripheral LPS and IL-1␤ (26,27). Selective inhibition of COX-2 blocks LPS-induced fever (7).…”
mentioning
“…LPS is a pathogenic agent that induces a moderate infection that is associated with a reduction in food consumption (Langhans et al, 1989). The rats (n=100) were deprived of food for 20 h and then injected with 100 µg/kg LPS.…”
Section: Effects Of Tf and Its Constituents On Lps-induced Anorexiamentioning