Ventricular Volume and Transmural Pressure Gradient in Normal Pressure Hydrocephalus

Is the placement of shunts in patients with idiopathic normal pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure

“…Published results on the relationship between the degree of ventricular dilation and outcome vary widely. 3,69,76 In the present study, the only significant correlation in ventricular dilation, as evaluated using the four ventricular indices and postoperative neuropsychological and functional statuses, was found between the ventricule score and the percentage of change on an attention test (Digit Span Forward).…”

Is the placement of shunts in patients with idiopathic normal pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure

“…Published results on the relationship between the degree of ventricular dilation and outcome vary widely. 3,69,76 In the present study, the only significant correlation in ventricular dilation, as evaluated using the four ventricular indices and postoperative neuropsychological and functional statuses, was found between the ventricule score and the percentage of change on an attention test (Digit Span Forward).…”

Imaging dementias

“…This aggressive treatment, aimed at counteracting the transmantle pressure gradients, is not without risks, and should be undertaken only in selected cases. Programmable shunts and the experience gained from larger series will probably improve our therapeutic approach to NPH patients [46]. …”

Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate

“…Transmantle pressure, the pressure difference between the lateral ventricle and the sub-arachnoid space, drives CSF circulation back and forth between the two regions. While an elevated transmantle pressure was once proposed as the cause for enlarged ventricles (ventriculomegaly) in iNPH [ 14 , 15 ], experiments have failed to confirm this hypothesis [ 16 , 17 ]. Some suggested a transient increase [ 18 – 20 ] or a minor elevation in transmantle pressure as the potential cause of ventriculomegaly [ 21 – 23 ].…”

Is the placement of shunts in patients with idiopathic normal pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure

“…Published results on the relationship between the degree of ventricular dilation and outcome vary widely. 3,69,76 In the present study, the only significant correlation in ventricular dilation, as evaluated using the four ventricular indices and postoperative neuropsychological and functional statuses, was found between the ventricule score and the percentage of change on an attention test (Digit Span Forward).…”

Imaging dementias

“…This aggressive treatment, aimed at counteracting the transmantle pressure gradients, is not without risks, and should be undertaken only in selected cases. Programmable shunts and the experience gained from larger series will probably improve our therapeutic approach to NPH patients [46]. …”

Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate

“…Transmantle pressure, the pressure difference between the lateral ventricle and the sub-arachnoid space, drives CSF circulation back and forth between the two regions. While an elevated transmantle pressure was once proposed as the cause for enlarged ventricles (ventriculomegaly) in iNPH [ 14 , 15 ], experiments have failed to confirm this hypothesis [ 16 , 17 ]. Some suggested a transient increase [ 18 – 20 ] or a minor elevation in transmantle pressure as the potential cause of ventriculomegaly [ 21 – 23 ].…”

Is the placement of shunts in patients with idiopathic normal pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure

“…Published results on the relationship between the degree of ventricular dilation and outcome vary widely. 3,69,76 In the present study, the only significant correlation in ventricular dilation, as evaluated using the four ventricular indices and postoperative neuropsychological and functional statuses, was found between the ventricule score and the percentage of change on an attention test (Digit Span Forward).…”

Imaging dementias

“…This aggressive treatment, aimed at counteracting the transmantle pressure gradients, is not without risks, and should be undertaken only in selected cases. Programmable shunts and the experience gained from larger series will probably improve our therapeutic approach to NPH patients [46]. …”

Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate

“…Transmantle pressure, the pressure difference between the lateral ventricle and the sub-arachnoid space, drives CSF circulation back and forth between the two regions. While an elevated transmantle pressure was once proposed as the cause for enlarged ventricles (ventriculomegaly) in iNPH [ 14 , 15 ], experiments have failed to confirm this hypothesis [ 16 , 17 ]. Some suggested a transient increase [ 18 – 20 ] or a minor elevation in transmantle pressure as the potential cause of ventriculomegaly [ 21 – 23 ].…”