Ventilation/perfusion SPECT in chronic obstructive pulmonary disease: an evaluation by reference to symptoms, spirometric lung function and emphysema, as assessed with HRCT

Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure

“…Previously in clinical studies, Jogi et al have demonstrated that V/Q SPECT is sensitive to COPD-related pathologies (13), and Suga et al have quantified the V/Q mismatch due to emphysema in a per-voxel manner (14). Our results affirm that V/Q methodologies, being functional measurements, are sensitive to early pathologic changes that lead to COPD but may not be apparent, even at a higher resolution, with anatomic imaging systems such as CT. Because V/Q imaging is a common nuclear medicine technique and SPECT/CT systems are increasingly used (21), V/Q measurement could play an important role in the diagnosis, treatment, and further understanding of COPD (13,22,23).…”

“…V/Q SPECT imaging, on the other hand, is a well-established nuclear medicine technique that provides spatial information regarding the 2 core processes of respiratory gas exchange, ventilation of alveolar units and perfusion of the pulmonary capillary beds (11), and the results of this technique correlate well with those derived from MIGET (12). SPECT V/Q is commonly used in the diagnosis of pulmonary embolism but has been shown to be sensitive to early indicators of COPD in addition to being capable of identifying comorbid disease and distinguishing pathophysiologic changes (13,14). Furthermore, coregistration of nuclear imaging data to CT images allows for greater insight into the anatomic position of lung dysfunction and structural information such as the distribution of emphysema.…”

Quantitative Ventilation/Perfusion Tomography: the Foremost Technique for Pulmonary Embolism Diagnosis

“…Garg et al (1983) found that the degree of abnormality on aerosol ventilation images significantly correlated to pulmonary function tests. In a recent paper, which evaluated the role of V/P SPECT in patients with COPD, it was shown that V/P SPECT correlated significantly both to traditional lung function tests as well as the extent of emphysema as measured with HRCT (Jögi et al, 2011). It was also shown that V/P SPECT could be used to characterize the severity of COPD.…”

Quantification and optimisation of lung ventilation SPECT images

“…Heterogeneous ventilation has been demonstrated in lungs of allergic individuals, cigarette smokers, asthmatics and COPD patients (Altes et al, 2001;Emami et al, 2013;Jogi et al, 2011;Samee et al, 2003;Sovijarvi et al, 1982;Tgavalekos et al, 2007;Venegas et al, 2005). These subjects suffer from narrow and/or closed airways in various extents.…”

“…Heterogeneous, uneven or patchy ventilation in lungs of allergic individuals, cigarette smokers, asthmatics and COPD patients have been demonstrated using various imaging techniques such as positron emission tomography (PET) (Tgavalekos et al, 2007;Venegas et al, 2005), magnetic resonance imaging (MRI) (Altes et al, 2001;Samee et al, 2003;Emami et al, 2013), planar scintigraphy images (Sovijarvi et al, 1982) and SPECT (Jogi et al, 2011). The amount of heterogeneous ventilation is correlated to disease advancement (Hedenstierna, 2000).…”