Venous Thromboembolism Risk and Adequacy of Prophylaxis in High Risk Pregnancy in the Arabian Gulf

Alsayegh, Faisal; Al-Jassar, Waleed; Wani, Salima; Tahlak, Muna; Albahar, Awatef; Kharusi, Lamya Al; Al-Tamimi, Halima; El-Taher, Faten; Mahmood, Naeema; Al‐Zakwani, Ibrahim

doi:10.2174/1570161113666151030105431

Cited by 15 publications

(15 citation statements)

References 29 publications

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“…The risk profile analysis of our patients revealed that obesity was the most prevalent risk factor, followed by multiparity. These findings are consistent with those from a large cross-sectional study in which obesity was manifest in 76% of the examined VTE cases, and multiparity was the second most prevalent risk factor observed in 33% of patients [10]. In another case-control study conducted among Sudanese pregnant and postpartum patients with VTE, it was found that family history, followed by multiparity and cesarean section delivery was the most significant risk factors (ORs: 7.4, 2.2, and 2, respectively) [11].…”

Section: Discussionsupporting

confidence: 91%

Pregnancy and Venous Thromboembolism: Risk Factors, Trends, Management, and Mortality

AlSheef

Alabbad

Albassam

et al. 2020

BioMed Research International

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Background. Pregnancy is one of the major risk factors for the development of venous thromboembolism (VTE). Objective. To elucidate the circumstances surrounding pregnancy-induced deep vein thrombosis (DVT) and pulmonary embolism (PE), assess potential factors triggering thrombosis (e.g., thrombophilia, obesity, age, parity, and family history), initial and long-term management, and assess recurrence rate and mortality for VTE in pregnant Saudi women. Methods. A retrospective chart review of 180 patients with objectively confirmed VTE (DVT, PE, or both) that occurred during pregnancy, or the postpartum period was conducted. All patients who experienced episodes of objectively confirmed VTE were included. Results. Overall, 180 patients were included. Further, 60% (n=109) and 40% (n=71) of the VTE cases occurred during the postpartum and antenatal periods, respectively. Cesarean section was the most prevalent risk factor among study participants (n=86 (47.8%)), followed by obesity (n=73 (40.6%)). The most common clinical presentations were lower leg pain (57.2%) and lower limb swelling (54.4%). VTE recurrences were observed in approximately 11% of the participants, and maternal mortality occurred in 2 (1.1%) cases. Conclusion. Pregnancy was the most common provoking factor for VTE in our study. Pregnant women should undergo formal, written assessments of risk factors for VTE at the first visit and delivery. Larger studies with a randomized design, and control groups are required to confirm the current findings.

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Section: Discussionsupporting

confidence: 91%

Pregnancy and Venous Thromboembolism: Risk Factors, Trends, Management, and Mortality

AlSheef

Alabbad

Albassam

et al. 2020

BioMed Research International

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“…16 However, perceived VTE risk in the present study was higher than that reported in two previous cross-sectional studies. In a noninterventional, multinational study conducted at seven centers in the Arabian Gulf countries, 32% (1,337 of 4,131) of the eligible pregnant women were at VTE risk, 17 almost equal to two-thirds of that observed for the Middle-East in the present study. In another study in Ireland, 40% (145 of 364) of the pregnant and postpartum women were at risk, 18 nearly half of that observed for Eurasia in the present study.…”

Section: Discussionsupporting

confidence: 37%

Risk Assessment and Management of Venous Thromboembolism in Women during Pregnancy and Puerperium (SAVE): An International, Cross-sectional Study

Gris

Aoun

Rzaguliyeva³

et al. 2018

TH Open

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Keywords► pregnancy ► prophylaxis ► puerperium ► risk assessment and management ► venous thromboembolism AbstractThe clinical burden of obstetric venous thromboembolism (VTE) risk is inadequately established. This study assessed the prevalence and management of VTE risk during pregnancy and postpartum outside the Western world. This international, noninterventional study enrolled adult women with objectively confirmed pregnancy attending prenatal care/obstetric centers across 18 countries in Africa, Eurasia, Middle-East, and South Asia. Evaluations included proportions of at-risk women, prophylaxis as per international guidelines, prophylaxis type, factors determining prophylaxis, and physicians' awareness about VTE risk management guidelines and its impact on treatment decision. Data were analyzed globally and regionally. Physicians (N ¼ 181) screened 4,978 women, and 4,010 were eligible. Of these, 51.4% were at risk (Eurasia, 90%; South Asia, 19.9%), mostly mild in intensity; >90% received prophylaxis as per the guidelines (except South Asia, 77%). Women in Eurasia and TH Open 2018;2:e116-e130.

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“…There can be more than one risk factor for VTE in one patient. Obesity and multiple pregnancies were the risk factors for VTE in Middle East population [5]. Peripartum Pulmonary Embolism DOI: http://dx.doi.org/10.5772/intechopen.84688…”

Section: Risk Factorsmentioning

confidence: 99%

“…Peripartum thromboembolism common, as still the prophylaxis, is adequately administered in high-risk patients [5]. Those patients with a higher risk of thromboembolism during pregnancy and peripartum should receive the thromboprophylaxis to prevent proper thromboembolisms (Figure 5).…”

Section: Preventionmentioning

confidence: 99%

Peripartum Pulmonary Embolism

Shaikh¹,

Ummunnisa²,

Chanda³

et al. 2020

Embolic Diseases - Evolving Diagnostic and Management Approaches

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Pregnancy and peripartum increase the risk of venous thromboembolism (VTE) by many folds. Interestingly, the VTE is more common during the pregnancy, whereas the pulmonary embolism is more frequent in postpartum period. There are various risk factors for the VTE and pulmonary embolism in these patients. The important risks are improper thromboprophylaxis, obesity, and multigravida. The clinical parameters and the d-dimer are not used for diagnosis of thromboembolism during pregnancy and in the postpartum period. The compression ultrasonography (CUSG) is commonly used for VTE diagnosis; for the pulmonary embolism diagnosis, one has to consider the radiation hazard to the fetus as well as to the mothers. Ventilation/perfusion scan is the imaging of choice for patient who has respiratory signs with normal chest radiograph. If chest X-ray is abnormal with suspicion of peripartum pulmonary embolism (PPE), the choice should be computed tomographic angiography. Heparin and its derivatives remained the anticoagulation of choice for the treatment of VTE as well as the PPE, as it is a shorter acting, easy to reverse with protamine sulfate. Proper thromboprophylaxis is the key for prevention of VTE and peripartum pulmonary embolism.

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Venous Thromboembolism Risk and Adequacy of Prophylaxis in High Risk Pregnancy in the Arabian Gulf

Cited by 15 publications

References 29 publications

Pregnancy and Venous Thromboembolism: Risk Factors, Trends, Management, and Mortality

Pregnancy and Venous Thromboembolism: Risk Factors, Trends, Management, and Mortality

Risk Assessment and Management of Venous Thromboembolism in Women during Pregnancy and Puerperium (SAVE): An International, Cross-sectional Study

Peripartum Pulmonary Embolism

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