Venous thromboembolism prevention in gynecologic cancer surgery: A systematic review

Venous thromboembolism prophylaxis in cancer patients — guidelines focus on surgical patients

“…In a systematic review of literature, 11 randomized clinicaltrials related to the use of low molecular weight heparin and intermittent pneumatic compression in gynecologic cancer surgery were identified [141]. In the analysis of the studies on the effectiveness of the low--dose unfractionated heparin, a significant decrease in the incidence of DVT in the comparison to the control group (RR = 0.58, 95% CI 0.35-0.95) in this clinical settings was reported.…”

Postoperative Thromboembolism in Gynecologic Oncology Patients. Still a Lethal but Preventable Complication

“…However, LMW heparin cost is greater than that of unfractionated heparin. Gynecologic patients undergoing major surgery received equal benefit in prevention of DVT with LMW and LDUH [29]. In cases of renal dysfunction and clearance impairment (GFR<30 ml/min), drug accumulation results in an increased risk of bleeding.…”

Supportive care for women with gynecologic cancers

“…The best method of prophylaxis remains debatable. Prophylaxis with sequential compression devices, unfractionated heparin, or low-molecular-weight heparin, is recommended [31]. Second, when addressing 'tumor fever', it is critical to ruleout other causes of cancer-related fever.…”