Venom ophthalmia caused by venoms of spitting elapids such as the Mozambique Spitting Cobra (Naja mossambica) is seen in regions where people live in close proximity to elapids, such as in the KwaZulu Natal region of South Africa. We report such a case in a 43-year-old woman who presented to Mosvold Hospital, a district hospital in South Africa. Clinical features and best practice management of venom ophthalmia will be discussed.