Vehicles in Topical Dermatologic Therapy

Volatile oils are frequently employed in the local treatment of pain. 1,8-Cineole, the principal component of eucalyptus oil, was used as a model substance to determine whether this active component can be detected in effective amounts at the target area in the skeletal muscles after dermal application. The investigation showed surprisingly large differences depending on the manner of application. The relative bioavailability of the model substance 1,8-cineole obtained by using an applicator was 320% as compared with that obtained by using an occlusive dressing. This has practical effects on the dosage and on the frequency of application.

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Vehicles in Topical Dermatologic Therapy

Cited by 13 publications

References 19 publications

Topical treatments for eczema: a network meta-analysis

Topical treatments for eczema: a network meta-analysis

The In Vitro Fungistatic Action of Some Nitrofuran Derivatives

Hautdurchdringung ätherischer Öle. Pharmakokinetische Untersuchungen

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