VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

Wu, Xianjie; Jing, Jing; Zhang, Lu; Zheng, Min

doi:10.12659/msmbr.914570

Cited by 5 publications

(4 citation statements)

References 17 publications

(21 reference statements)

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“…VEGF from dermal papilla attracts adjacent blood vessel to supply vascular-derived growth factors to the hair follicles. VEGF also stimulates adjacent cells, such as outer root sheath cells, matrix progenitor cells, sebaceous glands, sweat glands, and epidermis to make the hair follicle fully matured and the hair shaft differentiated [34]. As shown in Figure 5, the protein level of VEGF was up-regulated by the D-panthenol treatment.…”

Section: D-panthenol Stimulated Vegf Expression In Cultured Hdpcsmentioning

confidence: 92%

Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

Shin

Kim

Choi

et al. 2021

CIMB

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Dexpanthenol (D-panthenol) is a precursor of vitamin B5 (pantothenic acid) and is widely used for dietary supplements and topical applications. D-panthenol has long been used in hair care products for the purpose of anti-hair loss, its effects and the underlying mechanisms, however, were barely reported. In this study, the effects of D-panthenol on human hair follicle cells, including dermal papilla cells (hDPCs) and outer root sheath cells (hORSCs), were investigated. D-panthenol enhanced the cell viability, increasing the cellular proliferation marker Ki67 in cultured hDPCs. The markers for apoptosis (Caspase3/9) and cell senescence (p21/p16), reported to be expressed in aged or resting phase follicles, were significantly reduced by D-panthenol. Anagen-inducing factors (ALP; β-catenin; versican), which trigger or elongate the anagen phase, were stimulated by D-panthenol. On the other hand, D-panthenol reduced TGF-β1 expressions in both mRNA and protein levels. The expression of VEGF, which is important for peripheral blood vessel activation; was up-regulated by D-panthenol treatment. In cultured hORSCs, cell proliferation and viability were enhanced, while the mRNA expression of cell senescence markers (p21/p16) was significantly down-regulated. The expressions of both VEGF and its receptor (VEGFR) were up-regulated by D-panthenol. In conclusion, our data suggest that the hair growth stimulating activity of D-panthenol was exerted by increasing the cell viability, suppressing the apoptotic markers, and elongating the anagen phase in hair follicles.

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Section: D-panthenol Stimulated Vegf Expression In Cultured Hdpcsmentioning

confidence: 92%

Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

Shin

Kim

Choi

et al. 2021

CIMB

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“…Sebaceous glands are complex structures, and their genesis and homeostasis are dependent on mesenchymal signals, including EGFR and VEGF, and regulatory T cells that are also capable of inducing follicularderived and epidermal-derived sebaceous glands from resident stem cells. [21][22][23][24] The sebaceous glands are directly connected to the infundibular canal through cuticular-lined sebaceous ducts forming an axis representing a complex homeostatically controlled structure. Sebum production is more prominent than trichogenesis in sebaceous follicles.…”

Section: Structural and Functional Homeostasis Of Hair Follicles And ...mentioning

confidence: 99%

“…The PD-1/PD-L1, VEGF/ VEGFR, and EGFR/amphiregulin axes govern multiple pathways of signal transduction. [22][23][24][25] These pathways are widely expressed and are key in maintaining skin homeostasis, including those related to the follicular infundibulum and sebaceous glands. Repair Tregs have been identified that are integrated to these signal transduction pathways forming a complex wound healing and follicular repair system encompassing infundibular committed stem cell.…”

Section: Biological Antitumor Inhibitors and The Paradoxical Developm...mentioning

confidence: 99%

Eruptive Necrotizing Infundibular Crystalline Folliculitis: An Expression of an Abortive Sebaceous Follicular Repair Pathway Linked to Committed Infundibular Stem Cells?

Kossard

2021

The American Journal of Dermatopathology

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Necrotizing infundibular crystalline folliculitis is a rare entity, which is a distinctive clinical and histopathological entity. Eruptive yellow waxy umbilicated folliculocentric plugs clinically correspond to pale crystalline filaments embedded in an amorphous sebum-rich material. Remarkably, only the superficial infundibular ostia remain, and the distended cavity is devoid of a follicular or sebaceous gland remnant. The pathogenesis of this enigmatic event remains to be established. The emergence of necrotizing infundibular crystalline folliculitis (NICF) as a paradoxical side effect of antitumor inhibitors epidermal growth factor receptor vascular endothelial growth factor and more recently programmed death-1 represents the expression of altered molecular pathways that underpin the pathogenesis of NICF. To explore these pathways, it is necessary to explore the hierarchy of follicular stem cells, particularly the potential role of committed infundibular stem cells that play a key role in wound healing. Committed infundibular stem cells are closely linked to the sebaceous gland stem cell axis, and this has relevance in the process of homeostatic repair of sebaceous follicles in the wake of folliculitis. The unscheduled modulation of this infundibular homeostatic sebaceous repair axis by epidermal growth factor receptor vascular endothelial growth factor, and programmed death-1 may lead to an aberrant outcome with metaplasia of infundibular keratinocytes to sebocytes. In the absence of sebaceous gland differentiation, these metaplastic infundibular sebocyte cells would lead to the consumption and loss of the infundibulum as a result of holocrine sebum production. This conceptual pathogenic pathway for NICF is constructed by incorporating recent advances in the fields of follicular stem cells, wound repair, follicular homeostasis, regulatory T cells, and molecular pathways linked to the biologicals inducing NICF.

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“…Insulin-like growth factor 1 (IGF-1), a well-known hair growth-promoting factor, controls the hair growth phase and hair shaft differentiation, in addition to preventing anagen-to-catagen transition [ 17 ]. Additionally, vascular endothelial growth factor (VEGF), which is widely recognized as a hair growth-promoting factor, influences hair shaft differentiation in the hair growth phase by promoting the proliferation and differentiation of hair root cells for hair shaft formation [ 18 ]. Transforming growth factor-beta 1 (TGF-β1) inhibits hair shaft formation and development by inducing apoptosis, increasing telogen hair follicles, and promoting the transition of growing hair follicles into catagen hair follicles [ 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

Hwang,

Park,

Lee

2023

Marine Drugs

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Fish-derived collagen hydrolysate (CH) has shown promise in improving hair and skin health. Therefore, this study sought to comprehensively assess the effects of CH extracted from Mozambique tilapia (Oreochromis mossambicus) scales on hair and skin using in vitro and in vivo models. Human dermal papilla cells (hDPCs) were used for antioxidant and gene expression analyses, while C57BL/6 mice were orally administered CH for six weeks to assess hair growth patterns. The mice were divided into four groups: negative control (NC; distilled water), positive control (PC; 1 mg/kg finasteride), CH500 (500 mg/kg BW CH), and CH1000 (1000 mg/kg BW CH). CH mitigated catalase activity reduction in hDPCs, increased IGF-1 and VEGF levels, and decreased TGF-β1, TNF-α, and IL-1β expression. In vivo, CH treatment improved hair growth index, length, diameter, weight, and density. Scanning electron microscopy revealed reduced hair damage. Moreover, CH up-regulated IGF-1, VEGF, Elastin, and HAS2 mRNA expression while down-regulating TNF-α and IL-1β. CH enhanced hair shine, growth, and skin health while alleviating inflammation. These findings demonstrate the potential of CH in alleviating oxidative stress, promoting hair growth, and enhancing skin health, both in vitro and in vivo. Fish-derived CH offers a cost-effective and bioavailable option for improving hair and skin health.

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VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

Cited by 5 publications

References 17 publications

Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

Eruptive Necrotizing Infundibular Crystalline Folliculitis: An Expression of an Abortive Sebaceous Follicular Repair Pathway Linked to Committed Infundibular Stem Cells?

Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

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