VEGF 936 C/T gene polymorphism in renal transplant recipients: Association of the T allele with good graft outcome

Güneşaçar, Ramazan; Opelz, Gerhard; Erken, Eren; Pelzl, Steffen; Döhler, Bernd; Ruhenstroth, Andrea; Süsal, Caner

doi:10.1016/j.humimm.2007.03.015

Cited by 20 publications

(21 citation statements)

References 19 publications

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“…This study revealed that allele frequencies of the VEGF 936C > T polymorphism in our study control group were not significantly different from other Asian populations. On the other hand, there was a racial difference in the frequency of the T allele: 0.167 in Canadians, 0.161 in Polish (only female group), 0.140 in Americans, and 0.091 in Germans 6,26,38,39. Earlier differences in the literature might have been results may be due to different genetic backgrounds.…”

Section: Discussionmentioning

confidence: 94%

Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936C > T) Gene and Patients with Stomach Cancer

et al. 2008

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PurposeAngiogenesis plays an important role in the growth, progression, and metastasis of tumors. Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poor survival in several cancers. We investigated the present case-control study to determine whether there is an association between the VEGF 936C > T polymorphism and stomach cancer.Patients and MethodsThe association of functional single nucleotide polymorphisms (SNPs) of the VEGF gene with stomach cancer development was evaluated in a case-control study of 154 Korean stomach cancer patients. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.ResultsOur results revealed significant association of T allele-bearing genotypes with increased risk for stomach cancer development. Genotype frequencies of the VEGF 936C > T polymorphisms were significantly different between patient and control groups (CT, AOR: 2.007, 95% CI: 1.277 - 3.156, TT, AOR: 4.790, 95% CI: 1.174 - 19.539, CT + TT, AOR: 2.147, 95% CI: 1.382 - 3.337). When stratified by gender and age, genotype frequencies were significantly different for stomach cancer in women and in patients younger than 55 years (in women, CT, OR: 3.049, 95% CI: 1.568 - 5.930, CT+TT, OR: 3.132, 95% CI: 1.638 - 5.990; in < 55 years, CT, OR: 3.306, 95% CI: 1.413 - 7.732, CT + TT, OR: 3.967, 95% CI: 1.729 - 9.104). In addition, this association partially remained in cases with intestinal and diffuse-type stomach cancer.ConclusionOur present study suggests that the VEGF 936C > T polymorphism is a susceptibility factor for stomach cancer, at least in Korean.

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Section: Discussionmentioning

confidence: 94%

Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936C > T) Gene and Patients with Stomach Cancer

et al. 2008

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“…A risk association for the VEGF 936 T allele has been reported earlier in many other diseases like endometriosis [12], oral cancer [13] and age-related macular degeneration [14]. Previous studies have also shown lower circulating levels of VEGF to be associated with the 936 T allele [10,15,16]. …”

Section: Discussionmentioning

confidence: 81%

Impact of Vascular Endothelial Growth Factor Single Nucleotide Polymorphism Association on Acute Renal Allograft Rejection

Prakash

Agrawal

Kumar

et al. 2015

Nephron

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Background: Vascular endothelial growth factor (VEGF) is a cytokine which plays an important role in the division, proliferation and migration of endothelial cells. In the kidney, VEGF expression is found in glomerular podocytes and in tubular epithelial cells, which may result in acute inflammatory reactions. Methods: The role of VEGF gene polymorphisms (-2578 C/A, -2549 18 bp Ins/Del, -1154 G/A and +936 C/T) was investigated in 272 patients who underwent renal transplantation. ARMS-PCR and PCR-RFLP were used. Patients were categorized into acute allograft rejection (n = 76) and nonrejection (n = 196). Results: The VEGF -1154 GG genotype and the +936 T allele were found to be susceptible to acute rejection (AR). T-A-A-I, T-A-A-D, T-G-C-I and C-A-A-I haplotypes revealed a predisposition among AR cases. In silico analysis revealed +936 T as a significant allele involved in the transcription regulation. Conclusion: These results highlight the role of VEGF polymorphisms in acute allograft rejection.

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“…Gunesacar et al genotyped the single SNP VEGFA rs3025039 (reported as +936 C/T), located in the 3′ untranslated region in cases who had lost their graft in the first year post-transplant, and controls with a well functioning graft at the same time point (n = 265 cases, n = 290 controls) [39]. Subjects were sourced from the Collaborative Transplant Study bio-bank, were Caucasian and were all primary kidney recipients receiving deceased donor kidneys.…”

Section: Positive Associations In Kidney Transplant Recipientsmentioning

confidence: 99%

Genetic polymorphisms in the immune response: A focus on kidney transplantation

Stojanova

Pouché

Picard

2016

Clinical Biochemistry

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VEGF 936 C/T gene polymorphism in renal transplant recipients: Association of the T allele with good graft outcome

Cited by 20 publications

References 19 publications

Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936C > T) Gene and Patients with Stomach Cancer

Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936C > T) Gene and Patients with Stomach Cancer

Impact of Vascular Endothelial Growth Factor Single Nucleotide Polymorphism Association on Acute Renal Allograft Rejection

Genetic polymorphisms in the immune response: A focus on kidney transplantation

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