VDR gene polymorphisms are associated with the increased susceptibility to COVID‐19 among iranian population: A case‐control study

Jafarpoor, Ali; Jazayeri, Seyed Mohammad; Bokharaei‐Salim, Farah; Ataei‐Pirkooh, Angila; Ghaziasadi, Azam; Soltani, Saber; Sadeghi, Ahmadreza; Marvi, Shima Sadeghipoor; Poortahmasebi, Vahdat; Khorrami, Seyed Mahmood Seyed; Hasanzad, Mandana; Parsania, Negar; Nagozir, Sina; Mokhtari, Narges; Parsania, Ali; Bahrami, Asma; Nadjarha, Mohammad Hossein; Pakzad, Reza; Parsania, Masoud

doi:10.1111/iji.12585

Cited by 18 publications

(14 citation statements)

References 47 publications

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“…Apaydin et al indicated that most participants who were admitted to the intensive care unit (ICU) had the TT genotype for TaqI rs731236 polymorphism, whereas the TC genotype was more common in the non-ICU–admitted groups [ 20 ]. In addition, two studies in Iran did not report any relationship between this polymorphism and the COVID-19 mortality rate [ 27 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Albu-Mohammed

Anvari

Fateh

2022

Genes

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A lack of vitamin D is a potential risk factor for coronavirus disease (COVID-19). Variants in the Vitamin D Receptor (VDR) gene, such as BglI rs739837 and TaqI rs731236, are associated with various viral infection progressions. This study aimed to evaluate the relationship between the BglI rs739837 and TaqI rs731236 polymorphisms and the mortality rate of COVID-19 based on severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) variants. The genotyping of BglI rs739837 and TaqI rs731236 genotypes was analyzed using the polymerase chain reaction–restriction fragment length polymorphism in 1734 improved and 1450 deceased patients positive for SARS-CoV-2. In this study, the rate of COVID-19 mortality was correlated with TaqI rs731236 TC and CC in the α variant and with TaqI rs731236 CC in the Delta variant, whereas no relationship was found in the Omicron BA.5 variant. In addition, the rate of COVID-19 mortality was associated with BglI rs739837 GT and TT in the Omicron BA.5 variant, while there was no association between BglI rs739837 and COVID-19 mortality in the α and Delta variants. The TG haplotype was more common in all SARS-CoV-2 variants, while the CT haplotype was associated with COVID-19 mortality in the Delta and Omicron BA.5 variants. In conclusion, this study indicated that the impacts of BglI rs739837 and TaqI rs731236 polymorphisms were related to SARS-CoV-2 variants. However, further research is still needed to approve our findings.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Albu-Mohammed

Anvari

Fateh

2022

Genes

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“…Based on this, VDR gene SNPs are considered potentially significant in the study of COVID-19 [ 70 ]. Currently, there are several publications considering rs2228570 as a factor influencing the susceptibility, clinical symptoms and severity of COVID-19, but their number is small [ 33 , 40 , 41 , 42 ]. Abdollahzadeh et al revealed the association of SNP rs2228570 (FokI) with fever and arterial hypertension in severe/critical patients [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…The CT (heterozygous) genotype has been significantly associated with increased likelihood of COVID-19 compared to CC (homozygous reference standard). In addition, the T allele is also associated with a high susceptibility to SARS-CoV-2 infection [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there is enough research on the effect of rs2228570 on predisposition to various diseases, such as atopic bronchial asthma [ 27 ], acute viral bronchiolitis [ 35 ], tuberculosis [ 36 , 37 ], dengue virus infection [ 38 ], respiratory syncytial virus-related disease [ 39 ] and others. There are publications studying the potential impact of genetic variations in the VDR gene (including rs2228570) on COVID-19 susceptibility and severity, but their number is small and the results differ significantly [ 33 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

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Plasma 25-Hydroxyvitamin D Level and VDR Gene Single Nucleotide Polymorphism rs2228570 Influence on COVID-19 Susceptibility among the Kazakh Ethnic Group—A Pilot Study

Protas

Pogossyan

et al. 2023

Nutrients

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Low plasma levels of the vitamin D metabolite 25-hydroxyvitamin D [25(OH)D] and the vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) have been associated with the body’s susceptibility to infectious diseases, including COVID-19. In this pilot retrospective study, representatives of the Kazakh population (central Kazakhstan) were divided into groups based on the test for IgM and IgG for coronavirus infection. We compared the 25(OH)D plasma levels and concluded that the COVID-19-positive group values (25.17 ng/mL ± 16.65) were statistically lower (p = 0.0114) compared to the COVID-19-negative ones (35.58 ng/mL ± 20.67). There was no association between age, gender and 25(OH)D concentration within the groups (p > 0.05). The genotyping of rs2228570 was performed using a TaqMan Real-Time PCR assay. Allele C predominated among the COVID-19-negative participants and significantly reduced the likelihood of coronavirus infection (p < 0.0001; OR = 0.0804; 95% CI 0.02357–0.2798). There were no statistically significant differences in the frequencies of the A, G and T alleles in the studied groups (p > 0.05). The GG genotype of rs2228570 was associated with a 4.131-fold increased likelihood of COVID-19 infection (p = 0.0288; χ2 = 5.364; OR = 4.131; 95% CI 1.223–13.71). Comprehensive studies are required to determine whether low 25(OH)D plasma concentrations and genetic background represent a risk factor for COVID-19 infection.

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“…

Dear Editor, we would like to share ideas on the publication 'VDR gene polymorphisms are associated with the increased susceptibility to COVID-19 among Iranian population: A case-control study' (Jafarpoor et al, 2022). Jafarpoor et al discovered that a VDR polymorphism (rs2228570) may impact individual susceptibility to COVID-19.

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confidence: 99%

VDR gene polymorphisms and susceptibility to COVID‐19: Correspondence

Sookaromdee¹,

Wiwanitkit

2022

Int J Immunogenetics

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VDR gene polymorphisms are associated with the increased susceptibility to COVID‐19 among iranian population: A case‐control study

Cited by 18 publications

References 47 publications

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Plasma 25-Hydroxyvitamin D Level and VDR Gene Single Nucleotide Polymorphism rs2228570 Influence on COVID-19 Susceptibility among the Kazakh Ethnic Group—A Pilot Study

VDR gene polymorphisms and susceptibility to COVID‐19: Correspondence

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