2021
DOI: 10.3389/fphys.2021.742839
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Abstract: Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage dependent anion channels (VDAC). The closed states of VDAC block the passage of anionic metabolites, and increase the flux of small cations, including calcium. Consequently, physiological or pharmacological regulation of VDAC opening, by conditioning the magnitude o… Show more

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Cited by 26 publications
(9 citation statements)
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References 140 publications
(156 reference statements)
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“…ATP deficiency can be caused by defects in transport of ATP generated in the mitochondrial matrix into the cytoplasm, which is mediated by adenine nucleotide translocase (ANT) family proteins and voltage-dependent anion channels (VDACs). 40 , 41 We examined the expression of Slc25a2, a major ANT, and Vdac1, a major VDAC, in mitochondria-enriched protein fractions of Tomm7(D/D) mice; however, we did not find significant changes in their abundance ( Figure S11 ). The bioenergetic dysfunction and the increased oxygen consumption with normal response to oligomycin, a proton transport inhibitor of complex V, suggest that there is a dissociation between proton transport and catalytic activity of complex V. Complex V consists of two rotary motors, the membrane-bound F 0 that mediates proton transport and F 1 that is responsible for ATP synthesis.…”
Section: Main Textmentioning
confidence: 90%
“…ATP deficiency can be caused by defects in transport of ATP generated in the mitochondrial matrix into the cytoplasm, which is mediated by adenine nucleotide translocase (ANT) family proteins and voltage-dependent anion channels (VDACs). 40 , 41 We examined the expression of Slc25a2, a major ANT, and Vdac1, a major VDAC, in mitochondria-enriched protein fractions of Tomm7(D/D) mice; however, we did not find significant changes in their abundance ( Figure S11 ). The bioenergetic dysfunction and the increased oxygen consumption with normal response to oligomycin, a proton transport inhibitor of complex V, suggest that there is a dissociation between proton transport and catalytic activity of complex V. Complex V consists of two rotary motors, the membrane-bound F 0 that mediates proton transport and F 1 that is responsible for ATP synthesis.…”
Section: Main Textmentioning
confidence: 90%
“…From a pharmacological perspective, the success of modulating VDAC opening is most likely to occur if the three isoforms are targeted simultaneously. However, VDAC isoform specificity and lack of identifiable druggable sites, have been big obstacles for the development of drugs regulating VDAC [ 32 , 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…In this way, the Warburg effect can be activated, resulting in cancer cell aerobic glycolysis. Erastin’s ability to control VDAC opening will have a substantial impact on mitochondrial metabolism, according to this study [ 26 ]. An increase in oxidative phosphorylation will lead to an increase in ROS generation and a reversal of the Warburg phenotype, which is associated with aerobic glycolysis.…”
Section: Mechanism Of Ferroptosismentioning
confidence: 99%