Journal of Cell Biology volume 217, issue 8, P2813-2830 2018 DOI: 10.1083/jcb.201706041 View full text
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Georg Hilfenhaus, Dai Phuong Nguyen, Jonathan Freshman, Divya Prajapati, Feiyang Ma, Dana Song, Safiyyah Ziyad, Myriam Cuadrado, Matteo Pellegrini, Xosé R. Bustelo, M. Luisa Iruela-Arispe

Abstract: Through multiple cell-cell and cell-matrix interactions, epithelial and endothelial sheets form tight barriers. Modulators of the cytoskeleton contribute to barrier stability and act as rheostats of vascular permeability. In this study, we sought to identify cytoskeletal regulators that underlie barrier diversity across vessels. To achieve this, we correlated functional and structural barrier features to gene expression of endothelial cells (ECs) derived from different vascular beds. Within a subset of identif…

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