Vasotocin – A new player in the control of oocyte maturation and ovulation in fish

Joy, K.P.; Chaube, Radha

doi:10.1016/j.ygcen.2015.02.013

Cited by 37 publications

(32 citation statements)

References 72 publications

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“…The question of whether [V8] isotocin is a functionally relevant nonapeptide has been investigated in our laboratory. It has been shown previously that Vt and Itb are involved in ovarian functions such as steroidogenesis, oocyte maturation, hydration, prostaglandin secretion and ovulation and, in this regard, Vt is more potent than Itb with respect to mediating these functions . The high expression of the pro‐ita gene in the late recrudescent phase (pre‐spawning and spawning phases) may imply its involvement in ovarian functions, similar to Itb.…”

Section: Discussionmentioning

confidence: 95%

Molecular cloning and characterisation of an isotocin paralogue ([V8] isotocin) in catfishes (superorder Ostariophysi): Origin traced likely to the fish‐specific whole genome duplication

Banerjee

Chaube

Joy

2018

J Neuroendocrinology

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The present study reports the molecular cloning of a previously uncharacterised neurohypophyseal nonapeptide precursor cDNA in two catfish species: Heteropneustes fossilis and Clarias batrachus. The deduced nonapeptide is CYISNCPVG ([V8] isotocin), which has not been reported in any vertebrate till date. Phylogenetic and conserved synteny analyses showed the gene to have originated from the isotocin precursor (pro‐it) gene by fish‐specific whole genome duplication (3R). The two isotocin lineages have been designated as pro‐ita (new gene) and pro‐itb (conventional it gene). All teleost groups may not possess both pro‐ita and pro‐itb and the pattern of losses/retention was found to be lineage‐specific. Quantitative reverse transcriptase‐polymerase chain reaction studies showed the expression of the pro‐ita gene in the brain and ovary of H. fossilis. In situ hybridisation studies localised the pro‐ita transcripts in the nucleus preopticus of the hypothalamus and the follicular layer (theca‐granulosa) of oocytes, comprising tissues in which pro‐itb and vasotocin precursor (pro‐vt) mRNA expression was previously reported. The transcript levels varied with the reproductive stage and a high abundance was found in both brain and ovary during the breeding phase. The substitution of valine in place of isoleucine at the eighth position in Ita may have modified the ligand‐receptor interaction, leading to sub‐functionalisation and the retention of the gene in catfishes.

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Section: Discussionmentioning

confidence: 95%

Molecular cloning and characterisation of an isotocin paralogue ([V8] isotocin) in catfishes (superorder Ostariophysi): Origin traced likely to the fish‐specific whole genome duplication

Banerjee

Chaube

Joy

2018

J Neuroendocrinology

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“…Ovarian-derived vasotocin is a potential mediator of gonadotropin-induced OM, at least in the Indian catfish (review: Joy and Chaube, 2015). The MIS, 17,20βP, increased ovarian vasotocin levels in vitro, and reciprocally, vasotocin, which alone can induce OM, stimulated ovarian 17,20β levels, suggesting the existence of an autocrine positive feedback loop in which vasotocin and MIS each stimulate synthesis of the other (Joy and Chaube, 2015).…”

Section: F Transition From Vitellogenesis To Final Oocyte Maturationmentioning

confidence: 91%

“…germinal vesicle breakdown) (Bobe et al, 2006). Conversely, expression of the aqp1ab gene in fully-grown follicles of Indian catfish, which do not undergo extensive hydration, was stimulated by vasotocin and hCG, with further work suggesting that the effects of hCG may be mediated via vasotocin (Chaube et al, 2011;Joy and Chaube, 2015). Thus, while the involvement of Aqp1ab in the Lh-induced processes that lead to ooplasm hydration appears to be a conserved feature of teleost oocytes, the hormonal regulation and timing of expression of the gene might be more diverse (review: Cerdà et al, 2013).…”

Section: F Transition From Vitellogenesis To Final Oocyte Maturationmentioning

confidence: 99%

Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development

et al. 2017

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The production of fertile eggs with the capacity to develop into larvae and subsequently into marketable fish is centrally important to the aquaculture industry. This entails not only the programmed production of large numbers of eggs, but also high quality eggs with the potential to support normal development and high survival of offspring to juvenile and later stages of development and growth. Numerous studies highlight the maternal contributions to the development of embryos, including transcripts that regulate cell division and determine oocyte polarity, pattern development during early and late embryonic stages and the transition from maternal to zygotic gene expression and translation. Since most fish embryos develop independently within an enclosed egg envelope, they rely on compounds deposited within the oocytes during their various stages of development. In addition to regulatory nucleic acids (maternal DNA and RNA), these include proteins and other compounds that contribute to the structure and function of the egg envelope and the bulk molecular cargo that will be used as a source of cellular energy and structural components for formation of embryos and larvae. These latter components notably include yolk lipids and proteins deposited during oocyte growth and water acquired at the same time and during cytoplasmic maturation. In this review we highlight recent advances made in revealing the transcripts deposited within the oocyte that contribute to the structural and morphological development of the embryo, and to the regulation of gene expression and translation during oocyte development. Significant advances have been made in revealing the molecular mechanisms of lipid accumulation and metabolism within the oocyte, the intricacies of yolk protein formation via endocytosis of multiple yolk precursor proteins by multiple oocyte receptors, and the complex machinery supporting massive accumulation of water by maturing oocytes of many species. Additionally, many advances have been made in our understanding of the endocrine regulation of all of these processes during oogenesis. We provide here an overview of recent advances in our knowledge on these various aspects of oogenesis and identify several gaps in our knowledge for future studies.

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“…Studies to date have focused on the hypothalamic functions of neuropeptides and monoamine neurotransmitters in regulating sex change, despite their receptors also being widely detected in the gonad. Direct effects of these neurochemicals on gonadal function and steroidogenesis are currently unstudied in sex‐changing fish, but have been reported in some gonochoristic species (reviewed in McGuire and Bentley, ; Joy et al, ; Joy and Chaube, ). For example, recent studies in catfish suggest direct gonadal innervation by the sympathetic systems (Chourasia et al, ), which may support ovarian catecholaminergic (dopamine and norepinephrine) activities that contribute to the steroidogenic shift required for oocyte maturation (Chaube and Joy, ; Chourasia et al, ; Joy et al, ).…”

Section: Regulatory Mechanisms Of Protogynous Sex Changementioning

confidence: 99%

“…AVT, GnRH, and GnIH can be directly synthesized in the gonad, and are believed to modulate steroidogenesis and gonadal function (Habibi and Andreu‐Vieyra, ; Lubzens et al, ; McGuire and Bentley, ; Zhang et al, ; Ubuka et al, ; Joy and Chaube, ). In catfish, AVT stimulates E2 production during the vitellogenic phase but also promotes the steroidogenic shift from E2 to progesterone and maturation‐inducing hormone during oocyte maturation (Singh and Joy, ; Joy and Chaube, ). GnRH was also suggested to induce the steroidogenic shift necessary for follicle maturation, based on in vitro studies in catfish (Chaube et al, ).…”

Section: Regulatory Mechanisms Of Protogynous Sex Changementioning

confidence: 99%

Sexual plasticity: A fishy tale

Liu

Todd

Lokman

et al. 2016

Molecular Reproduction Devel

122

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SUMMARYTeleost fish exhibit remarkably diverse and plastic patterns of sexual development. One of the most fascinating modes of plasticity is functional sex change, which is widespread in marine fish including species of commercial importance; however, the regulatory mechanisms remain elusive. In this review, we explore such sexual plasticity in fish, using the bluehead wrasse (Thalassoma bifasciatum) as the primary model. Synthesizing current knowledge, we propose that cortisol and key neurochemicals modulate gonadotropin releasing hormone and luteinizing hormone signaling to promote socially controlled sex change in protogynous fish. Future largescale genomic analyses and systematic comparisons among species, combined with manipulation studies, will likely uncover the common and unique pathways governing this astonishing transformation. Revealing the molecular and neuroendocrine mechanisms underlying sex change in fish will greatly enhance our understanding of vertebrate sex determination and differentiation as well as phenotypic plasticity in response to environmental influences.

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Vasotocin – A new player in the control of oocyte maturation and ovulation in fish

Cited by 37 publications

References 72 publications

Molecular cloning and characterisation of an isotocin paralogue ([V8] isotocin) in catfishes (superorder Ostariophysi): Origin traced likely to the fish‐specific whole genome duplication

Molecular cloning and characterisation of an isotocin paralogue ([V8] isotocin) in catfishes (superorder Ostariophysi): Origin traced likely to the fish‐specific whole genome duplication

Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development

Sexual plasticity: A fishy tale

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