Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide.

Wei, Chao; Kim, Cheol H.; Miller, Virginia M.; Burnett, John C.

doi:10.1172/jci116800

Cited by 55 publications

(62 citation statements)

References 19 publications

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“…In rats VNP demonstrated natriuretic actions similar to those of ANP. 12 In canine veins VNP has more potent femoral, saphenous, and renal vein relaxing actions than CNP; these actions were not observed with ANP. 12 VNP also produced more potent femoral, saphenous, and renal arterial relaxation than either ANP or CNP.…”

Section: Discussionmentioning

confidence: 94%

“…We recently synthesized VNP, which is a chimera of CNP and ANP 12 and consists of the 22-amino acid ringed structure of CNP and the COOH terminus of ANP. In rats VNP demonstrated natriuretic actions similar to those of ANP.…”

Section: Discussionmentioning

confidence: 99%

“…11 Both CNP and ANP possess arterial vasorelaxing actions. 12 Furthermore, ANP is of cardiac origin and functions as a circulating hormone, whereas CNP is synthesized and released from endothelial cells, 1315 consistent with a paracrine role in the control of vascular tone.…”

Section: ^3 [Part 2]:903-907)mentioning

confidence: 99%

“…21 ' 23 We recently synthesized a new 27-amino acid peptide termed vasonatrin peptide (VNP). 12 VNP is a chimera of ANP and CNP and possesses the 22-amino acid ringed structure of CNP and the 5-amino acid COOH terminus of ANP. We demonstrated in vitro and in vivo that VNP possesses the venodilatory actions of CNP, the natriuretic actions of ANP, and unique peripheral arterial vasodilatory actions not associated with either.…”

mentioning

confidence: 99%

“…We demonstrated in vitro and in vivo that VNP possesses the venodilatory actions of CNP, the natriuretic actions of ANP, and unique peripheral arterial vasodilatory actions not associated with either. 12 This recent report suggested that VNP may mediate its unique augmented vasorelaxing actions via activation of both biological natriuretic peptide receptors (NPR-A and NPR-B).…”

mentioning

confidence: 99%

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Atrial natriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro.

et al. 1994

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The present study determined circulating concentrations of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) and also investigated the vasorelaxing action of ANP and CNP on isolated contracted aorta. We also defined the vasorelaxing action of a novel and newly synthesized 27-amino acid chimera of ANP and CNP termed vasonatrin peptide (VNP), which we compared with ANP and CNP in WKY rats and SHR. Plasma and urinary cyclic GMP and sodium excretion were also investigated. Plasma ANP was increased in SHR in contrast to no change in circulating CNP. Plasma and urinary cyclic GMP and sodium excretion were no different between WKY rats and SHR. In WKY rats maximal relaxations to VNP in aortic rings without endothelium were greater than those to ANP and CNP. In SHR aortic rings the potency of VNP relaxation was preserved, the actions of ANP were enhanced, and the actions of A trial natriuretic peptide (ANP) is a potent natri-/ \ uretic and vasoactive peptide that is produced -Z X . by atrial myocytes and is important in the control of cardiorenal homeostasis.13 ANP binds to a specific participate guanylyl cyclase receptor termed natriuretic peptide receptor-A (NPR-A), 4 which is expressed in endothelial and in renal epithelial cells 5 and mediates its biological actions. Previous reports have demonstrated that the vasoactive and natriuretic actions of ANP require its COOH terminus. 6 C-type natriuretic peptide (CNP) is a newly identified 22-amino acid peptide that like ANP has a 17-amino acid ring formed by a disulfide bond. Unlike ANP, CNP lacks the COOH terminus amino acid. CNP is genetically distinct from ANP 7 and functions biologically via a separate paniculate guanylyl cyclase receptor, natriuretic peptide receptor-B (NPR-B), 4 which is expressed in vascular smooth muscle cells and in the kidney. While ANP and CNP both decrease cardiac preload and arterial pressure, ANP-mediated decreases in arterial pressure are in part secondary to increases in sodium excretion, which is minimal with CNP. 910 In contrast, CNP is a potent endothelium-independent venodilator CNP were markedly impaired. In association with these vasorelaxing actions, these data suggest that (1) circulating CNP is not different in SHR and WKY rats, but the aortic relaxing action of CNP is markedly impaired in SHR; (2) endogenous plasma ANP is significantly increased in SHR without associated increases in plasma or urinary cyclic GMP; (3) there is an increase in aortic relaxation to exogenous ANP in SHR; and (4) VNP has a potent endothelium-independent aortic relaxing action in both WKY rats and SHR. These data suggest differential regulation of ANP and CNP and their vascular actions in SHR. These data also suggest that VNP could have an important therapeutic role in hypertension. and ANP is not.11 Both CNP and ANP possess arterial vasorelaxing actions.12 Furthermore, ANP is of cardiac origin and functions as a circulating hormone, whereas CNP is synthes...

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: ^3 [Part 2]:903-907)mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Atrial natriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro.

et al. 1994

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C‐type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines

et al. 2010

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Natriuretic peptides (NP) are a family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In this work we present computational structural analysis of the three human NP in solution, the synthesis and preliminary biological assays of a short fragment of CNP, I(14)GSM(17), together with one small mimetic, GGSM. Synthetic peptides IGSM, GGSM, and full length CNP were preliminary tested for their ability to influence cell growth of three human osteosarcoma cell lines. Synthetic peptides were shown to successfully mimic the biological activity of the full length natural peptide: their effects, although different upon the cell types used, are in accordance with the current literature, designating a possible role for CNP, and its derivatives, in skeletogenesis.

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Investigation of Cenderitide Controlled Release Platforms for Potential Local Treatment of Cardiovascular Pathology

Huang

Liu

et al. 2014

Journal of Pharmaceutical Sciences

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Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide.

Cited by 55 publications

References 19 publications

Atrial natriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro.

Atrial natriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro.

C‐type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines

Investigation of Cenderitide Controlled Release Platforms for Potential Local Treatment of Cardiovascular Pathology

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