Vasculogenic Erectile Dysfunction and Metabolic Syndrome

Abstract

Introduction Erectile dysfunction (ED), defined as the inability to achieve and/or maintain a penile erection sufficient for sexual intercourse, is a health problem affecting more than one-half of men between the age of 40 and 70 years. Aim The aim of the present study was to determine the potential factors affecting penile vascular flow and predictability of vascular flow in patients with ED. Methods Totally 163 male patients between 29 and 82 years of age who were admitted to our outpatient clinic with complaints of ED were included. After a detailed medical history was obtained, all patients were asked to complete the International Index of Erectile Function (IIEF) questionnaire. Blood samples were obtained for measurements of serum cholesterol, triglycerides, and fasting blood glucose (FBG), and the body mass index (BMI) was calculated. Main Outcome Measures Penile color Doppler ultrasonography (PDU) was performed to evaluate flow patterns, Mann–Whitney U-test and Spearman correlation analyses were used to assess the relationship of PDU findings with hypertension, obesity (BMI ≥ 25 kg/m2), FBG, and cholesterol levels measurements. Results The mean age, IIEF score, and BMI of the study population was 51.3 ± 12.1 years, 11.9 ± 6.1 and 28.5 ± 4.0 kg/m2, respectively. When the vascular pathologies detected with PDU and the presence of risk factors were compared, no significant correlation was determined between arterial insufficiency and metabolic syndrome (MS), whereas there was a significant correlation between veno-occlusive dysfunction and MS. Conclusion The prevalence of ED increases with advanced age and with the presence of a systemic disease. Basic evaluations may not always be sufficient for assessment of ED. In the presence of MS, the use of penile Doppler ultrasonography should be considered for the evaluation of penile vascular structures in ED patients.

Effect of Niacin on Erectile Function in Men Suffering Erectile Dysfunction and Dyslipidemia

“…While endothelial dysfunction and atherosclerosis are believed to be part of the main mechanisms for ED in patients with MS. Other mechanisms account for ED in MS include androgen deficiency, drugs, veno-occlusive mechanism, etc. [16]. Because dyslipidemia is one of the key risk factors for the development of endothelial dysfunction and atherosclerosis in MS patients, there is a close relationship between ED and dyslipidemia.…”

Reasons of Turkish Males with Erectile Dysfunction for Not Presenting to Urology Clinics

“…Keza ED'nin, hipertansiyon, diyabet, kalp ve damar hastalıkları gibi bazı komorbiditelerle yakın ilişkide olduğu ve bu hastalıklarla birlikte ED sıklığının arttığı bilinmektedir. 3,4,[24][25][26][27] Yaşlanma ile birlikte prevalansı artan ED, aynı zamanda yaşlı erkeklerde yaşam kalitesini düşüren seksüel disfonksiyonun en sık görülen formudur. 28,29 Ancak ED, ölümcül ve/veya günlük aktiviteyi kısıt-layan bir hastalık değildir.…”

Surgical niche for the treatment of erectile dysfunction

“…By far the most widely recognized vascular etiologies responsible for organic ED can be divided into AI, CVOD or mixed type, with CVOD representing the most common finding . It is of paramount importance that penile erection implicates arterial inflow, sinusoidal relaxation and corporoveno‐occlusive function.…”

“…2,3 By far the most widely recognized vascular etiologies responsible for organic ED can be divided into AI, CVOD or mixed type, with CVOD representing the most common finding. 4,5 It is of paramount importance that penile erection implicates arterial inflow, sinusoidal relaxation and corporoveno-occlusive function. In arteriogenic ED, corpora cavernosa show lower oxygen tension, 6 leading to a diminished volume of cavernosal smooth muscle and consequential CVOD.…”