Vasculitis leucocitoclástica asociada a la vacuna ARNm contra la COVID-19

A Systematic Review of Histopathologic Surveys on Mucocutaneous Biopsies in Patients Developed COVID-19 Vaccine-Related Dermatologic Manifestations

“…In multiple studies, histopathologic evaluation of vasculitis lesions showed leukocyte infiltration into the endothelia resulting in inflammation and swelling. 9–19 Subsequently, perivascular mixed lymphocytes, neutrophils, and occasional eosinophils plus marked debris and red blood cells (RBCs) extravasations were reported, which was consistent with leukocytoclastic vasculitis 10,11,13,14,16,18–27 ; these findings were also observed in 2 other cases: a figurate purpuric eruption 28 and a pigmented purpuric dermatosis. 29 Furthermore, immunofluorescence microscopy was performed on some samples, and deposition of C3, fibrin, fibrinogen, immunoglobulin M, and IgA were reported.…”