Vasculitis and bursitis on [18F]FDG-PET/CT following COVID-19 mRNA vaccine: post hoc ergo propter hoc?

Schierz, Jan-Henning; Merkel, Christine M.; Kittner, Thomas; Ali, Farzana

doi:10.1007/s00259-021-05553-3

Cited by 10 publications

(10 citation statements)

References 5 publications

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“…These data suggested that this large variability was related to the time elapsed between vaccination and examination and the criterion selected to define positivity. Although exceptional cases of diseases occurred or worsened apparently after COVID-19 vaccination have been described in PET/ CT literature [19][20][21][22][23][24][25][26][27][28][29][30][31][32], none of the included studies reported findings suggestive for systemic reaction. The only exception was the study of Siripongsatian et al [18] who specifically evaluated a small series of patients who experienced neurological symptoms after COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 98%

COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

Kirienko

Biroli

Pini

et al. 2022

Clin Transl Imaging

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Introduction The present paper aims to systematically review the literature on COVID-19 vaccine-related findings in patients undergoing PET/CT. Methods The search algorithms included the following combination of terms: “PET” OR “positron emission tomography” AND “COVID”; “PET” OR “positron emission tomography” AND “COVID” AND “vaccination”; “PET” OR “positron emission tomography” AND “COVID”, AND “autoimmune”. Results We selected 17 articles which were assessed for quality and included in the systematic analysis. The most frequent vaccine-related signs on PET/CT were the deltoid [ 18 F]FDG uptake and axillary hypermetabolic lymph nodes, which were described in 8–71% and 7–90% of the patients, respectively. Similarly, frequency of these findings using other tracers than [ 18 F]FDG was greatly variable. This large variability was related to the variability in time elapsed between vaccination and PET/CT, and the criteria used to define positivity. In addition, vaccine-related findings were detected more frequently in young and immunocompetent patients than in elderly and immunocompromised ones. Discussion Therefore, awareness on vaccination status (timing, patient characteristics, and concurrent therapies) and knowledge on patterns of radiopharmaceutical uptake are necessary to properly interpret PET/CT findings.

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Section: Discussionmentioning

confidence: 98%

COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

Kirienko

Biroli

Pini

et al. 2022

Clin Transl Imaging

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“…After seven weeks of illness, she was diagnosed with GCA on a positron emission tomography (PET) scan with a CRP of 98 mg/L [ 10 ]. Other mRNA vaccine-related case reports include a 79-year-old man who developed GCA two days after his second dose of the vaccine [ 11 ], an 82-year-old man who developed bilateral GCA with skin necrosis 10 days after his second dose of vaccine [ 12 ], a new-onset GCA in an 83-year-old woman happened 24 hours after the first dose of the vaccine [ 13 ], a 63-year-old woman who developed GCA the day after the first dose of the vaccine [ 14 ], and a 78-year-old female diagnosed with large vessel vasculitis post vaccine with symptoms that started after the first shot and worsened after the second shot [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Giant Cell Arteritis With a Normal Erythrocyte Sedimentation Rate (ESR) Post ChAdOx1 nCoV-19 Vaccination

Xia¹,

Edwards²,

Omidvar³

2022

Cureus

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“…Two reports of de novo vasculitis following mRNA vaccination describe an old healthy woman and a younger man with treated arterial hypertension [ 46 ]. Large Vessel Vasculitis (LVV) was reported after mRNA-1273 vaccination in an old woman that complained about cephalgia, cervicalgia, ostealgia and pain in multiple large joints and muscles that started 2–3 weeks after the first and worsened after the second dose; [18F]FDG-PET/CT demonstrated increased tracer uptakes in the large arteries of the legs [ 47 ].…”

Section: Mrna Vaccination Against Covid-19 and Diagnosis Of Spontaneo...mentioning

confidence: 99%

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

Mouliou

Dardiotis

2022

Diagnostics

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The novel mRNA vaccinations against COVID-19 are gaining worldwide attention for their efficacy, as well as the diagnosis of some post-vaccination-reported adverse reactions. In this state-of-the-art review article, we present the current evidence regarding mainly the diagnosis of spontaneous allergic reactions, the skin occurrences, the vascular, blood, endocrine and heart events, the respiratory reports, the gastrointestinal, hepatic and kidney events, the reproductive and pregnancy issues and the muscle events, as well as the ear, eye, neurologic and psychiatric events following mRNA vaccination against COVID-19. We further present some evidence regarding the mRNA strategies and we discuss our expert opinion on the knowns and the unknowns towards the topic.

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Vasculitis and bursitis on [18F]FDG-PET/CT following COVID-19 mRNA vaccine: post hoc ergo propter hoc?

Cited by 10 publications

References 5 publications

COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

A Case of Giant Cell Arteritis With a Normal Erythrocyte Sedimentation Rate (ESR) Post ChAdOx1 nCoV-19 Vaccination

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

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