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Cited by 23 publications
(14 citation statements)
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References 26 publications
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“…Assuming that the process of angiogenesis (sprouting of vital resident ECs) is largely abrogated upon local high-dose RT (15–20 Gy), tumors rely on infiltration of circulating endothelial and other progenitor cells for revascularization and regrowth. This secondary “backup” pathway termed vasculogenesis represents a novel strategy to enhance local tumor control by RT (72, 73). Notably, even though endothelial progenitor cells (EPCs) are recognized for homing to ischemic areas where they contribute to neovascularization (74, 75), extensive research efforts has lead to the conclusion that bone-marrow-derived EPCs are contributing only marginally to (re)growth of irradiated tumors (71, 76).…”
Section: Endothelial Cells and The Different Rt-regimensmentioning
confidence: 99%
“…Assuming that the process of angiogenesis (sprouting of vital resident ECs) is largely abrogated upon local high-dose RT (15–20 Gy), tumors rely on infiltration of circulating endothelial and other progenitor cells for revascularization and regrowth. This secondary “backup” pathway termed vasculogenesis represents a novel strategy to enhance local tumor control by RT (72, 73). Notably, even though endothelial progenitor cells (EPCs) are recognized for homing to ischemic areas where they contribute to neovascularization (74, 75), extensive research efforts has lead to the conclusion that bone-marrow-derived EPCs are contributing only marginally to (re)growth of irradiated tumors (71, 76).…”
Section: Endothelial Cells and The Different Rt-regimensmentioning
confidence: 99%
“…Vascular damage after irradiation is a potentially important aspect of normal tissue and tumor responses that is compounded by a failure of angiogenesis, as can be demonstrated by the “tumor bed effect”, where tumor growth in an irradiated site is slower than normal (108). In fact, hypoxia may be a general switch within any inflammatory site to drive factors like hypoxia inducing factor 1 (HIF-1) to reprogram a pro-oxidant, pro-inflammatory microenvironment to one supporting angiogenesis and wound healing through HIF-dependent cytokines, such as VEGF (Fig.…”
Section: A Brief History Of Cytokines and Their Characteristicsmentioning
confidence: 99%
“…Chemotaxis of bone marrow-derived cells to areas of irradiation damage is already known in oncological research and was the basis for a potential therapeutic benefit of stem cell therapy after irradiation damage. 31,32 Chemotaxis in this context is mediated by hypoxia-related overexpression of HIF1 α and stromal-derived factor (SDF1) and was previously demonstrated both in hypoxic tumor and non-tumor tissues. 33,34 We could not directly prove a state of aggravated hypoxia in the irradiated constructs at the studied time points where the vascularity and apoptosis were not significantly different between both groups.…”
Section: Discussionmentioning
confidence: 93%