Vascularization

Duvernoy, Henri M.; Cattin, F.; Risold, Pierre‐Yves

doi:10.1007/978-3-642-33603-4_5

Cited by 41 publications

(67 citation statements)

References 35 publications

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“…The density of AT8-ir astrocytes, but not AT8-ir neurons, was markedly increased in the MB in NIA/AA stage B2. The thorn-shaped morphology of the p-MAPT immunoreactive astrocytes was consistent with aging-related tau astrogliopathy (ARTAG) [9]. In NIA/AA stage B3, there was a significant increase in AT8-ir neurons as well as admixed AT8-ir astrocytes in the MB (Fig.…”

Section: Resultsmentioning

confidence: 60%

“…To our knowledge, p-MAPT neuropathology in the fornix in the spectrum of AD neuropathologic changes has not been reported. The fornix is a major tract of efferent fibers from the hippocampal formation (reviewed in Duvernoy et al [9]). Efferent fibers of the postcommissural fornix innervate the mammillary body and anterior thalamic nucleus in the regulation of memory.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Plowey

Ziskin

2016

acta neuropathol commun

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Whereas early Alzheimer disease (AD) neuropathology and mild cognitive impairment are relatively common in aging, accurate prediction of patients that will progress to dementia requires new biomarkers. Recently, substantial work has focused on phospho-tau/MAPT (p-MAPT) neuropathology since its regional propagation correlates with the degree of cognitive impairment in AD. Recent diffusion tensor imaging studies in AD suggest that increased diffusion in the fornix secondary to p-MAPT-related axonal injury could serve as a predictive biomarker of the risk of disease progression. However, our knowledge of p-MAPT neuropathology in the fornix is limited. To address this gap in knowledge, we examined p-MAPT neuropathology in the fornix and basal forebrain nuclei via AT8 immunohistochemistry in 39 brain autopsies spanning the spectrum of AD neuropathologic changes. We found that the fornix and its precommissural efferent target nuclei (septum and nucleus accumbens) demonstrated neuronal and thread-like p-MAPT neuropathology only in National Institute on Aging/Alzheimer Association (NIA/AA) stages B2 and B3 of neurofibrillary degeneration, consistent with involvement after (and propagation from) the hippocampal formation. Interestingly, although tau astrogliopathy was frequently observed in the mammillary bodies in stage B2, neuronal tauopathy was not observed in the postcommissural targets (mammillary bodies and anterior thalamic nucleus) until stage B3. Tauopathy in the nucleus basalis of Meynert was strongly correlated with p-MAPT-positive axons in the fornix, suggesting that projections to the hippocampus also likely contribute to fornix tauopathy. Our cross-sectional autopsy findings indicate that the fornix is involved by p-MAPT neuropathology secondary to hippocampal involvement by AD neuropathology. Furthermore, our findings are compatible with the goal of in vivo detection of p-MAPT-related axonal pathology in the fornix in AD as a possible biomarker of p-MAPT progression from the hippocampal formation and underscore a need for additional clinical-radiologic-pathologic correlation studies.

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Section: Resultsmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Plowey

Ziskin

2016

acta neuropathol commun

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“…These regions, though adjacent, differ in vascularization, cell population, and connectivity, which could explain the divergent responses to nPM. The stratum oriens is more densely vascularized than the stratum radiatum (Duvernoy et al, 2013, Grivas et al, 2003) and has different connectivity. For example, the entorhinal cortex projections to the stratum oriens are denser than to the stratum radiatum, while CA3 sends projections to both strata, but with more projections to the radiatum, via the Schaffer collaterals (Figure 2E).…”

Section: Discussionmentioning

confidence: 99%

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

Woodward

Pakbin

Saffari

et al. 2017

Neurobiology of Aging

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Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5 μm diameter (PM2.5). Rodents exposed to TRAP have shown microglial activation and neuronal atrophy. We further investigated age differences of TRAP exposure, with focus on hippocampus for neuritic atrophy, white matter degeneration, and microglial activation. Young and middle-aged mice (3 and 18 month female C57BL/6J) were exposed to nanoscale-PM (nPM, <0.2 μm diameter). Young mice showed selective changes in the hippocampal CA1 region, with neurite atrophy (−25%), decreased MBP (−50%), and increased Iba1 (+50%), with dentate gyrus relatively unaffected. Exposure to nPM of young mice decreased GluA1 protein (−40%) and increased TNFa mRNA (10×). Older controls had age changes approximating nPM effects on young, with no response to nPM, suggesting an age ceiling effect. The CA1 selective vulnerability in young mice parallels CA1 vulnerability in Alzheimer’s disease. We propose that TRAP associated human cognitive and white matter changes involve hippocampal responses to nPM that begin at younger ages.

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“…Mean aCBV values were recorded in the left and right hippocampus at each TI. The middle hippocampal artery, a branch of the posterior cerebral artery, partial volumes with the hippocampal ROI (27). To measure parenchymal aCBV and avoid macrovascular aCBV, voxels with aCBV > 0.05 ml/ml were excluded from the analysis.…”

Section: Methodsmentioning

confidence: 99%

Inflow‐vascular space occupancy (iVASO) reproducibility in the hippocampus and cortex at different blood water nulling times

Rane

Talati

Donahue

et al. 2015

Magnetic Resonance in Med

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Purpose Inflow-vascular space occupancy (iVASO) measures arterial cerebral blood volume (aCBV) using accurate blood water nulling (TI) when arterial blood reaches the capillary, i.e., at the arterial arrival time. This work assessed the reproducibility of iVASO measurements in the hippocampus and cortex at multiple TIs. Methods The iVASO approach was implemented at multiple TIs in 10 healthy volunteers at 3T. aCBV values were measured at each TI in the left and right hippocampus, and the cortex. Reproducibility of aCBV measurements within scans (same day) and across sessions (different days) was assessed using the intra-class correlation coefficient (ICC). Results Overall hippocampal aCBV was significantly higher than cortical aCBV, likely due to higher gray matter volume. Hippocampal ICC values were high at short TIs (≤914 ms; intra-scan values = 0.80–0.96, inter-scan values = 0.61–0.91). Cortically, high ICC values were observed at intermediate TIs of 914 (intra: 0.93, inter: 0.87) and 1034 ms (intra: 0.96, inter: 0.86). The ICC values were comparable to established contrast-based CBV measures. Conclusion iVASO measurements are reproducible within and across sessions. TIs for iVASO measurements should be chosen carefully, taking into account heterogeneous arterial arrival times in different brain regions.

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Vascularization

Cited by 41 publications

References 35 publications

Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

Inflow‐vascular space occupancy (iVASO) reproducibility in the hippocampus and cortex at different blood water nulling times

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