Vascular solitary fibrous tumor with “floret” cells or giant cell angiofibroma? a lingual example highlighting the overlapping characteristics of these entities and positive immunoreaction for estrogen and progesterone receptors

Piperi, Evangelia; Rohrer, Michael D.; Pambuccian, Stefan E.; Koutlas, Ioannis G.

doi:10.1016/j.tripleo.2008.12.046

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…Immunohistochemical stains were positive for vimentin, CD34, acid mucopolysaccharides, and focally for CD68 (and factor XIIIa), but were negative for S100 and SMA. The differential diagnoses comprised of conjunctival (cellular) myxoma, 5 neurothekeoma, 3 subconjunctival herniated orbital fat, 7 fat-free spindle cell lipoma, 2 pseudotumor, neurofibroma, 8 dendrocytoma, 13 nevus with neuronal degeneration, 14 solitary fibrous tumor, 11 fibrous histiocytoma, 1, 6, 9 nodular fasciitis, 14 hemangiopericytoma, 4 giant cell angiofibroma, 10 and rhabdomyosarcoma. 12 Our benign conjunctival lesions were differentiated from these entities by cytologic and immunohistochemical features.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Stromal Tumor: Report of 4 Cases

2012

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Purpose To describe the clinical, histopathologic, immunohistochemical, and ultrastructural features of a case series of benign stromal tumors in the bulbar conjunctiva. Design Observational case series. Participants Four patients with a conjunctival lesion that were classified histologically as low grade stromal tumors consisting of spindle-shaped cells with occasional pseudonuclear inclusion and multinucleated cells in a partly myxoid matrix. Methods Four cases of low grade conjunctival stromal tumors were retrospectively identified in an ophthalmic pathology laboratory database. Patients’ records were analyzed for demographic data, clinical appearance and the post-operative course. Formalin-fixed paraffin-embedded specimens were routinely processed and stained with hematoxylin and eosin (H&E) and periodic acid Schiff (PAS). Immunohistochemical stains for vimentin, S100, CD34, SMA (smooth muscle actin), CD68, and factor XIIIa were performed. Transmission electron microscopy (TEM) was performed on three of the cases. Main Outcome Measures Histopathologic evaluation (including immunostains and TEM) and clinical correlation. Results All four tumors occurred in the bulbar conjunctiva of patients between 41 to 53 years of age. None of the patients developed recurrence after excisional biopsy. Histologically, all tumors exhibited spindle-shaped cells with pseudonuclear inclusions and occasional multinuclear cells. Mitotic figures were not observed. The stroma appeared myxoid to collagenous. Immunohistochemical stains were positive for CD34, vimentin, and focally for CD68, but were negative for S100 and SMA. Conclusions We propose to classify these benign lesions which share distinct histopathologic features as “conjunctival stromal tumor (COST)”. A reactive/inflammatory component needs to be considered in the pathogenesis of this lesion.

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Section: Discussionmentioning

confidence: 99%

Conjunctival Stromal Tumor: Report of 4 Cases

2012

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“…The overlapping features include their common occurrence in middle-aged adults with an equal gender distribution, their well-circumscribed and variably unencapsulated "patternless" spindle cell lesions with variably collagenized stroma, and their immunopositivity for CD34 and CD99. Some cases of SFTs have angiectoid spaces and multinucleated giant cells in the stroma 9,10. In this report, we present a lacrimal gland SFT with floret-like giant cells that are characteristic of GCAF.…”

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confidence: 70%

A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case Study

Son

Yoo

et al. 2013

Korean J Pathol

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Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examination showed a proliferation of relatively uniform spindle cells with a patternless or focally storiform pattern. Dilated vessels were prominent, but angiectoid spaces lined with giant cells were absent. Floret-type giant cells were mostly scattered in the periphery. The tumor was immunoreactive for CD34 and CD99, but negative for smooth muscle actin and S-100 protein. This is the first Korean case of SFT of the lacrimal gland with overlapping features of GCAF, suggesting a close relationship between the two entities.

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“…Giant cells and pseudovascular spaces are infrequent and serve to distinguish this tumor type from GCA. Both are immunoreactive for CD34 and CD99 [16,25,26]. …”

Section: Discussionmentioning

confidence: 99%

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

Zhang

Liu

et al. 2014

World J Surg Onc

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PurposeTo present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA).Case presentationIn this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease.After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA.ConclusionGCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate.

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Vascular solitary fibrous tumor with “floret” cells or giant cell angiofibroma? a lingual example highlighting the overlapping characteristics of these entities and positive immunoreaction for estrogen and progesterone receptors

Cited by 12 publications

References 21 publications

Conjunctival Stromal Tumor: Report of 4 Cases

Conjunctival Stromal Tumor: Report of 4 Cases

A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case Study

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

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