Vascular Involvement in the Prognosis of Primary Cutaneous Melanoma

Kashani‐Sabet, Mohammed; Sagebiel, Richard W.; Ferreira, Carlos; Nosrati, Mehdi; Miller, James R.

doi:10.1001/archderm.137.9.1169

Cited by 110 publications

(68 citation statements)

References 22 publications

(18 reference statements)

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“…Angiolymphatic invasion has been reported as an adverse indicator for both SLN positivity and overall survival in patients with melanoma. 7,8,25,26 Body site location also was a significant predictor of SLN positivity in our model. Location of the primary melanoma on the trunk or lower extremities doubled the odds of SLN positivity (OR, 1.92) compared with location on the head/neck or upper extremities.…”

Section: Discussionmentioning

confidence: 69%

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Paek

Griffith

Johnson

et al. 2006

Cancer

175

106

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Epithelial growth, branching, and canalization are important morphogenetic events of the rodent ventral prostate (VP) that take place during the first postnatal week. In this study, we evaluated the effect of knocking out MMP‐2 (MMP‐2−/−), by examining developmental and structural aspects of the VP in MMP‐2−/− mice. Neonate (day 6) MMP‐2−/− mice showed fewer epithelial tips, a lower epithelial cell proliferation rate, and also reticulin fiber accumulation. The VP of adult MMP‐2−/− mice showed lower relative weight, smaller epithelial and smooth‐muscle cell volume, and a larger amount of thicker reticulin fibers. No differences in cell proliferation or apoptotic index were noted between adult MMP‐2−/− and wild‐type mice. MMP‐9 was found in the adult MMP‐2−/−, but not in the wild‐type. In conclusion, MMP‐2 function is essential for the epithelial morphogenesis of the mouse VP, and expression of MMP‐9 is not sufficient for acquisition of the normal adult histology. Developmental Dynamics 239:2386–2392, 2010. © 2010 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 69%

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Paek

Griffith

Johnson

et al. 2006

Cancer

175

106

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“…A previous study revealed that vascular invasion was an independent predictive factor of metastasis and survival in melanoma (Kashani-Sabet et al, 2001). On a multivariate analysis, vascular invasion was the second most important factor after the tumor thickness (Kashani-Sabet et al, 2001).…”

Section: Discussionmentioning

confidence: 86%

“…On a multivariate analysis, vascular invasion was the second most important factor after the tumor thickness (Kashani-Sabet et al, 2001). The prognosis of malignant melanoma depends on mostly clinical stage at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 98%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), ≥6/mm 2 mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.

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“…Vascular invasion is associated with poorer prognosis and should be mentioned in the pathology report [101]. Micrometastases and in-transit metastases found at primary excision are taken into account in the TMN classification (N status).…”

Section: Rosementioning

confidence: 99%