Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6

Zhao, Rui; Liu, Xiangqun; Wu, Xiaopeng; Liu, Yanfeng; Zhang, Zhaoyang; Yang, Guangli; Guo, Shu; Ni, Jun; Wang, Jiayong; Xu, Kesen

doi:10.1016/j.canlet.2009.06.006

Cited by 45 publications

(35 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results indicate that CXCL1-induced cell migration is VEGF dependent. Zhao et al found that VEGF promotes GC invasiveness via integrin α5β6 [33]. In bladder cancer, effects of VEGF on cell invasion were also reported [34].…”

Section: Discussionmentioning

confidence: 94%

CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer

Wei¹,

Xia

et al. 2015

Cancer Letters

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer

Wei¹,

Xia

et al. 2015

Cancer Letters

View full text Add to dashboard Cite

“…Two growth factors of particular importance in wound healing, VEGF and TGFb, 108 have each been functionally linked to integrins that are expressed in wound epidermis. For instance, a 6 b 4 was shown to enhance VEGF translation in carcinoma cells, 109 and VEGF expression can upregulate a v b 6 in some carcinoma cells, 110 raising the intriguing possibility of dynamic integrin-growth factor feedback loops that might extend to wound keratinocytes. Additionally, a v b 6 -mediated activation of latent TGFb (see previous section) might stimulate the expression of a 5 b 1 and a v b 5 in keratinocytes.…”

Section: Functions Of Wound Epidermis That Are Regulated By Integrinsmentioning

confidence: 99%

Integrin Regulation of Epidermal Functions in Wounds

Longmate

DiPersio

2014

Advances in Wound Care

View full text Add to dashboard Cite

“…Vascular endothelial growth factor (VEGF) up-regulates the αvβ6 integrin in gastric carcinoma cells and ERK to induce invasiveness of the cancer cells [47]. It is reported in vivo that VEGF and α6 integrin support the adhesion of mammary cancer cell to vascular endothelium [48].…”

Section: Integrin αVβ6 and αVβ5mentioning

confidence: 99%

Important role of integrins in the cancer biology

Rathinam

Alahari

2010

Cancer Metastasis Rev

201

167

View full text Add to dashboard Cite

Adhesion of breast cancer cells is supported by various integrins. Cell adhesion is critical for maintenance of both three-dimensional and normal function of these tissues. Several integrins have been shown to have higher expression levels in metastatic cancers and have been implicated in degrading basement membrane by interacting with proteolytic enzymes. This suggests that a group of integrins plays an important role in migration and invasion through the remodeling of the extracellular matrix. In this review, we highlight recent advances in our understanding of how integrins regulate breast cancer through modulation of the actin cytoskeleton and the mechanisms that regulate this process. Also, we highlight the importance of integrin-binding proteins in cell migration and mechanisms that operate in invasive cells, during breast cancer progression.

show abstract

Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6

Cited by 45 publications

References 27 publications

CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer

CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer

Integrin Regulation of Epidermal Functions in Wounds

Important role of integrins in the cancer biology

Contact Info

Product

Resources

About