volume 28, issue 3, P324-330 2007
DOI: 10.2500/aap.2007.28.2999
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Abstract: Airway remodeling may lead to increased secretion of TGF-beta. TGF-beta is known to activate fibroblasts and to stimulate the secretion of vascular endothelial growth factor (VEGF). Soluble and cell-associated VEGF have been identified in subjects with chronic severe asthma. Dermatophagoides sp. has been shown to contribute to the pathogenesis of asthma. The aim of this study was to determine if the Dermatophagoides sp. extract can stimulate confluent A549 (cA549) to express soluble or cell-associated VEGF and…

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