2003
DOI: 10.1080/09629350310001619726
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Abstract: We investigated the serum concentration of vascular endothelial growth factor (VEGF) and its two soluble receptors, sVEGFR-1 and sVEGFR-2, in a group of 60 patients with systemic lupus erythematosus (SLE), and 20 healthy controls, using an enzyme-linked immunosorbent assay. We examined a possible association between serum levels of these proteins and certain clinical and laboratory parameters as well as SLE activity. VEGF, sVEGFR-1 and sVEGFR-2 were detectable in all patients with SLE and in all normal individ… Show more

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Cited by 57 publications
(50 citation statements)
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“…Data about the relationship between SLE and proangiogenic and antiangiogenic factors during pregnancy is limited and not uniform. [31][32][33] In a retrospective case-control study concerning 52 SLE pregnancies (blood sampled between 22 and 32 weeks of gestation), the serum concentration of sFlt-1 was significantly higher in the SLE pregnancies with (superimposed) preeclampsia (n=18) than in those without preeclampsia (1768 versus 1177 pg/mL), whereas the serum PlGF concentration between the 2 groups did not differ. 33 Further prospective studies with repeated determination of the sFlt-1/PlGF ratio are required to clarify whether SLE during pregnancy, either active or not, has influence on the sFlt-1/PlGF ratio and whether the rise in this ratio, characteristic for early onset preeclampsia, is still fully present.…”
Section: Factors Influencing the Sflt-1/plgf Ratiomentioning
confidence: 99%
“…Data about the relationship between SLE and proangiogenic and antiangiogenic factors during pregnancy is limited and not uniform. [31][32][33] In a retrospective case-control study concerning 52 SLE pregnancies (blood sampled between 22 and 32 weeks of gestation), the serum concentration of sFlt-1 was significantly higher in the SLE pregnancies with (superimposed) preeclampsia (n=18) than in those without preeclampsia (1768 versus 1177 pg/mL), whereas the serum PlGF concentration between the 2 groups did not differ. 33 Further prospective studies with repeated determination of the sFlt-1/PlGF ratio are required to clarify whether SLE during pregnancy, either active or not, has influence on the sFlt-1/PlGF ratio and whether the rise in this ratio, characteristic for early onset preeclampsia, is still fully present.…”
Section: Factors Influencing the Sflt-1/plgf Ratiomentioning
confidence: 99%
“…The recombinant form of this protein has anti-angiogenic activity [102]. Plasma sVEGFR-2 concentration is lower in patients with systemic lupus erythematosus (SLE) disease [103] and higher in those with acute leukemia, compared to healthy controls [104]. There is a paucity of information on plasma sVEGFR-2 concentrations in preeclampsia and SGA [105].…”
Section: Introductionmentioning
confidence: 99%
“…3,23,24 Increased levels of VEGF and VEGFR-1 in plasma were detected in patients with active SLE as compared to the levels in patients with inactive disease and in controls. 25 Moreover, VEGF was overexpressed in the skin in systemic sclerosis (SSc) and its increased levels correlated with the severity of nailfold capillary loss in SSc. 5 Considerable amounts of VEGF in both glandular epithelia and inflammatory cells of inflamed glands in SS patients as compared with those from HS were observed.…”
Section: Discussionmentioning
confidence: 99%