Varieties of lithium benefit

Depression and mysticism: Case report and literature review.

“…A further framework that informed the psychiatrist’s therapeutic approach with Barbra was that of spiritual emergency as laid out by Grof and Grof (1990). Barbra’s mystical experience conformed to those authors’ description of “peak experiences” or “unitive consciousness” (p. 74).…”

Depression and mysticism: Case report and literature review.

“…A further framework that informed the psychiatrist’s therapeutic approach with Barbra was that of spiritual emergency as laid out by Grof and Grof (1990). Barbra’s mystical experience conformed to those authors’ description of “peak experiences” or “unitive consciousness” (p. 74).…”

Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research

“…Further, a certain proportion of patients will require combination stabilizing treatment given medical comorbidities or to gain the non-specific benefits of lithium. That is, lithium has a variety of benefits that go beyond the specific stabilizing effect and use should therefore not be entirely curtailed to stabilization in patients with a lithium responsive bipolar profile (Grof and Grof 1990;Grof and Muller-Oerlinghausen 2009). Finally, the prediction of lithium response based on clinical profiles outlined here has not as yet been tested in a large randomized controlled trial.…”

Pattern of Response to Divalproex, Lithium, or Placebo in Four Naturalistic Subtypes of Mania

“…The pattern of symptom change associated with antimanic response did not differ in patients who responded to placebo, divalproex, or lithium, suggesting that the aspects of behavior measured in manic rating scales used were nonspecific relative to the mechanisms of action of antimanic treatments, placebo, or spontaneous remission (Grof and Grof 1990;Johnstone 1988;Schaff et al 1993). Alternatively, the endpoint time of measuring symptom change could have missed earlier indications of more specifically drug-linked behavior changes.…”

Depression and mysticism: Case report and literature review.

“…A further framework that informed the psychiatrist’s therapeutic approach with Barbra was that of spiritual emergency as laid out by Grof and Grof (1990). Barbra’s mystical experience conformed to those authors’ description of “peak experiences” or “unitive consciousness” (p. 74).…”

Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research

“…Further, a certain proportion of patients will require combination stabilizing treatment given medical comorbidities or to gain the non-specific benefits of lithium. That is, lithium has a variety of benefits that go beyond the specific stabilizing effect and use should therefore not be entirely curtailed to stabilization in patients with a lithium responsive bipolar profile (Grof and Grof 1990;Grof and Muller-Oerlinghausen 2009). Finally, the prediction of lithium response based on clinical profiles outlined here has not as yet been tested in a large randomized controlled trial.…”

Pattern of Response to Divalproex, Lithium, or Placebo in Four Naturalistic Subtypes of Mania

“…The pattern of symptom change associated with antimanic response did not differ in patients who responded to placebo, divalproex, or lithium, suggesting that the aspects of behavior measured in manic rating scales used were nonspecific relative to the mechanisms of action of antimanic treatments, placebo, or spontaneous remission (Grof and Grof 1990;Johnstone 1988;Schaff et al 1993). Alternatively, the endpoint time of measuring symptom change could have missed earlier indications of more specifically drug-linked behavior changes.…”

Depression and mysticism: Case report and literature review.

“…A further framework that informed the psychiatrist’s therapeutic approach with Barbra was that of spiritual emergency as laid out by Grof and Grof (1990). Barbra’s mystical experience conformed to those authors’ description of “peak experiences” or “unitive consciousness” (p. 74).…”

Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research

“…Further, a certain proportion of patients will require combination stabilizing treatment given medical comorbidities or to gain the non-specific benefits of lithium. That is, lithium has a variety of benefits that go beyond the specific stabilizing effect and use should therefore not be entirely curtailed to stabilization in patients with a lithium responsive bipolar profile (Grof and Grof 1990;Grof and Muller-Oerlinghausen 2009). Finally, the prediction of lithium response based on clinical profiles outlined here has not as yet been tested in a large randomized controlled trial.…”

Pattern of Response to Divalproex, Lithium, or Placebo in Four Naturalistic Subtypes of Mania

“…The pattern of symptom change associated with antimanic response did not differ in patients who responded to placebo, divalproex, or lithium, suggesting that the aspects of behavior measured in manic rating scales used were nonspecific relative to the mechanisms of action of antimanic treatments, placebo, or spontaneous remission (Grof and Grof 1990;Johnstone 1988;Schaff et al 1993). Alternatively, the endpoint time of measuring symptom change could have missed earlier indications of more specifically drug-linked behavior changes.…”