Variations of the liver standardized uptake value in relation to background blood metabolism

Liu, Guobing; Hu, Yan; Zhao, Yanzhao; Yu, Haojun; Hu, Pengcheng; Shi, Hongcheng

doi:10.1097/md.0000000000010699

Cited by 12 publications

(9 citation statements)

References 24 publications

(26 reference statements)

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“…In contrast to the previous studies, we also investigated other parameters of 18 F-FDG uptake, the TLR and TMR. TLR was calculated using a reference spherical VOI in the liver (3 cm in diameter) because hepatic 18 F-FDG uptake has been shown to correlate with circulating 18F-FDG levels [54], and the liver's size makes it easy to assign VOIs. TLR appears to be less influenced by body composition, image reconstruction methods or PET equipment, as compared to SUVmax [54][55][56][57][58].…”

Section: Discussionmentioning

confidence: 99%

Correlation between semiquantitative and volumetric 18F-FDG PET/computed tomography parameters and Ki-67 expression in breast cancer

Mohamadien

Sayed

2021

Nuclear Medicine Communications

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Objectives To evaluate the relationship between semiquantitative and volumetric parameters on 18F-FDG PET/computed tomography (CT), including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), tumor to liver ratio (TLR) and tumor to mediastinum ratio (TMR) with the level of Ki-67 expression in breast cancer. Patient and methods We retrospectively reviewed 105 female patients with newly diagnosed breast cancer who underwent baseline 18F-FDG PET/CT and had immunohistochemical staining to determine the level of Ki-67 expression. The following PET parameters were measured (SUVmax, SUVmean, MTV, TLG, TLR and TMR) and correlated with level of Ki-67 expression. Results Significant moderate positive correlations were found between the PET parameters (primary SUVmax, SUVmean, TLG, TLR and TMR) and level of Ki-67 expression. The primary SUVmax had the highest correlation coefficient (r = 0.461) followed by TMR (r = 0.455) and P value of <0.001 for both. In ROC analysis, primary SUVmax had the largest area under the curve (0.806, P = 0.0001), with sensitivity of 76.5 % and specificity of 75% for prediction of high Ki-67 level. In univariate analysis, all PET parameters, patient age, tumor grade, molecular subtype, estrogen receptor and progesterone receptor status were significantly associated with Ki-67 level. In multivariate regression analysis, only tumor grade [odds ratio (OR) = 20.460, 95% confidence interval (CI): 11.360–29.559, P = <0.0001], molecular subtype (OR = −21.894, 95% CI: −37.921 to −5.866, P = 0.008), SUVmax (OR = 2.299, 95% CI: 0.703–3.895, P = 0.005) and TLR (OR = −4.908, 95% CI: −9.476 to −0.340, P = 0.035) were found to be the strongest independent predictor factors for the level of Ki-67 expression and hence proliferative activity of malignant cells in breast cancer. Conclusion The semiquantitative parameters and volumetric 18F-FDG PET/CT parameter, that is, TLG correlated well with proliferation marker Ki-67 in breast cancer. 18F-FDG PET/CT imaging can be used as a useful noninvasive diagnostic tool in imaging cellular proliferation and hence may substitute for in vitro testing of molecular markers in the diagnoses and staging of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Correlation between semiquantitative and volumetric 18F-FDG PET/computed tomography parameters and Ki-67 expression in breast cancer

Mohamadien

Sayed

2021

Nuclear Medicine Communications

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“…The consumption of NO and the lack of its vasodilatory effect play an important role in cerebral vasospasm. After SAH occurs, the NO content decreased, and the responsiveness of vascular smooth muscle to NO may decrease, leading to the inability to maintain normal diastolic function and causing vasospasm [ 14 ]. In this study, the level of NO in Figure 8d basically recovered to the level of 6 hours after 72 hours.…”

Section: Discussionmentioning

confidence: 99%

Analysis of role of rat cerebral pericytes in cerebral vasospasm after subarachnoid hemorrhage and molecular mechanism of neurovascular injury

et al. 2021

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To investigate mechanism of pericytes in the early stage of subarachnoid haemorrhage (SAH) and its associated microvascular spasm and neurovascular injury, 100 healthy 8-week-old Sprague-Dawley male rats were taken as subjects and divided into four groups: group A (sham operation, control group), group B (SAH operation group), group C (SAH operation group treated with scutellarin), and group D (SAH operation group treated with L-nitro-arginine). 72 hours after the operation, the rats were conducted assessment of neurological impairment, observation of microangiography, detection of blood-brain barrier permeability, observation of skull base haemorrhage, identification of pericyte culture, and measurement of blood nitric oxide. The results showed that neurological impairment score, degree of micro-vasoconstriction, and BBB permeability of group C were significantly better than those of group B and D (P<0.05), there was no significant difference between group C and group A (P>0.05). There were significantly fewer blood clots in the brain of group C, and the order of expression levels of α-smooth muscle actin (α-SMA) in perioperative cells of the four groups from highest to lowest were D, B, C, and A. Nitric oxide concentration inhibited expression of α-SMA in pericytes after SAH at both protein and mRNA levels. The detection results of nitric oxide in the blood of four groups of rats confirmed that pericyte phenotype conversion and actin α-SMA expression could be prevented by upregulation of nitric oxide in serum, so as to relieve pathological symptoms after SAH operation.

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“…The accuracy and reproducibility of the SUV measurement depends on many factors, for example on PET calibration, on reproducibility of clinical protocols, on reconstruction algorithm, on the defined Region of Interest (ROI) or on used analysis methods [27,29]. The physiological SUV mean of liver tissue has been described in the literature with values of 1.88-3.2 and for SUV max up to 5.0 [30][31][32]. The SUV mean of liver metastases of colorectal carcinoma was described with 8.6 (4.1-13.1) [33], the SUV cut-off value for differentiation between normal liver tissue and metastases was described with 3.5 [34].…”

Section: Discussionmentioning

confidence: 99%

“…All patients in patient group A received an 18 F-FDG PET/CT for staging prior to a planned SIRT with exhausted therapy options in accordance with the guidelines. A study performed by Liu et al, 2018 [31] described fluctuations in SUV measurements due to influences of the background metabolism and blood flow of the liver. It is not uncommon for patients with diagnosed liver metastases to have portal vein thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Tumor heterogeneity for differentiation between liver tumors and normal liver tissue in 18F-FDG PET/CT

Hartmann

Bundschuh

Zsótér³

et al. 2020

Nuklearmedizin

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Aim Malignancies show higher spatial heterogeneity than normal tissue. We investigated, if textural parameters from FDG PET describing the heterogeneity function as tool to differentiate between tumor and normal liver tissue. Methods FDG PET/CT scans of 80 patients with liver metastases and 80 patients with results negative upper abdominal organs were analyzed. Metastases and normal liver tissue were analyzed drawing up to three VOIs with a diameter of 25 mm in healthy liver tissue of the tumoral affected and results negative liver, whilst up to 3 metastases per patient were delineated. Within these VOIs 30 different textural parameters were calculated as well as SUV. The parameters were compared in terms of intra-patient and inter-patient variability (2-sided t test). ROC analysis was performed to analyze predictive power and cut-off values. Results 28 textural parameters differentiated healthy and pathological tissue (p < 0.05) with high sensitivity and specificity. SUV showed ability to differentiate but with a lower significance. 15 textural parameters as well as SUV showed a significant variation between healthy tissues out of tumour infested and negative livers. Mean intra- and inter-patient variability of metastases were found comparable or lower for 6 of the textural features than the ones of SUV. They also showed good values of mean intra- and inter-patient variability of VOIs drawn in liver tissue of patients with metastases and of results negative ones. Conclusion Heterogeneity parameters assessed in FDG PET are promising to classify tissue and differentiate malignant lesions usable for more personalized treatment planning, therapy response evaluation and precise delineation of tumors for target volume determination as part of radiation therapy planning.

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Variations of the liver standardized uptake value in relation to background blood metabolism

Cited by 12 publications

References 24 publications

Correlation between semiquantitative and volumetric 18F-FDG PET/computed tomography parameters and Ki-67 expression in breast cancer

Correlation between semiquantitative and volumetric 18F-FDG PET/computed tomography parameters and Ki-67 expression in breast cancer

Analysis of role of rat cerebral pericytes in cerebral vasospasm after subarachnoid hemorrhage and molecular mechanism of neurovascular injury

Tumor heterogeneity for differentiation between liver tumors and normal liver tissue in 18F-FDG PET/CT

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