Variations in <i>TAS1R</i> taste receptor gene family modify food intake and gastric cancer risk in a Korean population

Choi, Jeong-Hwa; Lee, Jeonghee; Choi, Il Ju; Kim, Young Woo; Ryu, Keun Won; Kim, Jeongseon

doi:10.1002/mnfr.201600145

Cited by 19 publications

(12 citation statements)

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“…Furthermore, only small numbers of former/current smoking cases had the combined genotype ( n = 10), and the effects of other confounding factors beyond genetic components may exist (the genotype-tobacco intake association was only predicted by the statistical model after adjusting for confounders). Despite these limitations, this evidence suggests that genetic modulation of bitterness intensity could influence an individual's intake of dietary and consumer goods by interacting with socio-economic characteristics and health behavior and, as a result, may potentially contribute to the risk of CRC [28]. Additional studies are required to establish a clearer role for taste-related genetic variations in the dietary and consumer goods intake of Koreans.…”

Section: Discussionmentioning

confidence: 99%

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

Choi

Lee

et al. 2017

Oncotarget

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Bitterness perception is known to be an important factor in individuals' dietary behaviors and is also associated with the sensing of nutritious/noxious molecules for subsequent metabolic responses in multiple organs. Therefore, the genetic variation in bitterness sensing may be associated with diet-related diseases, including colorectal cancer (CRC). We investigated the influence of variations in the bitterness-sensing genes taste receptor type 2 member 38 (TAS2R38) and carbonic anhydrase 6 (CA6) on the consumption of food, tobacco and alcohol and the risk of CRC in Koreans. The study population consisted of 681 cases and 1361 controls, and their intake of vegetables, fruits, fiber, fat-food and sweets was analyzed. The genotypes for TAS2R38 A49P, V262A and I296V and CA6 rs2274333 A/G were assessed using the MassArray technique. Our findings suggested that the TAS2R38 diplotype, CA6 rs2274333 and their combined genotype had a negligible influence on dietary and alcohol intake. The combined TAS2R38-CA6 AVI/AVI-AA genotype was associated with higher tobacco consumption than the other genotypes in CRC cases only. However, the genetic variations were a significant risk factor for CRC. The TAS2R38 AVI/AVI diplotype and CA6 G allele were associated with a reduced risk of CRC. Moreover, when the combined genotypes of the subjects were analyzed, possessing both the variant diplotype/variant allele (AVI/AVI+G*) was associated with a greater reduction in the risk of CRC (adjusted OR = 0.49; 95%CI: 0.34-0.74). In summary, variations in the bitterness perception genes TAS2R38 and CA6 did not influence the examined food intake in Koreans. However, those genetic variants were a decisive modifying factor of CRC susceptibility.

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Section: Discussionmentioning

confidence: 99%

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

Choi

Lee

et al. 2017

Oncotarget

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“…GI cancer is the leading cause of death worldwide (14). The cause of cancer is multifactorial; therefore, multiple studies have been conducted to understand the mechanisms of cancer development and progression, utilizing various approaches that consider dietary, genetic and environmental factors (6,15,16). Recently, an increasing number of studies have been conducted to examine whether TAS2R38 genetic variation is responsible for GI disorders, especially cancer.…”

Section: Introductionmentioning

confidence: 99%

TAS2R38 Bitterness Receptor Genetic Variation and Risk of Gastrointestinal Neoplasm: A Meta-Analysis

Choi

Kim

2019

Nutrition and Cancer

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Genetic variation in TAS2R38 bitterness taste receptor could alter the efficacy of molecular sensing, hence may be associated with cancer risk. Thus, we performed a meta-analysis to verify the association between the risk of gastrointestinal (GI) neoplasm and TAS2R38 genetic variation. Studies with TAS2R38 diplotype distribution and GI neoplasm phenotypes were searched from PubMed, EMBASE and SCOPUS, and five articles including eight studies were finally selected. The association between diplotype and neoplasm risk was estimated with summarized odds ratios (ORs) and 95% confidence intervals (CIs), applying of fixed-or random-effects models. The findings suggested TAS2R38 diplotype was not associated with GI neoplasms susceptibility [AVI vs.

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“…Our hypothesis finds its rationale on several epidemiologic evidences that polymorphic variants within taste receptor genes could be associated with risk of cancer development. For instance TAS2R38 SNPs were found to be associated with risk of developing CRC in two different populations of Caucasian origin [ 23 ], while SNPs within TAS2R38 and TAS1R s were associated with increased risk of gastric cancer [ 44 , 45 ]. In this study we examined the genetic variability of TAS2R16 gene because the receptor binds different compounds including salicin, a natural anti-inflammatory substance which is very similar to aspirin [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

et al. 2017

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BackgroundGenetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin. Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut.MethodsWe performed an association study using 6 tagging SNPs, (rs860170, rs978739, rs1357949, rs1525489, rs6466849, rs10268496) that cover all TAS2R16 genetic variability. The study was carried out on 1902 CRC cases and 1532 control individuals from four European countries.ResultsWe did not find any statistically significant association between risk of developing CRC and selected SNPs. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (Ptrend of = 0.0071).ConclusionsOur data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts.Electronic supplementary materialThe online version of this article (10.1186/s12876-017-0659-9) contains supplementary material, which is available to authorized users.

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Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population

Abstract: Genetic variants in TAS1R were associated with dietary consumption, which may be associated with GC risk. TAS1R1 rs34160967 may also modify the risk for GC independent of diet in Korean males.

Cited by 19 publications

References 49 publications

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

TAS2R38 Bitterness Receptor Genetic Variation and Risk of Gastrointestinal Neoplasm: A Meta-Analysis

Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

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