Variation in the HIF1A Gene in Elite Rowers

Kalinski, Michael I.; Ostanek, Magdalena; Jascaniene, Nijole; Krupecki, Krzysztof; Ficek, Krzysztof; Sawczuk, Marek; Maciejewska, Agnieszka

doi:10.1519/jsc.0b013e31824b876d

Cited by 6 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the similarity of the Hungarian athletes's genetic background with the Polish population has already been described with other gene variants (Bosnyák et al., 2015). The higher representation of Ser allele (compared to Pro allele frequency and the alleles to the control group) was not discoverable in the power group, so this research cannot strengthen the association of the muscle activity and the Ser allele that was reported before (Ahmetov et al., 2008; Cięszczyk et al., 2011, 2012). It is possible that to demonstrate this connection, it is necessary to analyse the most extreme power performances/athletes, like weightlifters, and the anaerobic energy consumption and short‐distance event are not sensitive enough criteria.…”

Section: Discussionmentioning

confidence: 69%

“…The Ser allele was associated with muscle activity; furthermore, significantly higher proportion of Ser allele was present in Russian weightlifters than in controls (Ahmetov, Hakimullina, Lyubaeva, Vinogradova, & Rogozkin, 2008). Ukrainian and Polish power‐oriented athletes and Polish rowers exhibited an increased frequency of the HIF1A Ser allele as well (Cięszczyk et al., 2011, 2012; Drozdovska et al., 2013). However, the results of Eynon et al.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics

Bosnyák

Trájer

Alszászi

et al. 2020

Annals of Human Genetics

View full text Add to dashboard Cite

The aim was to examine the association between the hypoxia‐inducible factor‐1α (HIF1A) gene and the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene polymorphisms and the endurance/power athlete status and relative aerobic capacity. Another goal of this study was to reveal the connection between GNB3, blood pressure (BP), body composition and body mass index (BMI). Two hundred thirty‐eight people participated in this study: 148 elite athletes (men = 107, women = 41) and 90 controls (men = 51, women = 39). The athletes were divided into two groups: the power and the endurance athletes. BMI and body fat percentage (fat%) were calculated. Fifty of the athletes underwent an incremental treadmill test to exhaustion; BP was monitored before and after the test. There were differences in the genotype frequencies of HIF1A between the endurance and the control group (ProPro: 64% vs.79%, ProSer: 27% vs.19%, SerSer: 9% vs. 2%; p = .0351); in the allele prevalences among the three groups (Pro: 87% vs. 77% vs. 88%; Ser: 13% vs. 23% vs. 12%; p = .0103) and between the endurance and control group (p = .0049) as well. The GNB3 allele proportions differed in the three groups (C: 74% vs. 61% vs. 71%, T: 26% vs. 39% vs. 29%; p = .0436). There were no connections between the genotypes and the relative aerobic capacity and neither between GNB3 genotypes and BP, BMI and fat%. The connection of GNB3 T allele to the endurance performance still remained contradictable.

show abstract

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics

Bosnyák

Trájer

Alszászi

et al. 2020

Annals of Human Genetics

View full text Add to dashboard Cite

show abstract

“…Unfortunately, because of the lack of TT and very low CT genotype frequency in our group, we could not verify these relationships. Furthermore, the discrepancies in results obtained by other researchers (4,7,10,13) confirm that this issue also needs further study.…”

Section: Discussionmentioning

confidence: 83%

HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes

Malczewska-Lenczowska

Orysiak

Majorczyk

et al. 2020

Journal of Strength and Conditioning Research

View full text Add to dashboard Cite

Malczewska-Lenczowska, J, Orysiak, J, Majorczyk, E, Sitkowski, D, Starczewski, M, and Żmijewski, P. HIF-1α and NFIA-AS2 polymorphisms as potential determinants of total hemoglobin mass in endurance athletes. J Strength Cond Res 36(6): 1596–1604, 2022—The aims of this study were to examine (1) the genotype distribution of rs11549465:C>T of the HIF-1α gene and rs1572312:C>A of the NFIA-AS2 gene; (2) the association between the genes and hematological status in endurance-oriented athletes; and (3) the association between the NFIA-AS2 gene and aerobic capacity in cyclists. Two hundred thirty-eight well-trained athletes (female n = 90, male n = 148) participated in the study. Total hemoglobin mass (tHbmass), blood morphology, intravascular volumes, i.e., erythrocyte volume (EV), blood volume (BV) and plasma volume (PV), and aerobic capacity indices, e.g., peak oxygen uptake (V̇o2peak), and power at anaerobic threshold (PAT) were determined. In both studied genes, the CC genotype was predominant. In the HIF-1α gene, there were no differences in genotype and allele distribution among athletes from different disciplines and between sexes. The distribution of genotypes and alleles of the NFIA-AS2 gene differed significantly in male athletes; the frequency of A allele carriers (CA + AA) was significantly higher in cyclists than in rowers and middle- and long-distance runners. The athletes with CC genotype of NF1A-AS2 had significantly higher relative values of: tHbmass (total female athletes, cyclists), PV, BV (cyclists), and EV (total male athletes, cyclists) and PAT (cyclists) than A allele carriers (CA + AA genotypes). In conclusion, our study indicates that NFIA-AS2 rs1572312:C>A polymorphism was associated with hematological status in endurance athletes, as well as aerobic capacity indices in male cyclists. It suggests that this polymorphism may be a determinant of quantity of hemoglobin and intrtavascular volumes, which in turn can have an impact on aerobic performance.

show abstract

“…From 5 studies investigating the distribution frequencies of HIF1A gene polymorphism in endurance athletes, 695 athletes and 968 controls were analyzed (Bosnyák et al 2020 ; Cieszczyk et al 2012 ; Döring et al 2010 ; Drozdovska et al 2013 ; Eynon et al 2010 ). Regarding the HIF1A (rs11549465) SNP, significant differences were detected only in the rowers subgroup, with the major allele (Pro) [OR: − 0.45 [− 0.78; − 0.13]] and in the dominant model [OR: − 0.47 [− 0.83; − 0.12]] ( p < 0.05) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status

İpekoğlu,

Apaydın,

Çetin

et al. 2024

Eur J Appl Physiol

View full text Add to dashboard Cite

Purpose Genetic factors are important in terms of athletic performance. Recent studies to determine the relationship between the genes that lead to physiological responses have attracted attention. In this respect, this meta-analysis study was designed to examine the relationship between genetic polymorphism (BDKRB2 rs5810761, GNB3 rs5443, HIF1A rs11549565, MCT1 rs1049434, NOS3 rs2070744) and endurance athlete’s status. Methods The search included studies published from 2009 to 2022. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned. Only case-control studies were included in the meta-analysis. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned, and a total of 31 studies met the criteria for inclusion in the meta-analysis. Relevant data from the included studies were collected and analyzed using a random effects or fixed effects model. The effect size was calculated as the odds ratio or a risk ratio the corresponding 95% confidence intervals. Results According to the results of the analysis, BDKRB2 rs5810761 + 9 allele, and NOS3 rs2070744 T allele were significantly more prevalent in endurance athletes (p < 0.05). Genotype distributions of BDKRB2 rs5810761, MCT1 rs1049434, and NOS3 rs2070744 showed significant differences in the dominant model (p < 0.05). However, no significant association was found between endurance athlete status and GNB3 rs5443 and HIF1A rs11549465 polymorphisms. Conclusion These results show that some gene polymorphisms play an important role in endurance athlete status and suggest that having a specific genetic basis may also confer a physiological advantage for performance.

show abstract

Variation in the HIF1A Gene in Elite Rowers

Cited by 6 publications

References 24 publications

Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics

Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics

HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status

Contact Info

Product

Resources

About