Variation in half-life of penta-chlorodibenzofuran (PeCDF) blood level among Yusho patients

Matsumoto, Shimpei; Akahane, Manabu; Kanagawa, Yoshiyuki; Koike, Soichi; Yoshimura, Takesumi; Mitoma, Chikage; Shibata, Satoko; Uchi, Hiroshi; Furue, Masutaka; Imamura, Tomoaki

doi:10.1016/j.chemosphere.2009.08.009

Cited by 17 publications

(15 citation statements)

References 12 publications

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“…Many researchers have reported half-lives of PCBs to be less than 10 to 15 years [9, 10]. Among patients with blood concentrations of 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) ≥50 pg/g lipid, we identified two groups: one showing an apparent half-life of ≈ 10 years and the other showing no reduction in 2,3,4,7,8-PeCDF levels over time [11]. This suggests that the latter group of patients maintained high blood levels of 2,3,4,7,8-PeCDF.…”

Section: Introductionmentioning

confidence: 99%

Change in decay rates of dioxin-like compounds in Yusho patients

et al. 2016

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BackgroundOnce ingested, dioxins and dioxin-like compounds are excreted extremely slowly. Excretion can be evaluated by its half-life. Half-lives estimated from observed concentrations are affected by excretion and ongoing exposure. We investigated the change in apparent half-life using a theoretical model based on exposure to dioxin and dioxin-like compounds.MethodsWe carried out longitudinal measurements of the blood concentration of dioxins and dioxin-like compounds in a Yusho cohort during 2002 to 2010. We estimated the change in decay rates of 2,3,4,7,8-PeCDF and octachlorodibenzodioxin (OCDD) using a second-order equation.ResultsWe found that the decay rate of OCDD increased, whereas the decay rate of 2,3,4,7,8-PeCDF of patients with a relatively high concentration of 2,3,4,7,8-PeCDF decreased. OCDD results were in accordance with decreasing levels of dioxin and dioxin-like compounds in the environment. The decay rate of OCDD in the body was affected by the decay rate of OCDD in the environment by ingestion because it was near the steady-state. In contrast, the decay rate of 2,3,4,7,8-PeCDF in the body was affected less by ingestion from the environment because it was far higher than in the steady-state.ConclusionWe demonstrated that the level of 2,3,4,7,8-PeCDF in the environment is decreasing. The excretion half-life is longer than the environmental half-life, thus the excretion half-life in a Yusho patient is increased.

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Section: Introductionmentioning

confidence: 99%

Change in decay rates of dioxin-like compounds in Yusho patients

et al. 2016

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“…The strong influence of ongoing exposure and loss of body weight on half-life estimates from incident cohorts that were measured decades after the exposure incident is demonstrated by the observation of very long and even negative apparent half-lives reported for pentachlorodibenzofuran in Yusho patients (Matsumoto et al 2009). Increasing concentrations (i.e., negative half-lives) can be explained only by additional intake or significant weight reductions under the condition that the substance is not a metabolite synthesized within the body.…”

Section: Discussionmentioning

confidence: 99%

“…Apparent half-lives that have been reported for persistent chemicals such as PCBs and polychlorinated dibenzodioxins and dibenzofurans are therefore highly variable. Values for individual substances range from < 1 year to several decades, and even negative values have been reported (Matsumoto et al 2009; Milbrath et al 2009; Shirai and Kissel 1996). We use the term “intrinsic” half-life, rather than “true” half-life (Shirai and Kissel 1996), to unequivocally specify half-lives estimated with methods that account for, and thereby eliminate the influence of, the effects of ongoing exposure and changes in body weight.…”

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Intrinsic Human Elimination Half-Lives of Polychlorinated Biphenyls Derived from the Temporal Evolution of Cross-Sectional Biomonitoring Data from the United Kingdom

Ritter

Scheringer

MacLeod

et al. 2011

Environ Health Perspect

208

151

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BackgroundMost empirical estimates of human elimination kinetics for persistent chemicals reflect apparent elimination half-lives that represent the aggregated effect of intrinsic elimination, ongoing exposure, and changes in body weight. However, estimates of intrinsic elimination at background levels are required for risk assessments for the general population.ObjectiveTo estimate intrinsic human elimination half-lives at background levels for nine polychlorinated biphenyl (PCB) congeners, we used a novel approach based on population data.MethodsWe used a population pharmacokinetic model to interpret two sets of congener-specific cross-sectional age–concentration biomonitoring data of PCB concentrations measured in lipid and blood samples that were collected from 229 individuals in 1990 and 2003. Our method is novel because it exploits information about changes in concentration in the human population along two dimensions: age and calendar time.ResultsOur approach extracted information about both elimination kinetics and exposure trends from biomonitoring data. The longest intrinsic human elimination half-lives estimated in this study are 15.5 years for PCB‐170, 14.4 years for PCB‐153, and 11.5 years for PCB‐180.ConclusionsOur results are further evidence that a maximum intrinsic elimination half-life for persistent chemicals such as PCBs exists and is approximately 10–15 years. A clear conceptual distinction between apparent and intrinsic half-lives is required to reduce the uncertainty in elimination half-lives of persistent chemicals. The method presented here estimates intrinsic elimination half-lives and the exposure trends of persistent pollutants using cross-sectional data available from a large and growing number of biomonitoring programs.

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“…A survey of Seveso (Kerger et al, 2006) demonstrated that the half-lives of dioxins are dependent upon a patient's age and dioxin concentrations. In addition, a recent study of the variation in the half-life of 2,3,4,7,8-PeCDF in the blood of Yusho patients (Matsumoto et al, 2009) showed that there is a group of patients whose dioxins have remained at higher concentrations than previously predicted.…”

Section: Introductionmentioning

confidence: 96%