Variation in functional connectivity along anterior-to-posterior intraparietal sulcus, and relationship with age across late childhood and adolescence

Abstract

The intraparietal sulcus (IPS), a region in the dorsal attention network (DAN), has been implicated in multi-sensory attention and working memory. Working memory and attention develop across childhood; changes in functional connectivity within the DAN may relate to this maturation. Previous findings regarding fronto-parietal intrinsic functional connectivity age-effects were mixed. Our study aimed to circumvent limitations of previous work using a large cross-sectional sample, 183 typically developing participants 6.5-20 years, from the Autism Brain Imaging Data Exchange, and seed regions along the anterior-to-posterior axis of the IPS. These seeds, IPS0-4, were entered into functional connectivity models. Group-level models investigated differential connectivity along the IPS and relationships with age. Anterior IPS3/4 exhibited greater connectivity with sensorimotor/pre-motor regions. Posterior IPS0/1 demonstrated greater connectivity with dorsal and ventral visual regions. Positive age-effects were found between IPS3-4 and visual regions. Negative age-effects were found between IPS and superior parietal and medial orbitofrontal cortices. Follow-up region of interest analyses were used to estimate age-effects for DAN and anticorrelated default mode network regions. Results suggest age-effects on IPS functional connectivity are relatively modest, and may differ pre- and across-adolescence. Studying typical age-related connectivity variability within this network may help to understand neurodevelopmental disorders marked by impaired attention.

Age-Related Decline in the Variation of Dynamic Functional Connectivity: A Resting State Analysis

“…The inter-network between FPN and OCC was also indicated to be missing in the senior group (Figures 1B,E ). These findings might indicate a posterior-anterior shift in aging (Davis et al, 2008 ; Vinette and Bray, 2015 ), which has been interpreted as compensatory in that higher-order cognitive processes are recruited to offset deficits in sensory processing. In all of the 3D views of changed connections, many posterior-anterior connections were also obvious.…”

The Transitions Between Dynamic Micro-States Reveal Age-Related Functional Network Reorganization

“…In fact, with age increasing, brain functional connectivity or networks also show dynamic changes (Park and McDonough, 2013). For example, in aging individuals, the primary perceptual system declines, and higher-order cognitive systems are recruited to offset deficits in sensory processing (Davis et al, 2008; Vinette and Bray, 2015); the decay in the default mode network can lead to decreased anticorrelations and increased regulation from the frontoparietal control system (Grady et al, 2016; Spreng et al, 2016). These results indicates that frequent changes in internetwork interactions and some connectivity transition patterns are associated with aging.…”

Deficit Of Executive Cognitive Functioning In Adolescents Showing Signs Of Deviant Behavior

“…Despite intensive studies of individual traits of behavior and cognitive development during adolescence (Casey, 2015, review) the question of why this developmental period is accompanied by increased risk of deviant behavior remains open. A scientific analysis of this phenomenon faces an apparent contradiction between progressive age-related changes in executive functions and underlying brain mechanisms of the latter (Klingberg, Forssberg & Westerberg, 2002;Blakemore & Choudhury, 2006;Karn, Isbell, Giuliano & Neville, 2015;Vinette & Bray, 2015), on the one hand, and a reduced ability for selfcontrol, on the other hand (Cauffman, Steinberg & Piquero, 2005;Spear, 2000;Steinberg, 2010).…”