Variance of common flavonoids by brand of grapefruit juice

Citrus Juices Inhibit the Function of Human Organic Anion-Transporting Polypeptide Oatp-B

“…In this study, these constituents were demonstrated to inhibit the function of OATP-B. GFJ contains very high levels of naringin (up to 1000 M) in comparison with other constituents (Ross et al, 2000). However, the content of each constituent depends upon the brand, origin, picking season, and other factors, and we did not quantify the content of these constituents in this study.…”

“…Contributions of these transporters cannot be excluded. GFJ contains high levels of bioflavonoids, including naringin, its aglycone naringenin, and quercetin (Bailey et al, 2000;Ross et al, 2000). Furanocoumarins, such as bergamottin and 6Ј,7Ј-dihydroxybergamottin, are also contained in GFJ and are considered to be major constituents responsible for inhibition of CYP3A4 (Guo et al, 2000).…”

Bioactive compounds and antioxidant capacities in the flavedo tissue of two citrus cultivars under low temperature

“…Citrus fruit extracts have health benefits that mainly is attributed to the presence of bioactive compounds, such as vitamin C (Knekt et al, 2004), phenolics (e.g. flavanone glycosides, hydroxycinnamic acids) (Rossa et al, 2000), and carotenoids (Craig, 1997) are also found to have activities, such as anti-inflammatory, anti-tumor, anti-fungal and blood clot inhibition activities (Olson, 1988;Middleton and Kandaswami, 1994;Yehoshua et al, 1995). So far, studies mainly focused on bioactive compounds and total antioxidant capacities (TAC) of citrus (Gorinstein et al, 2004a;Yoo et al, 2004) and juice (Gardner et al, 2000;Gorinstein et al, 2004b).…”

The potential use of flavonoids as venoactive drugs and the role of citrus fruits

“…Should the useful properties of Fl be confirmed, the question will arise whether pharmaceuticals could be replaced by enhanced consumption of citrus fruits known to be among the most common phenolic-rich dietary sources [4]. Taking into account the maximum concentration of total Fl in grapefruit juice (up to 84.28 mg/100 ml) [36], the average for commercial grapefruit juice (65 mg/100 ml) [4] and the higher content of Fl in whole fruits than in juice [21,37], consumption of 1-2 grapefruits means the intake of about 500 mg of Fls (naringin, narirutin, hesperidin, etc.) Naringin and naringenin are bitter and occur predominantly in grapefruits [4,5].…”