Variable seasonal peaks for different types of aortic dissection?

Abstract

Seasonal differences in the manifestation of cardiac death caused by arrhythmia, heart failure or acute myocardial infarction, with peaks during winter months, have been reported.1 Circadian patterns have also been shown for aortic dissection.2 A recent large population based study failed to find convincing statistical evidence of seasonal variability for ruptured aneurysms and dissections of the abdominal aorta. 3 An analysis of 85 patients with non-traumatic rupture of the thoracic aorta found a higher occurrence during winter.4 However, there is little additional evidence from the literature that acute dissection of the thoracic aorta would be subject to cyclic variations throughout the year, although daily clinical practice suggests such seasonal variability in the occurrence of aortic dissection. Moreover, it is not known whether all types of aortic dissection follow the same pattern of incidence. Therefore, we reviewed all records of patients admitted to our hospital for acute dissection from autumn 1990 to summer 2001. METHODSThe screening and confirmation of the diagnosis of acute aortic dissection was performed exclusively by transoesophageal echocardiography, so that every patient with dissection could be included in the present analysis. Hence, within the 11 year period of the study, acute aortic dissection was diagnosed in 389 patients (294 men, 95 women). In 282 patients (208 men, 74 women) acute Stanford type A aortic dissection was found, while 107 patients (86 men, 21 women) had Stanford type B aortic dissection. Over the study period the annual number of Stanford type A and type B dissections remained stable (p = 0.26 and p = 0.23, respectively; χ 2 test). Cyclic variation regarding the incidence of the different types of acute aortic dissection throughout the year was analysed by dividing the year into its four seasons of equal length. Each season was compared with the rest of the year using χ 2 test with Bonferroni correction (significance for p values < 0.0125). RESULTSFor Stanford type A aortic dissection a significant peak of 89 cases in winter versus 65 in spring, 68 in summer, and 60 in autumn was found (p = 0.011) (fig 1). Conversely, for Stanford type B aortic dissection, there was a peak incidence in spring with 40 cases versus 28 in summer, 22 in autumn, and 17 in winter (p = 0.003) (fig 1).To elucidate the climatic conditions in Zurich we analysed the mean temperature prevailing at the four respective seasons during the 11 year study period: in spring the mean temperature was 11.6°C, in summer 17.2°C, in autumn 6.4°C, and in winter 2.4°C. DISCUSSIONThe underlying factors for the observed seasonal differences regarding both Stanford type A and type B dissections are not well understood, but the pattern of Stanford type A dissection resembles that of cyclic arterial blood pressure variation, which exhibits a seasonal peak in the coldest season.5 Higher blood pressure levels in winter nicely parallel our observation of a higher incidence of Stanford type A aortic dissection during winte...

Seasonal incidence of hospital admissions for Stanford type A aortic dissection

“…Studies to date that have examined the association between season and incidence of SA-AoD have yielded mixed results. A statistically significant seasonal variation with a peak in winter was observed by two European case series (France, n ¼ 206, p ¼ 0.018; Switzerland, n ¼ 282, p ¼ 0.011) (Benouaich et al, 2010;Kobza et al, 2002). In contrast, a seasonal variation in incidence was not observed among 570 patients with SA-AoD enrolled in the International Registry of Acute Aortic Dissection (IRAD) between 1996 and 2000 (p ¼ 0.31) (Mehta et al, 2002).…”

“…Other studies of aortic dissection and season have reported statistical results as a pooled group, often because of small numbers or convenience (Lasica et al, 2006;Manfredini et al, 2008;Matsuo, 1998;Sumiyoshi et al, 2002;Upshur et al, 2000). However, these studies are difficult to interpret since it is not wellestablished whether all types of aortic dissection follow a similar seasonal distribution (Kobza et al, 2002;Mehta et al, 2002).…”

Chronobiology in Aortic Diseases – “Is This Really a Random Phenomenon?”

“…According to a series of studies, fall and winter months represent a high-risk temporal frame for occurrence of aortic rupture or dissection, [56][57][58][59][60][61][62][63][64][65][66][67][68][69] although there is also evidence of no seasonality 70,71 (Table 2).…”

Current status of the management and outcomes of acute aortic dissection in Japan: Analyses of nationwide Japanese Registry of All Cardiac and Vascular Diseases-Diagnostic Procedure Combination data

“…The median length of hospitalization (survival to discharge) was significantly longer in type A than in type B (type A: 28 (20-40) vs type B: 22 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) days; p<0.001) ( Table 1). Compared with open surgery, the hospitalization duration was shorter in patients who underwent TEVAR for type B (TEVAR: 22 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) vs open surgery: 42 (30-62) days) ( Table 3); however, no marked difference was found in those with type A (TEVAR: 31 vs open surgery: 28 (20-41) days). The medical costs of the patients who were discharged alive were more than five times higher in type A patients than that in type B patients (type A: 6.26 vs type B: 1.18 million Japanese yen) ( Table 1).…”