Variability of chronic antidepressant treatments on beta-adrenergic receptor sites

Antidepressant Treatments, Including Sibutramine Hydrochloride and Electroconvulsive Shock, Decrease β1 but Not β2‐Adrenoceptors in Rat Cortex

“…This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl. Both previous studies reported that some decrease in number of cortical P-adrenoceptors did occur after repeated zimeldine treatment, and, in particular, Suranyi-Cadotte et al (1985) found a 33% reduction in number of P-adrenoceptors, which was not statistically significant because of the small sizes of the experimental groups. The MA0 inhibitor tranylcypromine also downregulated P-adrenoceptors after prolonged administration, and this agrees with the findings of Sellinger- Barnette et al (1980) and Frazer (198 1).…”

“…Amitnptyline and sibutramine HC1 are nonselective inhibitors of noradrenaline and 5-HT reuptake, and both compounds have previously been shown to decrease the number of cortical P-adrenoceptors (Sellinger-Barnette et al, 1980;Sugrue, 1983;Buckett et al, 1988). However, in the case of zimeldine, although previous investigators have found a decrease in the activity of @-adrenoceptor-linked adenylate cyclase, no reduction in receptor number has been observed (Sulser and Mobley, 1981;Suranyi-Cadotte et al, 1985). This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl.…”

Antidepressant Treatments, Including Sibutramine Hydrochloride and Electroconvulsive Shock, Decrease β1 but Not β2‐Adrenoceptors in Rat Cortex

“…This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl. Both previous studies reported that some decrease in number of cortical P-adrenoceptors did occur after repeated zimeldine treatment, and, in particular, Suranyi-Cadotte et al (1985) found a 33% reduction in number of P-adrenoceptors, which was not statistically significant because of the small sizes of the experimental groups. The MA0 inhibitor tranylcypromine also downregulated P-adrenoceptors after prolonged administration, and this agrees with the findings of Sellinger- Barnette et al (1980) and Frazer (198 1).…”

“…Amitnptyline and sibutramine HC1 are nonselective inhibitors of noradrenaline and 5-HT reuptake, and both compounds have previously been shown to decrease the number of cortical P-adrenoceptors (Sellinger-Barnette et al, 1980;Sugrue, 1983;Buckett et al, 1988). However, in the case of zimeldine, although previous investigators have found a decrease in the activity of @-adrenoceptor-linked adenylate cyclase, no reduction in receptor number has been observed (Sulser and Mobley, 1981;Suranyi-Cadotte et al, 1985). This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl.…”

Antidepressant Treatments, Including Sibutramine Hydrochloride and Electroconvulsive Shock, Decrease β1 but Not β2‐Adrenoceptors in Rat Cortex

“…This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl. Both previous studies reported that some decrease in number of cortical P-adrenoceptors did occur after repeated zimeldine treatment, and, in particular, Suranyi-Cadotte et al (1985) found a 33% reduction in number of P-adrenoceptors, which was not statistically significant because of the small sizes of the experimental groups. The MA0 inhibitor tranylcypromine also downregulated P-adrenoceptors after prolonged administration, and this agrees with the findings of Sellinger- Barnette et al (1980) and Frazer (198 1).…”

“…Amitnptyline and sibutramine HC1 are nonselective inhibitors of noradrenaline and 5-HT reuptake, and both compounds have previously been shown to decrease the number of cortical P-adrenoceptors (Sellinger-Barnette et al, 1980;Sugrue, 1983;Buckett et al, 1988). However, in the case of zimeldine, although previous investigators have found a decrease in the activity of @-adrenoceptor-linked adenylate cyclase, no reduction in receptor number has been observed (Sulser and Mobley, 1981;Suranyi-Cadotte et al, 1985). This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl.…”

Antidepressant Treatments, Including Sibutramine Hydrochloride and Electroconvulsive Shock, Decrease β1 but Not β2‐Adrenoceptors in Rat Cortex

“…This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl. Both previous studies reported that some decrease in number of cortical P-adrenoceptors did occur after repeated zimeldine treatment, and, in particular, Suranyi-Cadotte et al (1985) found a 33% reduction in number of P-adrenoceptors, which was not statistically significant because of the small sizes of the experimental groups. The MA0 inhibitor tranylcypromine also downregulated P-adrenoceptors after prolonged administration, and this agrees with the findings of Sellinger- Barnette et al (1980) and Frazer (198 1).…”

“…Amitnptyline and sibutramine HC1 are nonselective inhibitors of noradrenaline and 5-HT reuptake, and both compounds have previously been shown to decrease the number of cortical P-adrenoceptors (Sellinger-Barnette et al, 1980;Sugrue, 1983;Buckett et al, 1988). However, in the case of zimeldine, although previous investigators have found a decrease in the activity of @-adrenoceptor-linked adenylate cyclase, no reduction in receptor number has been observed (Sulser and Mobley, 1981;Suranyi-Cadotte et al, 1985). This is perhaps surprising, because although zimeldine is a very selective 5-HT reuptake inhibitor, its major metabolite norzimeldine does not retain this selectivity (Ross and Renyi, 1977), and the latter compound has a reuptake inhibition profile similar to that of amitriptyiine and sibutramine HCl.…”